Abstract
Platonia insignis Mart., Clusiaceae, or the bacuri tree is found in the Amazon rainforest and several countries of South America. The tree is known for its solid timber, its edible fruit, and some derived products such as the bacuri seed butter used in phytotherapeutic preparations and cosmetics. Many bioactive natural products have been isolated from the bacuri tree, in particular the polycyclic prenylated acylphloroglucinol–designated garcinielliptone FC, initially isolated from Garcinia subelliptica Merr. (like the 32 garcinielliptones known to date), but it can be isolated also from the seeds and fruits of bacuri. We have reviewed the pharmacological properties of this under-exploited natural product which displays antioxidant, vasorelaxant, anticonvulsive, antiparasitic, and anticancer properties, all discussed here. The marked antiproliferative activities of garcinielliptone FC against various cancer cell lines, and the structural analogy with tumor active prenylated acylphloroglucinols, such as hyperforin and nemorosone, argue in favor of further in vivo evaluations of this active metabolite against solid tumors and leukemia. By analogy with other prenylated acylphloroglucinols, the chaperone protein HSPA8 is proposed as a molecular target for garcinielliptone FC. The compound is recognized as being safe and well-tolerated in rodent species according to toxicology studies. Altogether, the review shed light on the pharmacological interest of garcinielliptone FC and bacuri fruits.
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Allegra A, Tonacci A, Spagnolo EV, Musolino C, Gangemi S (2020) Antiproliferative effects of St. John’s wort, its derivatives, and other Hypericum species in hematologic malignancies. Int J Mol Sci 22:146. https://doi.org/10.3390/ijms22010146
Aniceto A, Porte A, Montenegro J, Cadena RS, Teodoro AJ (2017) A review of the fruit nutritional and biological activities of three Amazonian species: bacuri (Platonia insignis), murici (Byrsonima spp.), and taperebá (Spondias mombin). Fruits 72:317–326. https://revues.cirad.fr/index.php/fruits/article/view/32054/31653. Accessed 17 Mar 2022
Arcanjo DD, da Costa-Júnior JS, Moura LH, Ferraz AB, Rossatto RR, David JM, Quintans-Júnior LJ, Oliveira Rde C, Citó AM, de Oliveira AP (2014) Garcinielliptone FC, a polyisoprenylated benzophenone from Platonia insignis Mart., promotes vasorelaxant effect on rat mesenteric artery. Nat Prod Res 28:923–927. https://doi.org/10.1080/14786419.2014.889136
Bailly C, Vergoten G (2021) Anticancer properties and mechanism of action of oblongifolin C, guttiferone K and related polyprenylated acylphloroglucinols. Nat Prod Bioprospect 11:629–641. https://doi.org/10.1007/s13659-021-00320-1
Bezerra ÉA, Alves MMM, Amorim LV, Carvalho RCV, Cruz LPL, Costa-Júnior JS, Oliveira MDDA, Lima Neto JS, Carvalho FAA, Citó AMDGL, Arcanjo DDR (2020) Garcinielliptone FC: selective anti-amastigote and immunomodulatory effects on macrophages infected by Leishmania amazonensis. Toxicol In Vitro 63:104750. https://doi.org/10.1016/j.tiv.2019.104750
Bezerra ÉA, Alves MMM, Lima SKR, Pinheiro EEA, Amorim LV, Lima Neto JS, Carvalho FAA, Citó AMDGL, Arcanjo DDR (2021) Biflavones from Platonia insignis Mart. flowers promote in vitro antileishmanial and immunomodulatory effects against internalized amastigote forms of Leishmania amazonensis. Pathogens 10:1166. https://doi.org/10.3390/pathogens10091166
Billard C, Merhi F, Bauvois B (2013) Mechanistic insights into the antileukemic activity of hyperforin. Curr Cancer Drug Targets 13:1–10. https://doi.org/10.2174/1568009611309010001
Boyce JH, Reisman BJ, Bachmann BO, Porco JA Jr (2021) Synthesis and multiplexed activity profiling of synthetic acylphloroglucinol scaffolds. Angew Chem Int Ed Engl 60:1263–1272. https://doi.org/10.1002/anie.202010338
Buchholzer ML, Dvorak C, Chatterjee SS, Klein J (2002) Dual modulation of striatal acetylcholine release by hyperforin, a constituent of St. John’s wort. J Pharmacol Exp Ther 301:714–719. https://doi.org/10.1124/jpet.301.2.714
Chen B, Akamine H (2021) Distribution and utilization of homestead windbreak Fukugi (Garcinia subelliptica Merr.) trees: an ethnobotanical approach. J Ethnobiol Ethnomed 17:11. https://doi.org/10.1186/s13002-021-00434-3
Chrubasik-Hausmann S, Vlachojannis J, McLachlan AJ (2019) Understanding drug interactions with St John’s wort (Hypericum perforatum L.): impact of hyperforin content. J Pharm Pharmacol. 71:129–138. https://doi.org/10.1111/jphp.12858
Coêlho ES, Lopes GLN, Pinheiro IM, Holanda JNP, Alves MMM, Carvalho Nogueira N, Carvalho FAA, Carvalho ALM (2018) Emulgel based on amphotericin B and bacuri butter (Platonia insignis Mart.) for the treatment of cutaneous leishmaniasis: characterization and in vitro assays. Drug Dev Ind Pharm 44:1713–1723. https://doi.org/10.1080/03639045.2018.1492610
Coelho VR, Prado LS, Rossato RR, Ferraz ABF, Vieira CG, de Souza LP, Pfluger P, Regner GG, Valle MTC, Leal MB, Dallegrave E, Corrêa DS, Picada JN, Pereira P (2018) A 28-day sub-acute genotoxic and behavioural assessment of garcinielliptone FC. Basic Clin Pharmacol Toxicol 123:207–212. https://doi.org/10.1111/bcpt.13010
Coelho AG, Dos Santos WRP, Dos Santos AA, da Silva MG, Cunha FVM, Mendes AN, Arcanjo DDR (2020) Plant-derived butters as lipid nanocarriers: a systematic and prospective review. Recent Pat Nanotechnol 14:262–275. https://doi.org/10.2174/1872210514666200522213144
Cordenonsi LM, Santer A, Sponchiado RM, Wingert NR, Raffin RP, Schapoval EES (2019a) Amazonia products in novel lipid nanoparticles for fucoxanthin encapsulation. AAPS PharmSciTech 21:32. https://doi.org/10.1208/s12249-019-1601-y
Cordenonsi LM, Faccendini A, Catanzaro M, Bonferoni MC, Rossi S, Malavasi L, Platcheck Raffin R, Scherman Schapoval EE, Lanni C, Sandri G, Ferrari F (2019b) The role of chitosan as coating material for nanostructured lipid carriers for skin delivery of fucoxanthin. Int J Pharm 567:118487. https://doi.org/10.1016/j.ijpharm.2019.118487
Costa Júnior JS, Ferraz ABF, Filho BAB, Feitosa CM, Citó AMGL, Freitas RM, Saffi J (2011) Evaluation of antioxidant effects in vitro of garcinielliptone FC (GFC) isolated from Platonia insignis Mart. J Med Plants Res 5:293–299.
Costa Júnior JS, de Almeida AAC, Falcão Ferraz AB, Rossatto RR, Silva TG, Silva PBN, Militão GCG, das Graças Lopes Citó AM, LCL RS, de Amorim Carvalho FA, Freitas RM (2012) Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis. Nat Prod Res 2012:. Formerly Nat Prod Lett:470–474. https://doi.org/10.1080/14786419.2012.695363
Costa Júnior JS, Ferraz AB, Sousa TO, Silva RA, De Lima SG, Feitosa CM, Citó AM, Melo Cavalcante AA, Freitas RM, Moura Sperotto AR, Péres VF, Moura DJ, Saffi J (2013a) Investigation of biological activities of dichloromethane and ethyl acetate fractions of Platonia insignis Mart. seed. Basic Clin Pharmacol Toxicol 112:34–41. https://doi.org/10.1111/j.1742-7843.2012.00924.x
Costa Júnior JS, de Almeida AA, de Barros Falcão Ferraz A, Rossatto RR, Silva TG, Silva PB, Militão GC, das Graças Lopes Citó AM, Santana LC, de Amorim Carvalho FA, Freitas RM (2013b) Cytotoxic and leishmanicidal properties of garcinielliptone FC, a prenylated benzophenone from Platonia insignis. Nat Prod Res 27:470–474. https://doi.org/10.1080/14786419.2012.695363
da Costa Júnior JS, de Almeida AA, Costa JP, das Graças Lopes Citó AM, Saffi J, de Freitas RM (2012) Superoxide dismutase and catalase activities in rat hippocampus pretreated with garcinielliptone FC from Platonia insignis. Pharm Biol 50:453–457. https://doi.org/10.3109/13880209.2011.611146
da Silva Prado L, da Silva J, Garcia ALH, Boaretto FBM, Grivicich I, Conter LU, de Oliveira Salvi A, Reginatto FH, Vencato SB, de Barros Falcão Ferraz A, Picada JN (2017) Evaluation of DNA damage in HepG2 cells and mutagenicity of garcinielliptone FC, a bioactive benzophenone. Basic Clin Pharmacol Toxicol 120:621–627. https://doi.org/10.1111/bcpt.12753
da Silva AP, Lopes JS, Vieira Pde S, Pinheiro EE, da Silva ML, Silva Filho JC, da Costa JS Jr, David JM, de Freitas RM (2014) Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Pharmacol Biochem Behav 124:305–310. https://doi.org/10.1016/j.pbb.2014.05.021
da Silva AP, Oliveira GL, Medeiros SC, Sousa AM, Lopes Lda S, David JM, da Costa Junior JS, de Freitas RM (2016) Pre-clinical toxicology of garcinielliptone FC, a tautomeric pair of polyprenylated benzophenone, isolated from Platonia insignis Mart seeds. Phytomedicine 23:477–482. https://doi.org/10.1016/j.phymed.2016.02.013
Díaz-Carballo D, Malak S, Freistühler M, Elmaagacli A, Bardenheuer W, Reusch HP (2008) Nemorosone blocks proliferation and induces apoptosis in leukemia cells. Int J Clin Pharmacol Ther 46:428–439. https://doi.org/10.5414/CPP46428
Dos Santos VB, da Silva EKN, de Oliveira LMA, Suarez WT (2019) Low cost in situ digital image method, based on spot testing and smartphone images, for determination of ascorbic acid in Brazilian Amazon native and exotic fruits. Food Chem 285:340–346. https://doi.org/10.1016/j.foodchem.2019.01.167
Feitosa JM, Silva TSA, Xavier AEF, Rodrigues WCS, Silva ACE, Corrêa CVP, Aguiar FS, Mourão RHV, Oliveira EG, Nunes KM (2021) Evaluation of the quality of Amazonian butters as sustainable raw materials for applications in bioproducts. Rev Ciênc Farm Básica Apl 42:e708. https://doi.org/10.4322/2179-443X.0708
Gaid M, Biedermann E, Füller J, Haas P, Behrends S, Krull R, Scholl S, Wittstock U, Müller-Goymann C, Beerhues L (2018) Biotechnological production of hyperforin for pharmaceutical formulation. Eur J Pharm Biopharm 126:10–26. https://doi.org/10.1016/j.ejpb.2017.03.024
Grossman RB (2022) Table of naturally occurring PPAPs. http://www.chem.uky.edu/research/grossman/PPAPs. Accessed 6 February 2022
Grossman RB, Yang XW (2020) Structural revision of garcinielliptin oxide and garcinielliptone E. J Nat Prod 83:2041–2044. https://doi.org/10.1021/acs.jnatprod.0c00306
Guo Y, Cao Y, Qi C, Tong Q, Chen C, Yang J, Zhu H, Zhang Y (2021) Polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum perforatum and absolute configurations assignment of previously reported analogues. Bioorg Chem 114:105144. https://doi.org/10.1016/j.bioorg.2021.105144
Gurevich AI, Dobrynin VN, Kolosov MN, Popravko SA, Ryabova ID, Chernov BK, Derbentseva NA, Aizenman BE, Garagulya AD (1971) Hyperforin, an antibiotic from Hypericum perforatum L. Antibiotiki Khimioterapi 16:510–513
Han L, Xu D, Xi Z, Wu M, Nik Nabil WN, Zhang J, Sui H, Fu W, Zhou H, Lao Y, Xu G, Guo C, Xu H (2020) The natural compound oblongifolin C exhibits anticancer activity by inhibiting HSPA8 and cathepsin B in vitro. Front Pharmacol 11:564833. https://doi.org/10.3389/fphar.2020.564833
Inoue T, Kainuma M, Baba K, Oshiro N, Kimura N, Chan EW (2017) Garcinia subelliptica Merr. (Fukugi): a multipurpose coastal tree with promising medicinal properties. J Intercult Ethnopharmacol 6:121–127. https://doi.org/10.5455/jice.20161229060034
Ito T, Yokota R, Watarai T, Mori K, Oyama M, Nagasawa H, Matsuda H, Iinuma M (2013) Isolation of six isoprenylated biflavonoids from the leaves of Garcinia subelliptica. Chem Pharm Bull (Tokyo) 61:551–558. https://doi.org/10.1248/cpb.c12-01057
Kiewert C, Buchholzer ML, Hartmann J, Chatterjee SS, Klein J (2004) Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John’s Wort. Neurosci Lett 364:195–198. https://doi.org/10.1016/j.neulet.2004.04.046
Kim KH, Lee JY, Li WY, Lee S, Jeong HS, Choi JY, Joo M (2021) The ethanol extract of Garcinia subelliptica Merr. induces autophagy. BMC Complement Med Ther 21:280. https://doi.org/10.1186/s12906-021-03454-4
Lee SK, Kim JE, Kim YJ, Kim MJ, Kang TC (2014) Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus. Neurosci Res 85:39–50. https://doi.org/10.1016/j.neures.2014.05.006
Liaw CC, Chang JL, Wang BW, Chen PL, Weng JR, Lin KW, Lin CN (2019) Discovering a racemate polycyclic prenylated acylphloroglucinol with unprecedented skeleton by an ESI-LCMS analytical approach. Org Lett 21:857–861. https://doi.org/10.1021/acs.orglett.8b03445
Lima GM, Brito AKDS, de Farias LM, Rodrigues LARL, Pereira CFC, Lima SKR, Frota KMG, Rizzo MDS, Nunes PHM, Lucarini M, Durazzo A, Arcanjo DDR, Martins MDCCE (2021) Effects of “Bacuri” seed butter (Platonia insignis Mart.) on metabolic parameters in hamsters with diet-induced hypercholesterolemia. Evid Based Complement Alternat Med 2021:5584965. https://doi.org/10.1155/2021/5584965
Lin KW, Huang AM, Tu HY, Weng JR, Hour TC, Wei BL, Yang SC, Wang JP, Pu YS, Lin CN (2009) Phloroglucinols inhibit chemical mediators and xanthine oxidase, and protect cisplatin-induced cell death by reducing reactive oxygen species in normal human urothelial and bladder cancer cells. J Agric Food Chem 57:8782–8787. https://doi.org/10.1021/jf900935n
Lin KW, Huang AM, Yang SC, Weng JR, Hour TC, Pu YS, Lin CN (2012) Cytotoxic and antioxidant constituents from Garcinia subelliptica. Food Chem 135:851–859. https://doi.org/10.1016/j.foodchem.2012.04.133
Liu YC, Lin KH, Hsieh JH, Chung JG, Tan ZL, Hsu FT, Chiang CH (2019) Hyperforin induces apoptosis through extrinsic/intrinsic pathways and inhibits NF-qB-modulated survival and invasion potential in bladder cancer. In Vivo 33:1865–1877. https://doi.org/10.21873/invivo.11680
Liu Z, Zheng W, Liu Y, Zhou B, Zhang Y, Wang F (2021) Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells. Exp Cell Res 405:112708. https://doi.org/10.1016/j.yexcr.2021.112708
Lu YH, Wei BL, Ko HH, Lin CN (2008) DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants. Phytochemistry 69:225–233. https://doi.org/10.1016/j.phytochem.2007.06.026
Lustosa AKMF, Arcanjo DDR, Ribeiro RG, Rodrigues KAF, Passo FFB, Piauilino CA, Silva-Filho JC, Araújo BQ, Lima-Neto JS, Costa-Júnior JS, Carvalho FAA, das Graças L, Citó AM (2016) Immunomodulatory and toxicological evaluation of the fruit seeds from Platonia insignis, a native species from Brazilian Amazon Rainforest. Rev Bras Farmacogn 26:77–82. https://doi.org/10.1016/j.bjp.2015.05.014
Lustosa AKMF, Silva FV, Silva ERS, Mendes AN, Sousa LR, Carvalho ALM, Oliveira RCM, Carvalho FAA, Arcanjo DDR, Citó AMGL (2020) Lecithin-based organogel for an industrialized butter from Platonia insignis Mart. seeds and its anti-inflammatory potential: Formulation and preclinical studies. J Global Innov 2:eJGI000011
Magalhães LG, Kapadia GJ, da Silva Tonuci LR, Caixeta SC, Parreira NA, Rodrigues V, Da Silva Filho AA (2010) In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms. Parasitol Res 106:395–401. https://doi.org/10.1007/s00436-009-1674-8
Monzote L, Lackova A, Staniek K, Cuesta-Rubio O, Gille L (2015) Role of mitochondria in the leishmanicidal effects and toxicity of acyl phloroglucinol derivatives: nemorosone and guttiferone A. Parasitology 142:1239–1248. https://doi.org/10.1017/S0031182015000608
Paraense LCR, Pena DN, Darnet SH, de Miranda Rodrigues S, de Menezes IC, Moura EF (2020) First genomic microsatellite markers developed for Platonia insignis (Clusiaceae), a Brazilian fruit tree. Mol Biol Rep 47:2985–2989. https://doi.org/10.1007/s11033-020-05301-0
Pochwat B, Szewczyk B, Kotarska K, Rafało-Ulińska A, Siwiec M, Sowa JE, Tokarski K, Siwek A, Bouron A, Friedland K, Nowak G (2018) Hyperforin potentiates antidepressant-like activity of lanicemine in mice. Front Mol Neurosci 11:456. https://doi.org/10.3389/fnmol.2018.00456
Rai R, Kennedy AL, Isingizwe ZR, Javadian P, Benbrook DM (2021) Similarities and differences of Hsp70, hsc70, Grp78 and mortalin as cancer biomarkers and drug targets. Cells 10:2996. https://doi.org/10.3390/cells10112996
Richard JA, Pouwer RH, Chen DY (2012) The chemistry of the polycyclic polyprenylated acylphloroglucinols. Angew Chem Int Ed Engl 51:4536–4561. https://doi.org/10.1002/anie.201103873
Rothley M, Schmid A, Thiele W, Schacht V, Plaumann D, Gartner M, Yektaoglu A, Bruyère F, Noël A, Giannis A, Sleeman JP (2009) Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo. Int J Cancer 125:34–42. https://doi.org/10.1002/ijc.24295
Shen X, Thach DQ, Ting CP, Maimone TJ (2021) Annulative methods in the synthesis of complex meroterpene natural products. Acc Chem Res 54:583–594. https://doi.org/10.1021/acs.accounts.0c00781
Silva AP, Silva MP, Oliveira CG, Monteiro DC, Pinto PL, Mendonça RZ, Costa Júnior JS, Freitas RM, de Moraes J (2015) Garcinielliptone FC: antiparasitic activity without cytotoxicity to mammalian cells. Toxicol In Vitro 29:681–687. https://doi.org/10.1016/j.tiv.2014.12.014
Souza IG, Souza VA, Lima PS (2013) Molecular characterization of Platonia insignis Mart. (“bacurizeiro”) using inter simple sequence repeat (ISSR) markers. Mol Biol Rep 40:3835–3845. https://doi.org/10.1007/s11033-012-2462-6
Souza AC, Alves MMM, Brito LM, Oliveira LGC, Sobrinho-Júnior EPC, Costa ICG, Freitas SDL, Rodrigues KADF, Chaves MH, Arcanjo DDR, Carvalho FAA (2017, 2017) Platonia insignis Mart., a Brazilian Amazonian plant: the stem barks extract and its main constituent lupeol exert antileishmanial effects involving macrophages activation. Evid Based Complement Alternat Med:3126458. https://doi.org/10.1155/2017/3126458
Sun G, Cao Y, Dai X, Li M, Guo J (2019) Hsc70 Interacts with β4GalT5 to regulate the growth of gliomas. Neuromolecular Med 21:33–41. https://doi.org/10.1007/s12017-018-08520-8
Ting CP, Maimone TJ (2015) Total synthesis of hyperforin. J Am Chem Soc 137:10516–10519
Urano de Carvalho JE, do Nascimento WMO (2018) Technological innovations in the propagation of Açaí palm and Bacuri. Rev Bras Frutic 240:e-679. https://doi.org/10.1590/0100-29452018679
Wang S, Wang S, Wang Y, Xin Y, Zhang J, Yang Z, Liu C (2021) Hyperforin alleviates the psychiatric disorders of adult rats suffered from early maternal separation via activating autophagy. Neurosci Lett 750:135750. https://doi.org/10.1016/j.neulet.2021.135750
Wen S, Boyce JH, Kandappa SK, Sivaguru J, Porco JA Jr (2019) Regiodivergent photocyclization of dearomatized acylphloroglucinols: asymmetric syntheses of (-)-nemorosone and (-)-6-epi-garcimultiflorone A. J Am Chem Soc 141:11315–11321. https://doi.org/10.1021/jacs.9b05600
Wolf RJ, Hilger RA, Hoheisel JD, Werner J, Holtrup F (2013) In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One 8:74555. https://doi.org/10.1371/journal.pone.0074555
Won SJ, Lin TY, Yen CH, Tzeng YH, Liu HS, Lin CN, Yu CH, Wu CS, Chen JT, Chen YT, Huang CYF, Su CL (2016) A novel natural tautomeric pair of garcinielliptone FC suppressed nuclear factor κB and induced apoptosis in human colorectal cancer cells. J Functional Foods 24:568–578. https://doi.org/10.1016/j.jff.2016.05.003
Won SJ, Yen CH, Lin TY, Jiang-Shieh YF, Lin CN, Chen JT, Su CL (2018) Autophagy mediates cytotoxicity of human colorectal cancer cells treated with garcinielliptone FC. J Cell Physiol 233:497–505. https://doi.org/10.1002/jcp.25910
Wu CC, Lu YH, Wei BL, Yang SC, Won SJ, Lin CN (2008) Phloroglucinols with prooxidant activity from Garcinia subelliptica. J Nat Prod 71:246–250. https://doi.org/10.1021/np070507o
Yamaguchi KKL, Dias DS, Lamarão CV, Castelo KFA, Lima MS, Antonio AS, Converti A, Lima ES, Veiga-Junior VF (2021) Amazonian Bacuri (Platonia insignis Mart.) fruit waste valorisation using response surface methodology. Biomolecules 11:1767. https://doi.org/10.3390/biom11121767
Yang XW, Grossman RB, Xu G (2018) Research progress of polycyclic polyprenylated acylphloroglucinols. Chem Rev 118:3508–3558. https://doi.org/10.1021/acs.chemrev.7b00551
Yun Y, Shioura M, Hitotsuyanagi Y, Yotsumoto S, Takahashi Y, Aoyagi Y, Kinoshita T, Takeya K, Inoue H (2021) Garcinielliptone G from Garcinia subelliptica induces apoptosis in acute leukemia cells. Molecules 26:2422. https://doi.org/10.3390/molecules26092422
Zask A, Ellestad GA (2021) Reflections on the intriguing occurrence of some recently isolated natural products as racemates and scalemic mixtures. Chirality 33:915–930. https://doi.org/10.1002/chir.23360
Zhang LJ, Chiou CT, Cheng JJ, Huang HC, Kuo LM, Liao CC, Bastow KF, Lee KH, Kuo YH (2010) Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica. J Nat Prod 73:557–562
Zheng C, Wang X, Fu W, Lu Y, Tan H, Xu H (2018) Total synthesis of norsampsones A and B, garcinielliptones N and O, and hyperscabrin A. J Nat Prod 81:2582–2589. https://doi.org/10.1021/acs.jnatprod.8b00763
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MNCS is a research fellow of the Conselho Nacional de Desenvolvimento Científico e Tecnológico and Cientista do Nosso Estado da Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ).
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CBA conceptualized, conducted the study, and drafted an initial version of the manuscript. GV performed the molecular modeling analysis. MNCS completed and finalized the manuscript. All authors have read and approved the final submission.
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de Nazaré Correia Soeiro, M., Vergoten, G. & Bailly, C. Pharmacological Profile of Garcinielliptone FC from Platonia insignis. Rev. Bras. Farmacogn. 32, 344–354 (2022). https://doi.org/10.1007/s43450-022-00248-8
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DOI: https://doi.org/10.1007/s43450-022-00248-8