Abstract
Among analgesic drugs, the opioid class of compounds still remains one of the most important medicines for severe and chronic pain treatment. Hence, developing novel and effective synthetic method of morphine and its related compounds is still an important task in modern synthetic organic chemistry. Achieving this goal demands a comprehensive knowledge of these valuable alkaloids. The present review study aims to summarize the history of five major opioid alkaloids and their pharmacologic effects, as well as various synthetic and biosynthetic methods.
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Kaboudin, B., Sohrabi, M. Chemistry and synthesis of major opium alkaloids: a comprehensive review. J IRAN CHEM SOC 18, 3177–3218 (2021). https://doi.org/10.1007/s13738-021-02268-y
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DOI: https://doi.org/10.1007/s13738-021-02268-y