Describe MRI imaging findings of hepatocellular adenomas focusing in the characteristics of each subtype according to the molecular and histopathological classification. Describe the relevance of imaging in the diagnosis and detection of hepatic adenomas to prevent complications.

Hepatocellular adenomas (HCAs) are benigns liver tumors that are more frequently seen in young women with a history of use of oral contraceptives. There are other risk factors like glycogen storage disease, use of anabolic steroids, familiar liver adenomatosis or use of anabolic steroids. Hepatic adenomas are usually reported to be solitary (70-80% of cases). Almost 50% of HCAs are diagnosed accidentally in asymptomatic patients. Large lesions can be symptomatic causing right upper abdominal quadrant fullness and discomfort and can complicate with breaking and bleeding...

We retrospectively reviewed the MRI images of patients with anatomopathological diagnosis of hepatocellular adenomas . According to recent studies, HCAs can be classificated in different subtypes depending on the different genetic and histophatological findings, and are currently categorized into three distinct subtypes: inflammatory hepatocellular adenomas, hepatocyte nuclear factor 1 alpha (HNF-1a)-mutated hepatocellular adenomas, and β-catenin-mutated hepatocellular adenoma . These subtypes show variable imaging findings in MRI. The imaging findings of these subtypes have been described in figure 1. Inflammatory hepatocellular adenomas Inflammatory hepatocellular adenoma is...

MRI is the tecnique of choice to diagnose hepatocellular adenomas and has high sensitivity and specificity identifying special features of some HCA´s subtypes ( inflammatory hepatocellular adenomas and HNF-1a-mutated hepatocellular adenomas). The new HCA molecular and histopathological classification allows to stratified patients according to the risk of complication. β-Catenin-mutated hepatocellular adenoma has a variable MRI presentation and can mimic hepatocellular carcinoma.

A. Verdu Segui; Salamanca/ES - Author at Complejo asistencial universitario de Salamanca S. Marquez Batalla; Salamanca/ES - Author at Complejo asistencial universitario de Salamanca K. Muradas Mujika; Salamanca/ES - Author at Complejo asistencial universitario de Salamanca M. Martín Izquierdo; Salamanca/ES - Author at Complejo asistencial universitario de Salamanca J. Sanz Repetto; Salamanca/ES - Author at Complejo asistencial universitario de Salamanca A. I. Sagredo Barra; Salamanca/ES - Author at Complejo asistencial universitario de Salamanca

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