Skip to main content

Brain

  • Chapter
  • First Online:
Pediatric Ultrasound

Abstract

Cranial ultrasound is a valuable diagnostic tool with distinct advantages compared to alternative imaging modalities such as computed tomography (CT) and magnetic resonance (MR) imaging, particularly in the young child, including easy accessibility, relatively low cost, no radiation, and a short examination time. In this chapter, up-to-date imaging techniques, development and anatomy, and common disorders encountered in clinical practice are discussed, as well as rare and challenging but important diagnoses in the pediatric population. Inherent limitations of cranial ultrasound as well as common pitfalls are reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

3D:

Three-dimensional

AHW:

Anterior horn width

AIS:

Acute ischemic stroke

AVF:

Arteriovenous fistula

AVM:

Arteriovenous malformation

BEH:

Benign external hydrocephalus

CM:

Capillary malformation

CMV:

Cytomegalovirus

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

CT:

Computed tomography

DVA:

Developmental venous anomaly

ECMO:

Extracorporeal membrane oxygenation

Hib:

Haemophilus influenza type b

HIE:

Hypoxic ischemic encephalopathy

HII:

Hypoxic ischemic injury

HIV:

Human immunodeficiency virus

HSV:

Herpes simplex virus

IHW:

Interhemispheric width

ISSVA:

International Society for the Study of Vascular Anomalies

IVH:

Intraventricular hemorrhage

LM:

Lymphatic malformation

MCA:

Middle cerebral artery

MR:

Magnetic resonance

NAIS:

Neonatal arterial ischemic stroke

PIVH:

Periventricular/intraventricular hemorrhage

PVHI:

Periventricular hemorrhagic infarction

PVL:

Periventricular leukomalacia

SIDS:

Sudden infant death syndrome

STOP:

Stroke Prevention in Sickle Cell Anemia

TAMMX:

Time-averaged mean of the maximum velocity

TCD:

Transcranial Doppler

TOD:

Thalamo-occipital distance

VI:

Ventricular index

VM:

Venous malformation

VOGM:

Vein of Galen Malformation

References

  1. D’Antoni AV, Donaldson OI, Schmidt C, Macchi V, De Caro R, Oskouian RJ, et al. A comprehensive review of the anterior fontanelle: embryology, anatomy, and clinical considerations. Childs Nerv Syst. 2017;33(6):909–14.

    Article  PubMed  Google Scholar 

  2. Lipsett BJ, Steanson K. Anatomy, head and neck, fontanelles. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2019. cited 2020 Jan 6.

    Google Scholar 

  3. Beasley, Melanie. “Age of Closure of Fontanelles/Sutures”. The Center for Academic Research and Training in Anthropogeny (CARTA). Retrieved 02 December 2020.

    Google Scholar 

  4. Veyrac C, Couture A, Saguintaah M, Baud C. Brain ultrasonography in the premature infant. Pediatr Radiol. 2006;36(7):626–35.

    Article  PubMed  Google Scholar 

  5. Yikilmaz A, Taylor GA. Cranial sonography in term and near-term infants. Pediatr Radiol. 2008;38(6):605–16.

    Google Scholar 

  6. Kurian J, Sotardi S, Liszewski MC, Gomes WA, Hoffman T, Taragin BH. Three-dimensional ultrasound of the neonatal brain: technical approach and spectrum of disease. Pediatr Radiol. 2017;47(5):613–27.

    Article  PubMed  Google Scholar 

  7. Elshazzly M, Caban O. Embryology, central nervous system. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2019. [cited 2020 Jan 6].

    Google Scholar 

  8. Yousem DM, Nadgir R. Neuroradiology - the requisites in radiology. 4th ed. Philadelphia: Elsevier; 2017. Chapter 9, Congenital disorders of the brain and spine; p.279–280.

    Google Scholar 

  9. Barkovich AJ, Guerrini R, Kuzniecky RI, Jackson GD, Dobyns WB. A developmental and genetic classification for malformations of cortical development: update 2012. Brain. 2012;135(Pt 5):1348–69.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Daneman A, Epelman M, Blaser S, Jarrin JR. Imaging of the brain in full-term neonates: does sonography still play a role? Pediatr Radiol. 2006;36(7):636–46.

    Article  PubMed  Google Scholar 

  11. Friede RL. Developmental neuropathology. 2nd ed. Berlin, Heidelberg: Springer-Verlag; 1989. Chapter 1, Gross and microscopic development of the central nervous system; p. 2–20.

    Google Scholar 

  12. Rutherford MA, Pennock JM, Counsell SJ, Mercuri E, Cowan FM, Dubowitz LM, et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics. 1998;102(2 Pt 1):323–8.

    Article  CAS  PubMed  Google Scholar 

  13. Van Wezel-Meijler G, Leijser LM, Wiggers-de Bruïne FT, Steggerda SJ, van der Grond J, Walther FJ. Diffuse hyperechogenicity of basal ganglia and thalami in preterm neonates: a physiologic finding? Radiology. 2011;258(3):944–50.

    Article  PubMed  Google Scholar 

  14. Lowe LH, Bailey Z. State-of-the-art cranial sonography: part 2, pitfalls and variants. AJR Am J Roentgenol. 2011;196(5):1034–9.

    Article  PubMed  Google Scholar 

  15. Ichihashi K, Iino M, Eguchi Y, Uchida A, Honma Y, Momoi M. Difference between left and right lateral ventricular sizes in neonates. Early Hum Dev. 2002;68(1):55–64.

    Article  PubMed  Google Scholar 

  16. Kiroğlu Y, Karabulut N, Oncel C, Yagci B, Sabir N, Ozdemir B. Cerebral lateral ventricular asymmetry on CT: how much asymmetry is representing pathology? Surg Radiol Anat. 2008;30(3):249–55.

    Article  PubMed  Google Scholar 

  17. Pal B, Preston P, Morgan M, Rushton D, Durbin G. Frontal horn thin walled cysts in preterm neonates are benign. Arch Dis Child Fetal Neonatal Ed. 2001;85(3):F187–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Bosemani T, Orman G, Boltshauser E, Tekes A, Huisman TA, Poretti A. Congenital abnormalities of the posterior fossa. Radiographics. 2015;35(1):200–20.

    Google Scholar 

  19. Fakhri A, Shah MN, Goyal MS. Advanced imaging of Chiari 1 malformations. Neurosurg Clin N Am. 2015;26(4):519–26.

    Article  PubMed  Google Scholar 

  20. Elster AD, Chen MY. Chiari I malformations: clinical and radiologic reappraisal. Radiology. 1992;183(2):347–53.

    Article  CAS  PubMed  Google Scholar 

  21. Menick BJ. Phase-contrast magnetic resonance imaging of cerebrospinal fluid flow in the evaluation of patients with Chiari I malformation. Neurosurg Focus. 2001;11(1):E5.

    Article  CAS  PubMed  Google Scholar 

  22. Poretti A, Boltshauser E, Huisman TA. Chiari malformations and syringohydromyelia in children. Semin Ultrasound CT MR. 2016;37(2):129–42.

    Google Scholar 

  23. Morishima A, Aranoff GS. Syndrome of septo-optic-pituitary dysplasia: the clinical spectrum. Brain Dev. 1986;8(3):233–9.

    Google Scholar 

  24. Barkovitch AJ, Raybaud C. Congenital malformations of the brain and skull. In: Barkovitch AJ, Raybaud C, editors. Pediatric neuroimaging. 6th ed. Philadelphia. Wolters Kluwer; 2019.

    Google Scholar 

  25. Schell-Apacik CC, Wagner K, Bihler M, Ertl-Wagner B, Heinrich U, Klopocki E, et al. Agenesis and dysgenesis of the corpus callosum: clinical, genetic and neuroimaging findings in a series of 41 patients. Am J Med Genet A. 2008;146A(19):2501–11.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Uchino A, Hasuo K, Matsumoto S, Masuda K. Solitary choroid plexus lipomas: CT and MR appearance. AJNR Am J Neuroradiol. 1993;14(1):116–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Poretti A, Boltshauser E, Huisman TA. Cerebellar and brainstem malformations. Neuroimaging Clin N Am. 2016;26(3):341–57.

    Article  PubMed  Google Scholar 

  28. Estroff JA, Scott MR, Benacerraf BR. Dandy-Walker variant: prenatal sonographic features and clinical outcome. Radiology. 1992;185(3):755–8.

    Article  CAS  PubMed  Google Scholar 

  29. Stambolliu E, Ioakeim-Ioannidou M, Kontokostas K, Dakoutrou M, Kousoulis AA. The most common comorbidities in Dandy-Walker syndrome patients: a systematic review of case reports. J Child Neurol. 2017;32(10):886–902.

    Article  PubMed  Google Scholar 

  30. Williams F, Griffiths PD. In utero MR imaging in fetuses at high risk of lissencephaly. BJR. 2017;90(1072):20160902.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Squier W, Jansen A. Polymicrogyria: pathology, fetal origins and mechanisms. Acta Neuropathol Commun. 2014;2:80.

    Google Scholar 

  32. Barkovich AJ, Kjos BO. Schizencephaly: correlation of clinical findings with MR characteristics. AJNR Am J Neuroradiol. 1992;13(1):​85–94.

    CAS  PubMed  PubMed Central  Google Scholar 

  33. Beltempo M, Wintermark P, Lemyre B, Shalish W, Martel-Bucci A, Narvey M, et al. Predictors of severe neurologic injury on ultrasound scan of the head and risk factor-based screening for infants born preterm. J Pediatr. 2019;214:27–33.e3.

    Google Scholar 

  34. Papile L-A, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92(4):529–34.

    Article  CAS  PubMed  Google Scholar 

  35. Prabhu SP, Andronikou S, Vargas SO, Robertson RL. Brain. In: Lee EY, editor. Pediatric radiology: practical imaging evaluation of infants and children. 1st ed. Philadelphia. Lippincott Williams & Wilkins; 2017.

    Google Scholar 

  36. Limperopoulos C, du Plessis AJ, Volpe JJ. Cerebellar hemorrhage. In: Volpe JJ, Inder TE, Darras BT, de Vries LS, du Plessis AJ, Neil JJ, Perlman JM, editors.Volpe’s neurology of the newborn. 6th ed. Philadelphia. Elsevier; 2018.

    Google Scholar 

  37. Rocchi G, Caroli E, Raco A, Salvati M, Delfini R. Traumatic epidural hematoma in children. J Child Neurol. 2005;20(7):569–71.

    Article  PubMed  Google Scholar 

  38. Hobbs C. Subdural haematoma and effusion in infancy: an epidemiological study. Arch Dis Childhood. 2005;90(9):952–5.

    Article  CAS  Google Scholar 

  39. Reeder JD, Kaude JV, Setzer ES. Choroid plexus hemorrhage in premature neonates: recognition by sonography. AJNR Am J Neuroradiol. 1982;3(6):619–22.

    CAS  PubMed  PubMed Central  Google Scholar 

  40. DiPietro MA, Brody BA, Teele RL. Peritrigonal echogenic “blush” on cranial sonography: pathologic correlates. AJR Am J Roentgenol. 1986;146(5):1067–72.

    Article  CAS  PubMed  Google Scholar 

  41. Takashima S, Tanaka K. Development of cerebrovascular architecture and its relationship to periventricular leukomalacia. Arch Neurol. 1978;35(1):11–6.

    Article  CAS  PubMed  Google Scholar 

  42. Epelman M, Daneman A, Chauvin N, Hirsch W. Head ultrasound and MR imaging in the evaluation of neonatal encephalopathy: competitive or complementary imaging studies? Magn Reson Imaging Clin N Am. 2012;20(1):93–115.

    Article  PubMed  Google Scholar 

  43. Dinan D, Daneman A, Guimaraes CV, Chauvin NA, Victoria T, Epelman M. Easily overlooked sonographic findings in the evaluation of neonatal encephalopathy: lessons learned from magnetic resonance imaging. Semin Ultrasound CT MR. 2014;35(6):627–51.

    Article  PubMed  Google Scholar 

  44. Jones BP, Ganesan V, Saunders DE. Chong WK. Imaging in childhood arterial ischaemic stroke. Neuroradiology. 2010;52(6):577–89.

    Google Scholar 

  45. Kirton A, Armstrong-Wells J, Chang T, Deveber G, Rivkin MJ, Hernandez M, et al. Symptomatic neonatal arterial ischemic stroke: the International Pediatric Stroke Study. Pediatrics. 2011;128(6):e1402–10.

    Article  PubMed  Google Scholar 

  46. Ibrahim SH. Cerebral venous sinus thrombosis in neonates. J Pak Med Assoc. 2006;56(11):535–7.

    PubMed  Google Scholar 

  47. Dion J, Bachmeyer C, Favrole P, Marro B, Lionnet F. Moya-moya in an adult with sickle cell anemia. Presse Med. 2011;40(4 Pt 1):450–1.

    Article  PubMed  Google Scholar 

  48. Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998;91(1):288–94.

    CAS  PubMed  Google Scholar 

  49. Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339(1):5–11.

    Article  CAS  PubMed  Google Scholar 

  50. Adams RJ, Brambilla D. Optimizing primary stroke prevention in sickle cell anemia (STOP 2) trial investigators. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N Engl J Med. 2005;353(26):2769–78.

    Article  CAS  PubMed  Google Scholar 

  51. Adams RJ, McKie VC, Carl EM, Nichols FT, Perry R, Brock K, et al. Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler. Ann Neurol. 1997;42(5):699–704.

    Article  CAS  PubMed  Google Scholar 

  52. Venketasubramanian N, Prohovnik I, Hurlet A, Mohr JP, Piomelli S. Middle cerebral artery velocity changes during transfusion in sickle cell anemia. Stroke. 1994;25(11):2153–8.

    Article  CAS  PubMed  Google Scholar 

  53. Russell MO, Goldberg HI, Hodson A, Kim HC, Halus J, Reivich M, et al. Effect of transfusion therapy on arteriographic abnormalities and on recurrence of stroke in sickle cell disease. Blood. 1984;63(1):162–9.

    Article  CAS  PubMed  Google Scholar 

  54. Stegmann BJ, Carey JC. TORCH infections. Toxoplasmosis, Other (syphilis, varicella-zoster, parvovirus B19), Rubella, Cytomegalovirus (CMV), and Herpes infections. Curr Womens Health Rep. 2002;2(4):253–8.

    Google Scholar 

  55. Koeller KK, Shih RY. Viral and prion infections of the central nervous system: radiologic-pathologic correlation: from the radiologic pathology archives. Radiographics. 2017;37(1):199–233.

    Article  PubMed  Google Scholar 

  56. Marsico C, Kimberlin DW. Congenital Cytomegalovirus infection: advances and challenges in diagnosis, prevention and treatment. Ital J Pediatr. 2017;43(1):38.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Sisman J, Chalak L, Heyne R, Pritchard M, Weakley D, Brown LS, et al. Lenticulostriate vasculopathy in preterm infants: a new classification, clinical associations and neurodevelopmental outcome. J Perinatol. 2018;38(10):1370–8.

    Article  CAS  PubMed  Google Scholar 

  58. Kohl S. Neonatal herpes simplex virus infection. Clin Perinatol. 1997;24(1):129–50.

    Article  CAS  PubMed  Google Scholar 

  59. Vossough A, Zimmerman RA, Bilaniuk LT, Schwartz EM. Imaging findings of neonatal herpes simplex virus type 2 encephalitis. Neuroradiology. 2008;50(4):355–66.

    Article  PubMed  Google Scholar 

  60. De Fatima Viana Vasco Aragao M, de Lima Petribu NC, van der Linden V, Valenca MM, de Brito CAA, Parizel PM. Updated imaging findings in congenital Zika syndrome: a disease story that is still being written. Top Magn Reson Imaging. 2019;28(1):1–14.

    Article  PubMed  Google Scholar 

  61. Stoll BJ, Hansen NI, Sánchez PJ, Faix RG, Poindexter BB, Van Meurs KP, et al. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics. 2011;127(5):817–26.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Chaves CEV, Brandão MLL, Lacerda MLGG, Rocha CABC, Leone de Oliveira SM, do V, Parpinelli TC, et al. Fatal Cronobacter sakazakii sequence type 494 Meningitis in a Newborn, Brazil. Emerg Infect Dis. 2018;24(10):1948–50.

    Article  PubMed  PubMed Central  Google Scholar 

  63. Gupta N, Grover H, Bansal I, Hooda K, Sapire JM, Anand R, et al. Neonatal cranial sonography: ultrasound findings in neonatal meningitis-a pictorial review. Quant Imaging Med Surg. 2017;7(1):123–31.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Isaacs H. II. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol. 2002;27(5):333–42.

    Article  PubMed  Google Scholar 

  65. Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C, Barnholtz-Sloan JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011-2015. Neuro-Oncology. 2018;20(suppl_4):iv1–86.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Kramer K. Rare primary central nervous system tumors encountered in pediatrics. J Child Neurol. 2016;31(12):1394–8.

    Google Scholar 

  67. Morshed RA, Lau D, Sun PP, Ostling LR. Spinal drop metastasis from a benign fourth ventricular choroid plexus papilloma in a pediatric patient: case report. J Neurosurgery Pediatr. 2017;20(5):471–9.

    Article  Google Scholar 

  68. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982;69(3):412–22.

    Article  CAS  PubMed  Google Scholar 

  69. Lee JW, Chung HY. Vascular anomalies of the head and neck: current overview. Arch Craniofac Surg. 2018;19(4):243–7.

    Article  PubMed  PubMed Central  Google Scholar 

  70. Gupta AK, Varma DR. Vein of Galen malformations: review. Neurol India. 2004;52(1):43–53.

    Article  CAS  PubMed  Google Scholar 

  71. Levene MI. Measurement of the growth of the lateral ventricles in preterm infants with real-time ultrasound. Arch Dis Child. 1981;56(12):900–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Davies MW, Swaminathan M, Chuang SL, Betheras FR. Reference ranges for the linear dimensions of the intracranial ventricles in preterm neonates. Arch Dis Child Fetal Neonatal Ed. 2000;82(3):​F218–23.

    Google Scholar 

  73. Brouwer MJ, de Vries LS, Groenendaal F, Koopman C, Pistorius LR, Mulder EJH, et al. New reference values for the neonatal cerebral ventricles. Radiology. 2012;262(1):224–33.

    Article  PubMed  Google Scholar 

  74. Brann BS, Qualls C, Wells L, Papile L. Asymmetric growth of the lateral cerebral ventricle in infants with posthemorrhagic ventricular dilation. J Pediatr. 1991;118(1):108–12.

    Article  PubMed  Google Scholar 

  75. Grant EG, Borts FT, Schellinger D, McCullough DC, Sivasubramanian KN, Smith Y. Real-time ultrasonography of neonatal intraventricular hemorrhage and comparison with computed tomography. Radiology. 1981;139(3):687–91.

    Article  CAS  PubMed  Google Scholar 

  76. Robinson S. Neonatal posthemorrhagic hydrocephalus from prematurity: pathophysiology and current treatment concepts. J Neurosurg Pediatr. 2012;9(3):242–58.

    Article  PubMed  Google Scholar 

  77. Yew AY, Maher CO, Muraszko KM, Garton HJL. Long-term health status in benign external hydrocephalus. Pediatr Neurosurg. 2011;47(1):1–6.

    Article  PubMed  Google Scholar 

  78. Zahl SM, Egge A, Helseth E, Wester K. Benign external hydrocephalus: a review, with emphasis on management. Neurosurg Rev. 2011;34(4):417–32.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Amodio J, Spektor V, Pramanik B, Rivera R, Pinkney L, Fefferman N. Spontaneous development of bilateral subdural hematomas in an infant with benign infantile hydrocephalus: color Doppler assessment of vessels traversing extra-axial spaces. Pediatr Radiol. 2005;35(11):1113–7.

    Article  PubMed  Google Scholar 

  80. Yoon SH, Park S-H. A study of 77 cases of surgically excised scalp and skull masses in pediatric patients. Childs Nerv Syst. 2008;24(4):459–65.

    Article  PubMed  Google Scholar 

  81. Hayden Gephart MG, Colglazier E, Paulk KL, Vogel H, Guzman R, Edwards MSB. Primary pediatric skull tumors. Pediatr Neurosurg. 2011;47(3):198–203.

    Article  PubMed  Google Scholar 

  82. Gibson SE, Prayson RA. Primary skull lesions in the pediatric population: a 25-year experience. Arch Pathol Lab Med. 2007;131(5):761–6.

    Article  PubMed  Google Scholar 

  83. Smirniotopoulos JG, Chiechi MV. Teratomas, dermoids, and epidermoids of the head and neck. Radiographics. 1995;15(6):1437–55.

    Article  CAS  PubMed  Google Scholar 

  84. Martínez-Lage JF, Capel A, Costa TR, Perez-Espejo MA, Poza M. The child with a mass on its head: diagnostic and surgical strategies. Childs Nerv Syst. 1992;8(5):247–52.

    Article  PubMed  Google Scholar 

  85. Jose-Popoola O, Lin HW, Silvera VM, Teot LA, Madsen JR, Meara JG, et al. Nasal glioma: prenatal diagnosis and multidisciplinary surgical approach. Skull Base Rep. 2011;1(2):83–8.

    Article  Google Scholar 

  86. Sharman AM, Kirmi O, Anslow P. Imaging of the skin, subcutis, and galea aponeurotica. Semin Ultrasound CT MR. 2009;30(6):452–64.

    Article  PubMed  Google Scholar 

  87. Wisser M, Rothschild MA, Schmolling JC, Banaschak S. Caput succedaneum and facial petechiae-birth-associated injuries in healthy newborns under forensic aspects. Int J Legal Med. 2012;126(3):385–90.

    Article  PubMed  Google Scholar 

  88. Chang H-Y, Peng C-C, Kao H-A, Hsu C-H, Hung H-Y, Chang J-H. Neonatal subgaleal hemorrhage: clinical presentation, treatment, and predictors of poor prognosis. Pediatr Int. 2007;49(6):903–7.

    Article  PubMed  Google Scholar 

  89. Currarino G. Neonatal subperiosteal cephalohematoma crossing a synostosed sagittal suture. Pediatr Radiol. 2007;37(12):1283–5.

    Article  PubMed  Google Scholar 

  90. Krowchuk DP, Frieden IJ, Mancini AJ, Darrow DH, Blei F, Greene AK, et al. Clinical practice guideline for the management of infantile hemangiomas. Pediatrics. 2019;143(1):e20183475.

    Article  PubMed  Google Scholar 

  91. Bigot JL, Iacona C, Lepreux A, Dhellemmes P, Motte J, Gomes H. Sinus pericranii: advantages of MR imaging. Pediatr Radiol. 2000;30(10):710–2.

    Article  CAS  PubMed  Google Scholar 

  92. Gandolfo C, Krings T, Alvarez H, Ozanne A, Schaaf M, Baccin CE, et al. Sinus pericranii: diagnostic and therapeutic considerations in 15 patients. Neuroradiology. 2007;49(6):505–14.

    Article  PubMed  Google Scholar 

  93. Rozovsky K, Udjus K, Wilson N, Barrowman NJ, Simanovsky N, Miller E. Cranial ultrasound as a first-line imaging examination for craniosynostosis. Pediatrics. 2016;137(2):e20152230.

    Google Scholar 

  94. Muenke M, Gripp KW, McDonald-McGinn DM, Gaudenz K, Whitaker LA, Bartlett SP, et al. A unique point mutation in the fibroblast growth factor receptor 3 gene (FGFR3) defines a new craniosynostosis syndrome. Am J Hum Genet. 1997;60(3):555–64.

    CAS  PubMed  PubMed Central  Google Scholar 

  95. Boulet SL, Rasmussen SA, Honein MA. A population-based study of craniosynostosis in metropolitan Atlanta, 1989-2003. Am J Med Genet A. 2008;146A(8):984–91.

    Article  PubMed  Google Scholar 

  96. Reardon. Craniosynostosis. Diagnosis, evaluation and management. J Med Genet. 2000;37(9):727.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Positional plagiocephaly and sleep positioning. An update to the joint statement on sudden infant death syndrome. Paediatr Child Health. 2001;6(10):788–9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Grace S. Phillips .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kim, H.H.R., Kim, W.G., Lee, E.Y., Phillips, G.S. (2021). Brain. In: Paltiel, H.J., Lee, E.Y. (eds) Pediatric Ultrasound. Springer, Cham. https://doi.org/10.1007/978-3-030-56802-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-56802-3_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56801-6

  • Online ISBN: 978-3-030-56802-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics