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Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review

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Abstract

Purpose

Acinic cell carcinoma (ACCs) is uncommon malignant epithelial neoplasm of the salivary glands; the most common presentation is a well-defined painless solid mass. Diagnosis of ACCs is frequently complicated, due to its similarity with benign tumors.

Methods

A review of the literature available on ACCs was carried out. Studies were sourced from PubMed with searching of relevant headings and sub-headings and cross-referencing.

Results

There are no clear characteristics of ACCs found on CT, MRI and ultrasound imaging. The management of the ACC, a rare malignancy of the parotid gland, is often difficult and controversial. Radical surgery is the best treatment option. The role of radiotherapy remains controversial: the precise indications and oncologic effects of adjuvant radiotherapy in ACC of the parotid gland are not well known. There is insufficient literature regarding the chemotherapy for metastatic ACC.

Conclusion

Knowledge about ACC, a rare malignancy of parotid gland, has changed over the past few decades. More clinical randomized works would be needed, both to assess the real effectiveness of radio and chemotherapy and to have an unanimous consensus about their indications.

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Author notes

  1. M. Cavaliere and P. De Luca equally contributed to this work.

Authors and Affiliations

  1. Department of Otorhinolaryngology, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy

    M. Cavaliere, L. Savignano & M. Iemma

  2. Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Via Salvator Allende 43, Salerno, Italy

    P. De Luca, A. Scarpa & E. Cassandro

  3. Surgical Sciences Department, University of Turin, Turin, Italy

    C. Cassandro

Authors
  1. M. Cavaliere
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  2. P. De Luca
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  3. A. Scarpa
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  4. L. Savignano
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  5. C. Cassandro
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  6. E. Cassandro
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Correspondence to P. De Luca.

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Cavaliere, M., De Luca, P., Scarpa, A. et al. Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review. Eur Arch Otorhinolaryngol 277, 2673–2679 (2020). https://doi.org/10.1007/s00405-020-05998-6

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  • DOI: https://doi.org/10.1007/s00405-020-05998-6

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