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Epidemiology of Oral and Oropharyngeal Cancers

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Textbook of Oral Cancer

Part of the book series: Textbooks in Contemporary Dentistry ((TECD))

Abstract

With an estimated 500,000 new cases each year worldwide and rising trends reported in many countries, particularly among the young, focused public health measures are needed to reduce the incidence of and mortality from oral and oropharyngeal cancer. There is considerable variation in the global incidence patterns, reflecting population lifestyles in each country. The aim of this chapter collating global epidemiological evidence is to stimulate research and policy development and to highlight appropriate strategies to reduce the oral cancer burden worldwide.

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References

  1. Forman D, Bray F, Brewster DH, GombeMbalawa C, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Ferlay J, editors. Cancer incidence in five continents, Vol. X. Lyon: International Agency for Research on Cancer. Available from: http://ci5.iarc.fr. Accessed 1 Feb 2018.

  2. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.

    Article  PubMed  Google Scholar 

  3. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I, Bray F. Global cancer observatory: cancer today. Lyon, France: International Agency for Research on Cancer; 2018. Available from: https://gco.iarc.fr/today. Accessed 07/01/2019.

    Google Scholar 

  4. National Cancer Institute. The Surveillance, Epidemiology, and End Results (SEER) Program. https://seer.cancer.gov/. Accessed 1 Feb 2018.

  5. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018 Jan;68(1):7–30.

    Article  PubMed  Google Scholar 

  6. European Cancer Observatory (ECO) at International Agency for Research on Cancer (IARC). http://eco.iarc.fr/EUREG/Default.aspx. accessed 1 Feb 2018.

  7. Global Oral Cancer Forum. http://globaloralcancerforum.org/. Accessed 1 Feb 2018.

  8. Taiwan Cancer Registry; https://www.hpa.gov.tw/Pages/Detail.aspx?nodeid=269&pid=8084, p8. Accessed 20 Mar 2018.

  9. Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for squamous cell carcinoma of the oral cavity in young people – a comprehensive literature review. Oral Oncol. 2001;37(5):401–18.

    Article  PubMed  Google Scholar 

  10. Conway DI, Petticrew M, Marlborough H, Berthiller J, Hashibe M, Macpherson LM. Socioeconomic inequalities and oral cancer risk: a systematic review and meta-analysis of case-control studies. Int J Cancer. 2008;122(12):2811–9.

    Article  PubMed  Google Scholar 

  11. Chen AY, Schrag NM, Halpern MT, Ward EM. The impact of health insurance status on stage at diagnosis of oropharyngeal cancer. Cancer. 2007;110:395–402.

    Article  PubMed  Google Scholar 

  12. Ramanathan K, Lakshimi S. Oral carcinoma in Malaysian Indian males. Singap Dent J. 1974;13(2):5–11.

    Google Scholar 

  13. Ayo-Yusuf OA, Lalloo R, Johnson NW. Trends and ethnic disparities in oral and oropharyngeal cancers in South Africa, 1992–2001. South Afr Dent J. 2013;68(4):168–73.

    Google Scholar 

  14. Morse DE, Kerr RA. Disparities in oral and pharyngeal cancer incidence, mortality and survival among black and white Americans. J Am Dent Assoc. 2006;137:203.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Moore RJ, Doherty DA, DO K, Chamberlain RM, Khuri FR. Racial disparity in survival of patients with squamous cell carcinoma of oral cavity and pharynx. Ethn Health. 2001;6:165–77.

    Article  PubMed  Google Scholar 

  16. Warnakulasuriya KA, Johnson NW, Linklater KM, Bell J. Cancer of mouth, pharynx and nasopharynx in Asian and Chinese immigrants residentin Thames regions. Oral Oncol. 1999;35(5):471–5.

    Article  PubMed  Google Scholar 

  17. Gorsky M, Littner MM, Sukman Y, Begleiter A. The prevalence of oral cancer in relation to the ethnic origin of Israeli Jews. Oral Surg Oral Med Oral Pathol. 1994;78(3):408–11.

    Article  PubMed  Google Scholar 

  18. Ariyawardana A, Johnson NW. Trends of lip, oral cavity and oropharyngeal cancers in Australia 1982–2008: overall good news but with rising rates in the oropharynx. BMC Cancer. 2013;13:333.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Domínguez-Gordillo A, Esparza-Gómez G, García-Jiménez B, Cerero-Lapiedra R, Casado-Gómez I, Romero-Lastra P, Warnakulasuriya S. The pattern of lip cancer occurrence over the 1990-2011 period in public hospitals in Madrid, Spain. J Oral Pathol Med. 2016;45(3):202–10.

    Article  PubMed  Google Scholar 

  20. Zini A, Czerninski R, Sgan-Cohen HD. Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites. J Oral Pathol Med. 2010;39(4):299–305.

    Article  PubMed  Google Scholar 

  21. Macfarlane GJ, Boyle P, Scully C. Rising mortality from cancer of the tongue in young Scottish males. Lancet. 1987;2(8564):912.

    Article  PubMed  Google Scholar 

  22. Macfarlane GJ, Boyle P, Scully C. Oral cancer in Scotland: changing incidence and mortality. BMJ. 1992;305(6862):1121–3.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Moller H. Changing incidence of cancer of the tongue, oral cavity, and pharynx in Denmark. J Oral Pathol Med. 1989;18:224–9.

    Article  PubMed  Google Scholar 

  24. Shield KD, Ferlay J, Jemal A, et al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 2017;67(1):51–64.

    Article  PubMed  Google Scholar 

  25. Monteiro LS, Antunes L, Bento MJ, Warnakulasuriya S. Incidence rates and trends of lip, oral and oro-pharyngeal cancers in Portugal. J Oral Pathol Med. 2013;42(4):345–51.

    Article  PubMed  Google Scholar 

  26. Annertz K, Anderson H, Palmér K, Wennerberg J. The increase in incidence of cancer of the tongue in the Nordic countries continues into the twenty-first century. Acta Otolaryngol. 2012;132(5):552–7.

    Article  PubMed  Google Scholar 

  27. Chaturvedi AK, Anderson WF, Lortet-Tieulent J, Curado MP, Ferlay J, Franceschi S, Rosenberg PS, Bray F, Gillison ML. Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. J Clin Oncol. 2013;31(36):4550–9.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Tota JE, Anderson WF, Coffey C, Califano J, Cozen W, Ferris RL, St John M, Cohen EE, Chaturvedi AK. Rising incidence of oral tongue cancer among white men and women in the United States, 1973–2012. Oral Oncol. 2017;67:146–52.

    Article  PubMed  Google Scholar 

  29. Shiboski CH, Shiboski SC, Silverman S Jr. Trends in oral cancer rates in the United States, 1973–1996. Community Dent Oral Epidemiol. 2000;28:249–56.

    Article  PubMed  Google Scholar 

  30. Shiboski CH, Schmidt BL, Jordan RC. Tongue and tonsil carcinoma: increasing trends in the U.S. population ages 20–44 years. Cancer. 2005;103:1843–9.

    Article  PubMed  Google Scholar 

  31. Ligier K, Belot A, Launoy G, Velten M, Bossard N, Iwaz J, et al. Descriptive epidemiology of upper aerodigestive tract cancers in France: incidence over 1980-2005 and projection to 2010. Oral Oncol. 2011 Apr;47(4):302–7.

    Article  PubMed  Google Scholar 

  32. Cancer Statistics in Japan. Center for Cancer Control and Information Services, National Cancer Center, Japan. https://ganjoho.jp/en/professional/statistics/table_download.html.

  33. Ariyawardana A, Warnakulasuriya S. Declining oral cancer rates in Sri Lanka: are we winning the war after being at the top of the cancer league table? Oral Dis. 2011;17(7):636–41.

    Article  PubMed  Google Scholar 

  34. Shridhar K, Rajaraman P, Koyande S, Parikh PM, Chaturvedi P, Dhillon PK, Dikshit RP. Trends in mouth cancer incidence in Mumbai, India (1995–2009): an age-period-cohort analysis. Cancer Epidemiol. 2016;42:66–71.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Gupta PC, Ray CS, Murti PR, Sinha DN. Rising incidence of oral cancer in Ahmedabad city. Indian J Cancer. 2014;51(Suppl 1):S67–72.

    PubMed  Google Scholar 

  36. Pulte D, Brenner H. Changes in survival in head and neck cancers in the late 20th and early 21st century: a period analysis. Oncologist. 2010;15(9):994–1001.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Schwam ZG, Judson BL. Improved prognosis for patients with oral cavity squamous cell carcinoma: analysis of the National Cancer Database 1998-2006. Oral Oncol. 2016;52:45–51.

    Article  PubMed  Google Scholar 

  38. Amit M, Yen TC, Liao CT, Chaturvedi P, Agarwal JP, Kowalski LP, et al. Improvement in survival of patients with oral cavity squamous cell carcinoma: an international collaborative study. Cancer. 2013;119(24):4242–8.

    Article  PubMed  Google Scholar 

  39. Sankaranarayanan R, Ramdas K, Amarasinghe H, Subramanium S, Johnon NW. Chapter 5: Oral cancer: prevention, early detection and treatment. In: Cancer: Disease control priorities, vol. 3. 3rd ed; 2015. p. 85–99. https://doi.org/10.1596/978-1-4648-0349-9_ch5.

    Chapter  Google Scholar 

  40. Yang Y-H, Warnakulasuriya S. Effect of comorbidities on the management and prognosis in patients with oral cancer. Transl Res Oral Oncol. 2016;1:1–8.

    Google Scholar 

  41. Warnakulasuriya S, Mak V, Möller H. Oral cancer survival in young people in South East England. Oral Oncol. 2007;43(10):982–6.

    Article  PubMed  Google Scholar 

  42. Shiboski CH, Schmidt BL, Jordan RC. Racial disparity in stage at diagnosis and survival among adults with oral cancer in the US. Community Dent Oral Epidemiol. 2007;35:233–40.

    Article  PubMed  Google Scholar 

  43. Brown LM, Check DP, Devesa SS. Oropharyngeal cancer incidence trends: diminishing racial disparities. Cancer Causes Control. 2011;22(5):753–63.

    Article  PubMed  Google Scholar 

  44. Curado MP, Johnson NW, Kerr AR, de Silva DRM, Lanfranchi H, Pereira DL, Fonseca FP, Lopes MA, Kowalski LP, Vargas PA. Oral and oropharynx cancer in South America: incidence, mortality trends and gaps in public databases as presented to the Global Oral Cancer Forum. Transl Res Oral Oncol. 2016;1:1–7.

    Google Scholar 

  45. The Brazilian National Cancer Institute. 2018. http://www2.inca.gov.br/wps/wcm/connect/tiposdecancer/site/home/boca.

  46. Moi GP, Silva AMC, Galvão ND, de Castro Meneghim M, Pereira AC. Spatial analysis of the death associated factors due oral cancer in Brazil: an ecological study. BMC Oral Health. 2018;18:14.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Diz P, Meleti M, Diniz-Freitas M, Vescovi P, Warnakulasuriya S, Johnson NW, Kerr AR. Oral and pharyngeal cancer in Europe; Incidence, mortality and trends aspresented to the Global Oral Cancer Forum. Transl Res Oral Oncol. 2017;2:1–16.

    Google Scholar 

  48. Omar K, Farah CS, Johnson NW. Oral and oropharyngeal cancer in the Middle East and North Africa: incidence, mortality, trends, and gaps in public databases as presented to the Global Oral Cancer Forum. Transl Res Oral Oncol. 2017;2:1–9.

    Google Scholar 

  49. Idris AM, Prokopczyk B, Hoffmann D. Toombak: a major risk factor for cancer of the oral cavity in Sudan. Prev Med. 1994;23(6):832–9.

    Article  PubMed  Google Scholar 

  50. Al-Maweri SA, Warnakulasuriya S, Samran A. Khat (Catha edulis) and its oral health effects: an updated review. J Investig Clin Dent. 2018;9(1). https://doi.org/10.1111/jicd.12288.

  51. Quadri MFA, Alharbi F, Bajonaid AMS, et al. Oral squamous cell carcinoma and associated risk factors in Jazan, Saudi Arabia: a hospital based case–control study. Asian Pac J Cancer Prev. 2015;16(10):4335–8.

    Article  PubMed  Google Scholar 

  52. Brown A, Ravichandran K, Warnakulasuriya S. The unequal burden related to the risk of oral cancer in the different regions of the Kingdom of Saudi Arabia. Community Dent Health. 2006;23:101–6.

    PubMed  Google Scholar 

  53. Hille J, Johnson NW. The burden of oral cancer in sub-Saharan Africa: an estimate as presented to the Global Oral Cancer Forum, March 2016. Transl Res Oral Oncol. 2:1–13.

    Article  Google Scholar 

  54. Marimo C, Hille JJ. The burden of oral malignancies in Zimbabwe 1988 to 1997: a population based study. Cent Afr J Med. 2006;52(5–6):51–5.

    PubMed  Google Scholar 

  55. Coelho KR. Challenges of the oral cancer burden in India. J Cancer Epidemiol. 2012;2012:701932. https://doi.org/10.1155/2012/701932. Epub 4 Oct 2012.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Cancer Atlas of India. http://www.canceratlasindia.org/chapter3_1.aspx.

  57. Walvekar RR, Chaukar DA, Deshpande MS, Pai PS, Chaturvedi P, Kakade AC, D’Cruz AK. Prognostic factors for loco-regional failure in early stage (I and II) squamous cell carcinoma of the gingivobuccal complex. Eur Arch Otorhinolaryngol. 2010;267:1135–40.

    Article  PubMed  Google Scholar 

  58. Cheong SC, Vatanasapt P, Yang Y-H, Zain RB, Kerr AR, Johnson NW. Oral cancer in South East Asia: current status and future directions. Transl Res Oral Oncol. 2017;2:1–9.

    Article  Google Scholar 

  59. Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66(2):115–32.

    Article  PubMed  Google Scholar 

  60. Hu YJ, Chen J, Zhong WS, et al. Trend analysis of betel nut-associated oral cancer and health burden in China. Chin J Dent Res. 2017;20(2):69.

    PubMed  Google Scholar 

  61. Pollaers K, Kujan O, Johnson NW, Farah CS. Oral and oropharyngeal cancer in Oceania: incidence, mortality, trends and gaps in public databases as presented to the Global Oral Cancer Forum. Transl Res Oral Oncol. 2017;2:1–8.

    Google Scholar 

  62. Australian Institute of Health and Welfare. Cancer in Australia 2017. Cancer series no. 101. Cat. no. CAN 100. Canberra: Australian Institute of Health and Welfare. http://www.aihw.gov.au/cancer/. Accessed 2 Feb 2017.

  63. Thomas SJ, Bain CJ, Battistutta D, et al. Betel quid not containing tobacco and oral cancer: a report on a case-control study in Papua New Guinea and a meta-analysis of current evidence. Int J Cancer. 2007;120:1318–23.

    Article  PubMed  Google Scholar 

  64. Schantz SP, Yu GP. Head and neck cancer incidence trends in young Americans, 1973 to 1997, with a special analysis for tongue cancer. Arch Otolaryngol Head Neck Surg. 2002;128(3):268e74.

    Article  Google Scholar 

  65. Patel SC, Carpenter WR, Tyree S, Couch ME, Weissler M, Hackman T, et al. Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years. J Clin Oncol. 2011;29(11):1488e94.

    Article  Google Scholar 

  66. Forte T, Niu J, Lockwood GA, Bryant HE. Incidence trends in head and neck cancers and human papillomavirus (HPV)-associated oropharyngeal cancer in Canada, 1992–2009. Cancer Causes Control. 2012;23(8):1343–8.

    Article  Google Scholar 

  67. Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for oral cancer in newly diagnosed patients aged 45 years and younger: a case-control study in Southern England. J Oral Pathol Med. 2004;33(9):525–32.

    Article  PubMed  Google Scholar 

  68. Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for squamous cell carcinoma of the oral cavity in young people - a comprehensive literature review. Oral Oncol. 2001;37(5):401–18.

    Article  PubMed  Google Scholar 

  69. Gilhodes J, Belot A, Bouvier AM, Remontet L, Delafosse P, Ligier K, Rogel A. Incidence of major smoking-related cancers: trends among adults aged 20-44 in France from 1982 to 2012. Cancer Epidemiol. 2015;39(5):707–13.

    Article  PubMed  Google Scholar 

  70. Hussein AA, Helder MN, de Visscher JG, Leemans CR, Braakhuis BJ, de Vet HCW, Forouzanfar T. Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: a systematic review. Eur J Cancer. 2017;82:115–27.

    Article  PubMed  Google Scholar 

  71. Doobaree IU, Landis SH, Linklater KM, El-Hariry I, Moller H, Tyczynski J. Head and neck cancer in South East England between1995 to 1999 and 2000 to 2004: an estimation of incidence and distribution by site, stage and histological type. Oral Oncol. 2009;45(9):809e14.

    Article  Google Scholar 

  72. Mehta V, Yu GP, Schantz SP. Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics. Laryngoscope. 2010;120(11):2203e12.

    Article  Google Scholar 

  73. Braakhuis BJ, Visser O, Leemans CR. Oral and oropharyngeal cancer in the Netherlands between1989 and 2006: increasing incidence, but not in young adults. Oral Oncol. 2009;45:e85–9.

    Article  PubMed  Google Scholar 

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Warnakulasuriya, S., Greenspan, J.S. (2020). Epidemiology of Oral and Oropharyngeal Cancers. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_2

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