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Diagnosis and treatment of herpangina: Chinese expert consensus

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Abstract

Background

Herpangina is a common infectious disease in childhood caused by an enterovirus. This consensus is aiming to standardize and improve herpangina prevention and clinical diagnosis.

Methods

The Subspecialty Group of Infectious Diseases, the Society of Pediatric, Chinese Medical Association and Nation Medical Quality Control Center for Infectious Diseases gathered 20 experts to develop the consensus, who are specialized in diagnosis and treatment of herpangina.

Results

The main pathogenic serotypes of herpangina include Coxsackievirus-A, Enterovirus-A and Echovirus. Its diagnosis can be rendered on the basis of history of epidemiology, typical symptoms, characteristic pharyngeal damage and virological tests. The treatment is mainly symptomatic, and incorporates topical oral spray with antiviral drugs. The course of herpangina generally lasts 4–6 days with a good prognosis.

Conclusion

The consensus could provide advices and references for the diagnosis, treatment and management of herpangina in children.

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References

  1. Chen C. Clinical and epidemiological features of herpangina. Inter J Epidemiol Infect Dis. 2016;43:270–3 (in Chinese).

    Google Scholar 

  2. Jiang DF, Shen KL, Shen Y. Zhu futang practice of pediatrics. 8th ed. Beijing: People’s Medical Publishing House; 2015 (in Chinese).

    Google Scholar 

  3. Li JM, Li L, Gao L, Dong XC, Liu H. Characteristics of herpangina epidemic and related environmental impact factors in Tianjin. J Environ Health. 2018;35:326–9 (in Chinese).

    Google Scholar 

  4. Li W, Gao HH, Zhang Q, Liu YJ, Tao R, Cheng YP, et al. Large outbreak of herpangina in children caused by enterovirus in summer of 2015 in Hangzhou China. Sci Rep. 2016;6:35388.

    Article  CAS  Google Scholar 

  5. Peng Q, Xie MY, Zhang YH, Liu Q, Li WR, Li SP, et al. Molecular epidemiology of the enteroviruses associated with hand, foot and mouth disease/herpangina in Dongguan, China, 2015. Arch Virol. 2016;161:3463–71.

    Article  CAS  Google Scholar 

  6. Yao X, Bian LL, Lu WW, Li JX, Mao QY, Wang YP, et al. Epidemiological and etiological characteristics of herpangina and hand foot mouth diseases in Jiangsu, China, 2013–2014. Hum Vaccin Immunother. 2017;13:823–30.

    Article  Google Scholar 

  7. Zeng HR, Zheng HY, Liu L, Lu J, Tan XH, Sun LM, et al. Etiological characteristics of herpangina cases in Guangzhou city in Guangdong province, 2015. Chin J Exp Clin Virol. 2017;31:409–13 (in Chinese).

    Google Scholar 

  8. Puenpa J, Mauleekoonphairoj J, Linsuwanon P, et al. Prevalenceand characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenzalike illness in Thailand, 2012. PLoS One. 2014;906:9888.

    Google Scholar 

  9. Li XW, Ni X, Qian SY, Wang Q, Jiang RM, Xu WB, et al. Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition). World J Pediatr. 2018;36:257–63.

    Google Scholar 

  10. Wang WP, Sun K, Chang LW. Pediatrics. In: Qu SQ, editor. Acute upper respiratory infection. 9th ed. Beijing: People’s Medical Publishing House; 2018. p. 240–2 (in Chinese).

    Google Scholar 

  11. Takechi M, Fukushima W, Nakano T, Inui1 M, Ohfuji S, Kase T, et al. Nationwide Survey of Pediatric inpatients with hand, foot, and mouth disease, herpangina, and associated complications during an epidemic period in Japan: estimated number of hospitalized patients and factors associated with severe cases. J Epidemiol; 2018.

  12. Deng HL, Jiang RM, Li XW, Qian SY, Wang Q, Chen Q, et al. Differential diagnosis of hand-foot-mouth disease. Chin J Clin. 2018;46:760–3 (in Chinese).

    Google Scholar 

  13. Lin H, Huang L, Zhou J, Lin KC, Wang HJ, Xue X, et al. Efficacy and safety of interferon-α2b spray in the treatment of hand, foot, and mouth disease: a multicenter, randomized, double-blind trial. Arch Virol. 2016;161:1–8.

    Article  CAS  Google Scholar 

  14. Yao TX, Liao YN, Gu F, Yu SJ, Yin F. Clinical effect of recombinant human interferon α-2b spray on herpangina in children. Chin Pediatr Integr Tradit West Med. 2017;9:427–9 (in Chinese).

    Google Scholar 

  15. Mangan NE, Fung KY. Type I interferons in regulation of mucosal immunity. Immunol Cell Biol. 2012;90:510–9.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The Chinese version of this Expert consensus was published in the March issue of Chin J Pediatr in 2019.

Funding

None.

Author information

Authors and Affiliations

  1. Department of Infectious Diseases, Children’s Hospital of Fudan University, Shanghai, China

    Hui Yu & Ying-Zi Ye

  2. Infectious Disease Diagnosis and Treatment Center, Beijing Ditan Hospital Capital Medical University, Beijing, China

    Xing-Wang Li, Rong-Meng Jiang & Xiao-Dong Liu

  3. Department of Infectious Diseases, Children’s Hospital of Chongqing Medical University, Chongqing, China

    Quan-Bo Liu

  4. Department of Infectious Diseases, The Children’s Hospital of Xi’an, Xi’an, China

    Hui-Ling Deng

  5. Department of Infectious Diseases, Beijing Children’s Hospital, Capital Medical University, Beijing, China

    Gang Liu

  6. Department of Infectious Diseases, Shenzhen Children’s Hospital, Shenzhen, China

    Ji-Kui Deng

  7. Department of Internal Medicine, Children’s Hospital of Kaifeng City, Kaifeng, China

    Jian-Hua Hao

  8. Department of Infectious Diseases, The Children’s Hospital-Zhejiang University School of Medicine, Hangzhou, China

    Ying-Hu Chen

  9. Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China

    Guang-Min Nong

  10. Pneumology Department, Henan Children’s Hospital, Henan, China

    Zhao-Bo Shen

  11. Department of Pediatrics, The Second Hospital of Tianjin Medical University, Tianjin, China

    Chang-Shan Liu

  12. Department of Infectious Diseases, Tianjin Children’s Hospital, Tianjin, China

    Ying-Xue Zou

  13. Department of Pediatric Pneumology, The First Affiliated Hospital of Xiamen University, Xiamen, China

    Jin-Zhun Wu

  14. Department of Pediatrics, Xiamen Maternal and Child Health Care Hospital, Xiamen, China

    Xing-Dong Wu

  15. Department of Infectious Diseases, Anhui Provincial Children’s Hospital, Hefei, China

    Bi-Quan Chen

  16. Department of Infectious Diseases, Hunan Children’s Hospital, Hunan, China

    Ru-Ping Luo

  17. Department of Infectious Diseases, Qilu Children’s Hospital of Shandong University, Shandong, China

    Ai-Wei Lin

  18. Department of Pediatrics Internal Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China

    Yan Chen

Authors
  1. Hui Yu
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  2. Xing-Wang Li
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  3. Quan-Bo Liu
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  4. Hui-Ling Deng
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  5. Gang Liu
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  6. Rong-Meng Jiang
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  7. Ji-Kui Deng
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  8. Ying-Zi Ye
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  9. Jian-Hua Hao
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  10. Ying-Hu Chen
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  11. Guang-Min Nong
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  12. Zhao-Bo Shen
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  13. Chang-Shan Liu
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  14. Ying-Xue Zou
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  15. Jin-Zhun Wu
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  16. Xing-Dong Wu
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  17. Bi-Quan Chen
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  18. Ru-Ping Luo
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  19. Ai-Wei Lin
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  20. Yan Chen
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  21. Xiao-Dong Liu
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Contributions

All the other authors confirmed the final version of the consensus. HY chief trial. HY and XWL chief editor. QBL, RMJ, HLD, GL deputy chief editor. YZY, XDL secretry. Committee members (Ranking in alphabetical order according to last name): BQC, YC, YHC, HLD, JKD, JHH, RMJ, XWL, AWL, CSL, GL, QBL, RPL, GMN, ZBS, JZW, XDW, YZY, HY, YXZ.

Corresponding author

Correspondence to Hui Yu.

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Cite this article

Yu, H., Li, XW., Liu, QB. et al. Diagnosis and treatment of herpangina: Chinese expert consensus. World J Pediatr 16, 129–134 (2020). https://doi.org/10.1007/s12519-019-00277-9

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  • DOI: https://doi.org/10.1007/s12519-019-00277-9

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