Fig. 6
From: Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1
Schematic representation of AMF secretion and interaction with GPER-1, which drive EC progression. AMF is secreted through a non-classical mechanism and interacts with GPER-1, which results in GPER-1 activation and translocation. AMF binding with GPER-1 activates the PI3K signaling pathway, which enhances cell growth and suppresses cell apoptosis. The interaction between AMF and GPER-1 may contribute to tumor malignancy and provide targeted therapy for the treatment of EC