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CDKN2A

  • Reference work entry
Encyclopedic Reference of Cancer

  • 195 Accesses

Synonyms

  • CDKN2

  • CDK4I

  • CMM2

  • INK4A

  • MTS1

  • p16

  • p16INK4

  • p16INK4A

  • p16INK4a

Definition

Cyclin-dependent kinase inhibitor 2A gene (CDKN2A), the first identified melanoma predisposition gene, encodes the cyclin-dependent kinase inhibitor, p16.

Characteristics

Identification of CDKN2A

The 9p21-22 chromosomal region was originally implicated in the development of melanomas through a combination of cytogenetic and loss of heterozygosity (LOH) studies. Subsequent linkage analysis in melanoma families indicated that this region harboured a melanoma predisposition locus. Homozygous deletions in cell lines derived from several different tumour types narrowed down the region significantly. This led to the isolation, by two independent groups, of the cell cycle regulatory gene encoding the cyclin-dependent kinase (CDK) inhibitor, p16, which had been previously identified in a yeast two-hybrid screen to identify proteins that bound to CDK4 (Fig. 1).

Fig. 1
figure 1_3-540-30683-8_279

CDKN2A. Alternative transcripts and products...

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References

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Author information

Authors and Affiliations

  1. Queensland Institute of Medical Research, Brisbane, Australia

    Nicholas Hayward

Authors
  1. Nicholas Hayward
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Editor information

Editors and Affiliations

  1. Division Cytogenetics - H-0400, German Cancer Research Center, Im Neuenheimer Feld, 69120, Heidelberg, Germany

    Manfred Schwab (Professor for Genetics, Director) (Professor for Genetics, Director)

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© 2001 Springer-Verlag

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Hayward, N. (2001). CDKN2A. In: Schwab, M. (eds) Encyclopedic Reference of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30683-8_279

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  • DOI: https://doi.org/10.1007/3-540-30683-8_279

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66527-4

  • Online ISBN: 978-3-540-30683-2

  • eBook Packages: Springer Book Archive

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