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Goodpasture’s syndrome

Goodpasture’s syndrome

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    * Goodpasture’s syndrome is an autoimmune disorder caused by antibodies that attack the basement membranes of renal glomeruli and/or respiratory alveoli; specifically, the antibodies attack type IV collagen in the tissues.
— In a histological sample of an affected glomerulus, we can see the characteristic crescent-shaped area formed by excessive fibrin and cellular material. — In a sample of lung tissue, we highlight hemorrhaging in the inflamed alveoli. — Goodpasture’s syndrome may be treated with corticosteroids and cyclophosphamide, or plasmapheresis, which removes the attacking antibodies.

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