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Details

Stereochemistry ACHIRAL
Molecular Formula C10H7Cl2NO
Molecular Weight 228.075
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CHLORQUINALDOL

SMILES

CC1=NC2=C(C=C1)C(Cl)=CC(Cl)=C2O

InChI

InChIKey=GPTXWRGISTZRIO-UHFFFAOYSA-N
InChI=1S/C10H7Cl2NO/c1-5-2-3-6-7(11)4-8(12)10(14)9(6)13-5/h2-4,14H,1H3

HIDE SMILES / InChI

Molecular Formula C10H7Cl2NO
Molecular Weight 228.075
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description is created based on several sources, including http://www.sciencedirect.com/science/article/pii/S0022202X15488141 and http://www.ncbi.nlm.nih.gov/pubmed/140848

Chlorquinaldol is a halogenated hydroxyquinoline with properties similar to those of clioquinol. It is mainly applied topically in infected skin conditions and in vaginal infections. The product is applied for local treatment of cortico-sensitive dermatosis with moderately manifested superinfection, acute and subacute eczema, dermatitis, pyodermia, intertrigo, infected wounds, dermatomycosis, pemphigus in newborn. Chlorquinaldol is also used as antiseptic, fungistat, or deodorant. Chlorquinaldol is not commercially available in the U.S. but is used in other countries principally as an amebicide for nonspecific diarrheas and gynecologic infections. It is known most commonly under the proprietary name of Sterosan. Other trade names include Cynotherax, Gyno-Sterosan, Saprosan, Siogeno, Siosteran, Slosteran and Steroxin.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Escherichia coli growth
10.1 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Chlorquinaldol

Approved Use

Chlorquinaldol is primarily indicated in conditions like skin infections, vaginal infections.

Launch Date

1.18756803E12
Curative
Gynosan Vaginal Pessary

Approved Use

Gynosan Vaginal Pessary is used in the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms: skin infections, vaginal infections
PubMed

PubMed

TitleDatePubMed
Cutaneous drug reaction case reports: from the world literature.
2002
[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].
2004 May
Patents

Sample Use Guides

Applied in a thin layer on affected skin areas 1-3 times daily. Therapy duration is up to 8 days.
Route of Administration: Topical
In Vitro Use Guide
Chlorquinaldol displayed enhanced E. coli 205 bactericidal activity in human duodeno-pancreatic secretions with MIC 0.5ug/ml
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:02:24 UTC 2023
Edited
by admin
on Fri Dec 15 15:02:24 UTC 2023
Record UNII
D6VHC87LLS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CHLORQUINALDOL
INN   MART.   MI   WHO-DD  
INN  
Official Name English
CHLORQUINALDOL [MART.]
Common Name English
CHLORQUINALDOL [MI]
Common Name English
Chlorquinaldol [WHO-DD]
Common Name English
5,7-DICHLORO-2-METHYL-8-QUINOLINOL
Systematic Name English
chlorquinaldol [INN]
Common Name English
NSC-755830
Code English
Classification Tree Code System Code
WHO-ATC D08AH02
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
WHO-ATC P01AA04
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
WHO-VATC QG01AC03
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
NCI_THESAURUS C28394
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
NDF-RT N0000185508
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
WHO-ATC G01AC03
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
WHO-ATC R02AA11
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
WHO-VATC QR02AA11
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
WHO-VATC QD08AH02
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
Code System Code Type Description
NSC
755830
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
RXCUI
2407
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY RxNorm
NCI_THESAURUS
C77042
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
PUBCHEM
6301
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
MERCK INDEX
m3466
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY Merck Index
NDF-RT
N0000175629
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY Increased Histamine Release [PE]
ChEMBL
CHEMBL224325
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY Cell-mediated Immunity [PE]
NDF-RT
N0000171131
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY Allergens [Chemical/Ingredient]
WIKIPEDIA
CHLORQUINALDOL
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-789-3
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
DRUG CENTRAL
3095
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
EVMPD
SUB06211MIG
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
CAS
72-80-0
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
SMS_ID
100000092132
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
CHEBI
74500
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
DRUG BANK
DB13306
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
EPA CompTox
DTXSID3048998
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
FDA UNII
D6VHC87LLS
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
DAILYMED
D6VHC87LLS
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
MESH
D002750
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
INN
215
Created by admin on Fri Dec 15 15:02:24 UTC 2023 , Edited by admin on Fri Dec 15 15:02:24 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY