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Table of Contents

December 2020

MCH induced peptide expression after heat-shock reduces dorsal melanocyte dispersion (upper left), while mchr2 homozygous mutants have extensive melanosome dispersion (lower right). Control larvae are pictured under white background (upper right) and dark background (lower left) conditions, where dark adapted larvae have more dispersed pigmentation than white adapted larvae which have contracted melanocytes. See Madelaine et al.

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Image Credit: Romain Madelaine

Research Articles

Exploiting codon usage identifies intensity-specific modifiers of Ras/MAPK signaling in vivo

Jessica K. Sawyer, Zahra Kabiri, Ruth A. Montague, Scott R. Allen, Rebeccah Stewart, Sarah V. Paramore, Erez Cohen, Hamed Zaribafzadeh, Christopher M. Counter, Donald T. Fox

Regulation of photosensation by hydrogen peroxide and antioxidants in C. elegans

Wenyuan Zhang, Feiteng He, Elizabeth A. Ronan, Hongkang Liu, Jianke Gong, Jianfeng Liu, X.Z. Shawn Xu

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage

Marta Giannini, Aleix Bayona-Feliu, Daisy Sproviero, Sonia I. Barroso, Cristina Cereda, Andrés Aguilera

Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair

Mitsutoshi Nakamura, Jeffrey M. Verboon, Tessa E. Allen, Maria Teresa Abreu-Blanco, Raymond Liu, Andrew N. M. Dominguez, Jeffrey J. Delrow, Susan M. Parkhurst

Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae

Joshua J. Black, Richa Sardana, Ezzeddine W. Elmir, Arlen W. Johnson

A viral guide RNA delivery system for CRISPR-based transcriptional activation and heritable targeted DNA demethylation in Arabidopsis thaliana

Basudev Ghoshal, Brandon Vong, Colette L. Picard, Suhua Feng, Janet M. Tam, Steven E. Jacobsen

HOX paralogs selectively convert binding of ubiquitous transcription factors into tissue-specific patterns of enhancer activation

Laure Bridoux, Peyman Zarrineh, Joshua Mallen, Mike Phuycharoen, Victor Latorre, Frank Ladam, Marta Losa, Syed Murtuza Baker, Charles Sagerstrom, Kimberly A. Mace, Magnus Rattray, Nicoletta Bobola

Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing

Swaraj Basu, Xie Xie, Jay P. Uhler, Carola Hedberg-Oldfors, Dusanka Milenkovic, Olivier R. Baris, Sammy Kimoloi, Stanka Matic, James B. Stewart, Nils-Göran Larsson, Rudolf J. Wiesner, Anders Oldfors, Claes M. Gustafsson, Maria Falkenberg, Erik Larsson

A dynamic, ring-forming MucB / RseB-like protein influences spore shape in Bacillus subtilis

Johana Luhur, Helena Chan, Benson Kachappilly, Ahmed Mohamed, Cécile Morlot, Milena Awad, Dena Lyras, Najwa Taib, Simonetta Gribaldo, David Z. Rudner, Christopher D. A. Rodrigues

A conserved role for AMP-activated protein kinase in NGLY1 deficiency

Seung Yeop Han, Ashutosh Pandey, Tereza Moore, Antonio Galeone, Lita Duraine, Tina M. Cowan, Hamed Jafar-Nejad

Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis

Corbin Quick, Xiaoquan Wen, Gonçalo Abecasis, Michael Boehnke, Hyun Min Kang

Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity

Philipp Schwabl, Jalil Maiguashca Sánchez, Jaime A. Costales, Sofía Ocaña-Mayorga, Maikell Segovia, Hernán J. Carrasco, Carolina Hernández, Juan David Ramírez, Michael D. Lewis, Mario J. Grijalva, Martin S. Llewellyn

The role of gene dosage in budding yeast centrosome scaling and spontaneous diploidization

Jingjing Chen, Zhiyong Xiong, Danny E. Miller, Zulin Yu, Scott McCroskey, William D. Bradford, Ann M. Cavanaugh, Sue L. Jaspersen

Nationwide germline whole genome sequencing of 198 consecutive pediatric cancer patients reveals a high incidence of cancer prone syndromes

Anna Byrjalsen, Thomas V. O. Hansen, Ulrik K. Stoltze, Mana M. Mehrjouy, Nanna Moeller Barnkob, Lisa L. Hjalgrim, René Mathiasen, Charlotte K. Lautrup, Pernille A. Gregersen, Henrik Hasle, Peder S. Wehner, Ruta Tuckuviene, Peter Wad Sackett, Adrian O. Laspiur, Maria Rossing, Rasmus L. Marvig, Niels Tommerup, Tina Elisabeth Olsen, David Scheie, Ramneek Gupta, Anne–Marie Gerdes, Kjeld Schmiegelow, Karin Wadt

Recombination events are concentrated in the spike protein region of Betacoronaviruses

Louis-Marie Bobay, Angela C. O’Donnell, Howard Ochman

A novel gene-diet interaction promotes organismal lifespan and host protection during infection via the mitochondrial UPR

Mustafi Raisa Amin, Siraje Arif Mahmud, Jonathan L. Dowgielewicz, Madhab Sapkota, Mark W. Pellegrino

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components

Takahiro Ide, Wang Kyaw Twan, Hao Lu, Yayoi Ikawa, Lin-Xenia Lim, Nicole Henninger, Hiromi Nishimura, Katsuyoshi Takaoka, Vijay Narasimhan, Xiumin Yan, Hidetaka Shiratori, Sudipto Roy, Hiroshi Hamada

Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma

Pilar Delgado, Ángel F. Álvarez-Prado, Ester Marina-Zárate, Isora V. Sernandez, Sonia M. Mur, Jorge de la Barrera, Fátima Sanchez-Cabo, Marta Cañamero, Antonio de Molina, Laura Belver, Virginia G. de Yébenes, Almudena R. Ramiro

Loss of endocytosis-associated RabGEF1 causes aberrant morphogenesis and altered autophagy in photoreceptors leading to retinal degeneration

Passley Hargrove-Grimes, Anupam K. Mondal, Jessica Gumerson, Jacob Nellissery, Angel M. Aponte, Linn Gieser, Haohua Qian, Robert N. Fariss, Juan S. Bonifacino, Tiansen Li, Anand Swaroop

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence

Tina Wagner, Lara Pérez-Martínez, René Schellhaas, Marta Barrientos-Moreno, Merve Öztürk, Félix Prado, Falk Butter, Brian Luke

Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant

Raymond F. Robledo, Steven L. Ciciotte, Joel H. Graber, Yue Zhao, Amy J. Lambert, Babette Gwynn, Nathaniel J. Maki, Elena C. Brindley, Emily Hartman, Lionel Blanc, Luanne L. Peters

Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density

Anna L. Swan, Christine Schütt, Jan Rozman, Maria del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R. Seavitt, Derek D. Cissell, Terrence F. Meehan, Elif F. Acar, Christopher J. Lelliott, Ann M. Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E. Braun, Heather Cater, Mary E. Dickinson, Paul Flicek, Juan Gallegos, Elena J. Ghirardello, Jason D. Heaney, Sylvie Jacquot, Connor Lally, John G. Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin McKerlie, Stephen A. Murray, Lauryl M. J. Nutter, Kristian F. Odfalk, Helen Parkinson, Jan Prochazka, Corey L. Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L. Svenson, Taylor S. Vales, Sara E. Wells, Jacqueline K. White, Radislav Sedlacek, Wolfgang Wurst, K. C. Kent Lloyd, Peter I. Croucher, Helmut Fuchs, Graham R. Williams, J. H. Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D. M. Brown, Philipp Mayer-Kuckuk, Martin Hrabe de Angelis, IMPC Consortium

The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth

Rebecca A. Alizzi, Derek Xu, Conrad M. Tenenbaum, Wei Wang, Elizabeth R. Gavis

bsAS, an antisense long non-coding RNA, essential for correct wing development through regulation of blistered/DSRF isoform usage

Sílvia Pérez-Lluch, Cecilia C. Klein, Alessandra Breschi, Marina Ruiz-Romero, Amaya Abad, Emilio Palumbo, Lyazzat Bekish, Carme Arnan, Roderic Guigó

Lotus japonicus karrikin receptors display divergent ligand-binding specificities and organ-dependent redundancy

Samy Carbonnel, Salar Torabi, Maximilian Griesmann, Elias Bleek, Yuhong Tang, Stefan Buchka, Veronica Basso, Mitsuru Shindo, François-Didier Boyer, Trevor L. Wang, Michael Udvardi, Mark T. Waters, Caroline Gutjahr

Super-resolution visualization of distinct stalled and broken replication fork structures

Donna R. Whelan, Wei Ting C. Lee, Frances Marks, Yu Tina Kong, Yandong Yin, Eli Rothenberg

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

Aabha I. Sharma, Sara H. Shin, Selina Bopp, Sarah K. Volkman, Daniel L. Hartl, Dyann F. Wirth

Physiological and genetic convergence supports hypoxia resistance in high-altitude songbirds

Ying Xiong, Liqing Fan, Yan Hao, Yalin Cheng, Yongbin Chang, Jing Wang, Haiyan Lin, Gang Song, Yanhua Qu, Fumin Lei

MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA

Xiaolong Liu, Jacob Biboy, Elisa Consoli, Waldemar Vollmer, Tanneke den Blaauwen

GATA factor-regulated solute carrier ensemble reveals a nucleoside transporter-dependent differentiation mechanism

Nicole M. Zwifelhofer, Xiaoli Cai, Ruiqi Liao, Bin Mao, Daniel J. Conn, Charu Mehta, Sunduz Keles, Yang Xia, Emery H. Bresnick

Increased virulence of Puccinia coronata f. sp.avenae populations through allele frequency changes at multiple putative Avr loci

Marisa E. Miller, Eric S. Nazareno, Susan M. Rottschaefer, Jakob Riddle, Danilo Dos Santos Pereira, Feng Li, Hoa Nguyen-Phuc, Eva C. Henningsen, Antoine Persoons, Diane G. O. Saunders, Eva Stukenbrock, Peter N. Dodds, Shahryar F. Kianian, Melania Figueroa

Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism

Benjamin P. Towler, Amy L. Pashler, Hope J. Haime, Katarzyna M. Przybyl, Sandra C. Viegas, Rute G. Matos, Simon J. Morley, Cecilia M. Arraiano, Sarah F. Newbury

A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility

Weizhe Li, Jinqing Liang, Patricia Outeda, Stacey Turner, Barbara T. Wakimoto, Terry Watnick

Genome-scale reconstruction of Gcn4/ATF4 networks driving a growth program

Rajalakshmi Srinivasan, Adhish S. Walvekar, Zeenat Rashida, Aswin Seshasayee, Sunil Laxman

Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes

Petra Horvatek, Andrea Salzer, Andrew Magdy Fekry Hanna, Fabio Lino Gratani, Daniela Keinhörster, Natalya Korn, Marina Borisova, Christoph Mayer, Dominik Rejman, Ulrike Mäder, Christiane Wolz

Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction

Emily J. Parnell, Timothy J. Parnell, Chao Yan, Lu Bai, David J. Stillman

Genomic and transcriptomic landscape of conjunctival melanoma

Katarina Cisarova, Marc Folcher, Ikram El Zaoui, Rosanna Pescini-Gobert, Virginie G. Peter, Beryl Royer-Bertrand, Leonidas Zografos, Ann Schalenbourg, Michael Nicolas, Donata Rimoldi, Serge Leyvraz, Nicolò Riggi, Alexandre P. Moulin, Carlo Rivolta

Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling

Che-Yi Lin, Mei-Yeh Jade Lu, Jia-Xing Yue, Kun-Lung Li, Yann Le Pétillon, Luok Wen Yong, Yi-Hua Chen, Fu-Yu Tsai, Yu-Feng Lyu, Cheng-Yi Chen, Sheng-Ping L. Hwang, Yi-Hsien Su, Jr-Kai Yu