Cholinesterase Test To Check Signs of Chemical Poisoning in the Blood

Cholinesterase Test To Check Signs of Chemical Poisoning in the Blood

The Cholinesterase Test checks enzyme activity for nerve health and toxin exposure. It's crucial in industries to ensure worker safety and overall well-being. Learn how it safeguards against potential health risks.

 

Cholinesterase Test

Here are the basic details of the Cholinesterase Test.

Also Known As Cholinesterase Activity Test
Type Blood Test
Purpose Assess nerve health & toxin exposure
Sample Type Serum
Preparation No
Fasting No required
Gender Unisex
Age Group All
Normal Value 8-18 (U/mL)
Reporting Time A few days
Cost 450-900 INR*

*Price range may vary as per location, lab type, and procedure of lab test.

 

Cholinesterase Test Means

A Cholinesterase Test measures the activity of cholinesterase enzymes to evaluate nerve health and detect exposure to toxins, especially in occupational settings.

  • It helps identify organophosphate pesticide poisoning and assess susceptibility to succinylcholine sensitivity.
  • The test involves blood sample collection and can be vital for monitoring those at risk in industries like agriculture and chemical manufacturing.
  • Cholinesterase Test results can vary based on individual enzyme levels and potential exposures.
  • It aids in safeguarding worker well-being and guiding medical decisions in cases of prolonged muscle paralysis following anesthesia.

 

Cholinesterase Test Purpose

The purpose of the Cholinesterase Test is to:

  • Assesses enzyme activity for nerve health and toxin exposure.
  • Helps detect organophosphate pesticide poisoning and other toxic exposures.
  • Identifies susceptibility to succinylcholine sensitivity in anesthesia.
  • Monitors worker safety in industries with chemical and pesticide exposure.
  • Guides medical decisions for individuals at risk of muscle paralysis.

Cholinesterase Test_ Price, Normal Range, Result, Purpose, Meaning and Interpretation - Drlogy Test

 

Cholinesterase Test Preparation

Here is the basic preparation for the Cholinesterase Test.

 

Before Test

  • No specific fasting or dietary restrictions are typically required.
  • Inform the healthcare provider about any medications or supplements you're taking.
  • Be prepared for a simple blood sample collection.

 

During Test

  • The test involves drawing a blood sample from a vein.
  • It's a relatively quick and straightforward procedure.
  • You may experience mild discomfort during the blood draw.

 

After Test

  • Resume your regular activities immediately.
  • Some individuals might experience minor bruising at the puncture site.
  • Wait for the lab to report your results, typically within a few days.

 

Cholinesterase Test Procedure

Here is the basic Cholinesterase Test Procedure.

  • Blood sample is collected from a vein.
  • The collected sample is sent to a laboratory for analysis.
  • Cholinesterase enzyme activity levels are measured in the sample.
  • Results are typically reported within a few days.
  • Healthcare professionals interpret results to assess nerve health and toxin exposure.

 

Cholinesterase Test Result

  • Cholinesterase test results indicate enzyme activity levels in the blood.
  • Lower activity may suggest toxin exposure or succinylcholine sensitivity risk.
  • Healthcare providers interpret results within the context of an individual's health and potential exposures.

 

Cholinesterase Test Normal Range

Here is the normal range of the Cholinesterase Test.

Measurement Normal Range
Pseudocholinesterase 8-18 U/mL or 8-18 kU/L

 

Cholinesterase Test Interpretation

Here is the Interpretation of the Cholinesterase Test.

Result Interpretation
< 35% of normal Suggestive of severe poisoning
35-50% of normal Indicative of mild to moderate poisoning
50-100% of normal Within the expected range (normal or no poisoning)
Above 100% of normal Higher than normal, but not related to poisoning

Cholinesterase Test assesses enzyme activity, with a normal range of 8-18 U/mL or 8-18 kU/L; a drop of >35% suggests severe poisoning.

 

Cholinesterase Test High Levels

Here are some possible causes of high Cholinesterase levels:

Possible Causes Description
Liver Disease Impaired metabolism due to liver dysfunction
Pregnancy Normal physiological increase during pregnancy
Some Medications Certain drugs can temporarily elevate levels

High Cholinesterase levels can result from liver disease, pregnancy, or specific medications.

 

Cholinesterase Test Low Levels

Here are some possible causes of low Cholinesterase levels:

Possible Causes Description
Organophosphate Poisoning Exposure to toxic chemicals like pesticides
Succinylcholine Sensitivity Inherited enzyme deficiency affecting drug metabolism
Chronic Liver Disease Liver dysfunction leading to enzyme reduction
Malnutrition Inadequate nutrition can lower enzyme levels
Renal Disease Kidney problems may impact enzyme activity

Cholinesterase Test assesses enzyme levels; low levels may signal poisoning or medical conditions like liver disease.

 

Specimen Requirements For Cholinesterase Test

Here are the specimen requirements for the Cholinesterase Test.

Specimen

Serum

Volume

0.5 mL

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells immediately after clotting (30 minutes) and place in transport tube. Mark transport tube “serum”.

Storage

Room temperature

Sample Stability

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Causes for Rejection

Whole blood specimen (a 20% to 25% increase can occur over a 24-hour period if serum is left on the clot); hemolysis

 

Cholinesterase Test is Safe?

Cholinesterase Test is generally safe.

  • It involves a routine blood sample.
  • Minimal discomfort during blood draw may occur.
  • No significant risks associated with the test.
  • Performed by trained healthcare professionals.

 

When Do You Get Cholinesterase Test Results? 

  • Cholinesterase Test results typically available in a few days.
  • Actual turnaround time may vary depending on the laboratory.
  • Healthcare provider or lab will provide the specific timeline.

 

Cholinesterase Test Limitation

Here is the basic limitation of Cholinesterase Test.

  • Results influenced by individual variations.
  • Affected by factors like age, gender, and medications.
  • Doesn't identify the specific toxin.
  • May not distinguish between different types of cholinesterases.
  • Interpretation requires clinical context.

 

Cholinesterase Test Risk Factors

Here are some of the risk factors of the Cholinesterase Test.

  • Occupational exposure to pesticides and chemicals.
  • Occupational settings in agriculture and chemical industries.
  • Personal or family history of succinylcholine sensitivity.
  • Prolonged muscle paralysis after anesthesia.
  • Prior exposure to organophosphate compounds.

 

Doctor Recommendations After Cholinesterase Test Result

 Here are the Doctor's recommendations or consult a specialist after the Cholinesterase Test.

Cholinesterase Result Doctor to Consult Reason
High Primary Care Physician or Specialist Determine underlying cause.
Normal No specific visit required -
Low Primary Care Physician or Specialist Assess potential toxin exposure.

 

Cholinesterase Test Price

Here are the estimated Cholinesterase Test Prices in India with different top cities:

City

Price Range (INR)*

Mumbai

400-900

New Delhi

450-900

Bangalore

400-900

Hyderabad

450-900

Kolkata

400-900

Pune

450-900

Lucknow

400-900

Noida

450-900

Surat

450-900

Gurugram

400-900

Patna

450-900

Chennai

400-900

Jaipur

450-900

Ahmedabad

400-900

*Prices are approximate and vary depending on a specific laboratory or healthcare facility.

 

Summary

Overall, The Cholinesterase Test evaluates nerve health and toxin exposure, aiding in the detection of pesticide poisoning and anesthesia sensitivity. Also check Drlogy Test for detailed information about all medical tests for patients, doctors, scholers and medical students.

 

Reference

  • Cholinesterase - Wikipedia [1].
  • Cholinesterase - blood - UCSF [2].
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Cholinesterase Test FAQ

What is a Cholinesterase Test?

A Cholinesterase Test is a medical examination that measures the activity of cholinesterase enzymes in the blood. These enzymes play a crucial role in nerve function and muscle control.

How long does it take to get Cholinesterase Test results?

Typically, results are available within a few days, but the exact timeframe may vary depending on the laboratory's workload and testing methods.

How much does a Cholinesterase Test cost?

The cost of a Cholinesterase Test typically ranges from INR 700 to INR 1000 in India. However, it's important to note that the exact cost may vary depending on the location of the healthcare facility, any additional services or consultations included, and whether you have health insurance coverage. It's advisable to check with the specific laboratory or healthcare provider for the most accurate pricing information for the test.

How do I prepare for a Cholinesterase Test?

There is usually no specific preparation required. However, it's essential to follow any instructions provided by your healthcare provider or the testing facility for accurate results.

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