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Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects

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Abstract

Species of Cissampelos (Menispermaceae) are widely used in folk medicine in various cultures, for the treatment of a wide variety of diseases. Several ethnobotanical studies have reported the use of these species, which, among other benefits, instigated further researches on several pharmacological properties and biologically active compounds present in species of the genus. The objective of this review is to compile and update information about the ethnobotanical, phytochemical and biological studies of species of the Cissampelos genus. Among the officially accepted species, C. pareira, C. mucronata and C. sympodialis were the most reported in all aspects of the research. Their immunomodulatory, anti-inflammatory, antioxidant, antiallergic and antimicrobial properties have already been established. Evidently, a considerable part of these bioactivities is due to the presence of alkaloids, the main constituents of Cissampelos species. Other natural products such as essential oils, fixed oils, pectins, alcamides, polysaccharides and flavonoids have also been reported. Future investigations on Cissampelos species are necessary, especially regarding pharmacological properties, isolation of substances, mechanism of action and bioavailability in order to provide subsidies for the development of new drugs.

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Abbreviations

Ag:

Antigen

ALT:

Alanine aminotransferase

APORFIN:

Aporphic

AV:

Atrioventricular

AZAFLU:

Azafluorantene

BIQ:

Benzylisoquinolinic

BIS-BIQ:

Bisbenzylisoquinolinic

cAMP:

Adenosina 3′,5′-monofosfato cíclico

DENV’s:

Dengue virus serotypes

DPPH:

2,2-Diphenyl-1-picrylhydrazyl

ED:

Effective dose

ELISA:

Enzyme-linked immunosorbent assay

GSH:

l-glutathione

HPLC:

High performance liquid chromatography

Huh-7:

Human hepatocyte lineage

IC:

Inhibitory Concentration

IFN:

Interferon

Ig:

Immunoglobulin

IL:

Interleukin

i. p.:

Intraperitoneal

LC:

Lethal Concentration

LD:

Lethal dose

LDH:

Lactate dehydrogenase

LPS:

Lipopolysaccharide

MHC:

Major histocompatibility complex

MIC:

Minimal inhibitory concentration

MIF:

Macrophage migration inhibitory factor

MORFIN:

Morfinandnonic

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolyl bromide

NSAIDs:

Non-steroidal anti-inflammatory drugs

NO:

Nitric oxide

OVA:

Ovalbumin

OXOCAN:

Stephaoxocane

PAF:

Platelet-activating factor

PIR:

Pyrrole

p. o.:

Oral administration

PRO-APORFIN:

Pro-aporphic

PROTOB:

Tetrahydroprotoberberinic

PGE:

Prostaglandin

PMA:

Phorbol myristate acetate

SDS-PAGE:

Sodium dodecyl sulphate–polyacrylamide gel electrophoresis

TNF:

Tumor necrosis factor

TROPOLI:

Tropoloisoquinolinic

UV:

Ultraviolet

5-HT:

Serotonin

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Acknowledgements

This work was carried out at the Laboratório de Pesquisa de Produtos Naturais, Departamento de Química Biológica da Universidade Regional do Cariri (URCA), supported by the Brazilian Agency of Coordination for the Improvement of Higher Education Personnel (CAPES) and the National Council for Scientific and Technological Development. (CNPq).

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Brazilian Agency of Coordination for the Improvement of Higher Education Personnel (CAPES) and National Council for Scientific and Technological Development. (CNPq).

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  1. Departamento de Química Biológica, Laboratório de Pesquisa de Produtos Naturais, Universidade Regional Do Cariri, Rua Coronel Antônio Luíz, 1161 - Pimenta, Crato, Ceará, 63105-010, Brazil

    Johnatan Wellisson da Silva Mendes, Walmir Emanuel Miranda Cunha, Fábio Fernandes Galvão Rodrigues, Roberta Dávila Pereira de Lima & José Galberto Martins da Costa

  2. Departamento de Química Orgânica E Inorgânica, Universidade Federal Do Ceará, Campus Do Pici, Bloco 940, Bairro Pici, Fortaleza, Ceará, 60451-970, Brazil

    Edilberto Rocha Silveira

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da Silva Mendes, J.W., Cunha, W.E.M., Rodrigues, F.F.G. et al. Cissampelos genus: biological activities, ethnobotanical and phytochemical aspects. Phytochem Rev 19, 955–982 (2020). https://doi.org/10.1007/s11101-020-09695-4

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