Abstract
Peumus boldus is a tree that grows in relatively humid habitats, from the semiarid to the temperate forest regions in Chile. Its leaves are exported in large amounts and are widely used to prepare a digestive tea. Historically they were employed for headaches, rheumatism, and severe but not clearly identified conditions characterized by fever, edema, catarrh, and also sexually transmitted diseases. The most characteristic constituents are a mainly terpenoidal essential oil and a number of isoquinoline and aporphine alkaloids. Remarkably, it is generally not the major alkaloidal component of the leaves, boldine that continues to be the subject of pharmacological investigations: some of these seem to support the traditional uses of boldo leaves.
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References
Asencio M, Delaquerrière B, Cassels BK, Speisky H, Comoy E, Protais P (1999) Biochemical and behavioral effects of boldine and glaucine on dopamine systems. Pharmacol Biochem Behav 62:7–13. https://doi.org/10.1016/S0091-3057(98)00096-3
Backhouse N, Delporte C, Cassels BK, Valenzuela A, Speisky H (1994) Anti-inflammatory and antipyretic effects of boldine. Agents Actions 42:114–117
Bannach R, Valenzuela A, Cassels BK, Núñez-Vergara LJ, Speisky H (1996) Cytoprotective and antioxidant effects of boldine on tert-butyl-hydroperoxide-induced damage to isolated hepatocytes. Cell Biol Toxicol 12:89–100
Benedetti S, Barros S (eds) (2018) Boldo (Peumus boldus Mol.). Avances en la investigación para el desarrollo de modelos productivos sustentables. Ed. INFOR, Santiago, Chile, 144 pp
Betancur RJ, Gonzalo Silva AG, Rodríguez JM, Fischer GS, Zapata SM (2010) Insecticidal activity of Peumus boldus Molina essential oil against Sitophilus zeamais Motschulsky. Chil J Agric Res 70(3):399–407
Bourgoin E, Verne C (1872) Sur l’existence d’un alcali organique dans le boldo. J Pharm Chim 16:191–193
Bruneton J, Hatton C, Bruneton A (2008) Pharmacognosy, phytochemistry, medicinal plants. Ed. Intercept/Lavoisier, Andover, USA, p 1019
Cassels BK, Asencio M, Conget P, Speisky H, Videla LA, Lissi EA (1995) Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. Pharmacol Res 31:103–107
Cassels BK, Fuentes-Barros G, Castro-Saavedra S (2019) Boldo, its secondary metabolites and their derivatives. Curr Trad Med 5:31–65
Chile Aduana (2019) https://www.aduana.cl/aduana/site/edic/base/port/estadisticas.html. (Last access, August 2019)
Cordero-Pérez P, Torres-González L, Aguirre-Garza M, Camara-Lemarroy C, Guzmán-de la Garza F, Alarcón-Galván G, Zapata-Chavira H, Sotelo-Gallegos M, Torres-Esquivel CN, Sánchez-Fresno E, Cantú-Sepúlveda D, González-Saldívar G, Bernal-Ramírez J, Muñoz-Espinosa LE (2013) Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats. Pharm Res 5(3):150–156
Dillehay TD (1984) A late ice-age settlement in Southern Chile. Sci American 251(4):100–109
Donoso S, Peña-Rojas K, Durán S, Pacheco C, Galdames E, Espinoza C (2015) Influence of thinning over growth, water potential and photosynthetic response of Peumus boldus: guidelines for their silvicultural management proposal. Bosque (Valdivia) 36(3):457–466
EMA, Committee on Herbal Medicinal Products (2019) Boldi folium (PDF). https://www.ema.europa.eu/en/search/search?search_api_views_fulltext=boldo (last access, December 2019)
Evans WC (2009) Trease & Evans’s pharmacognosy, 16th edn. Ed. WB Saunders, London, UK, p 616
Falé PL, Amaral F, Madeira PJA, Silva MS, Florêncio MH, Frazão FN, Serralheiro MLM (2012) Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. Food Chem Toxicol 50:2656–2662
Farmacopea Argentina, VII Edición (2013) ANMAT, Ministerio de Salud, Buenos Aires, Argentina, p 445
Farmacopea Chilena, IV Edición (2017) Universidad de Valparaíso, Valparaíso, Chile
Farmacopeia Brasileira, VI Edição (2019) ANVISA, Vol II, PM021-00
Frézier AF (1716 or 2nd ed. 1732?) cited by Molina (1782, p 168) Relation du voyage de la mer du Sud, aux côtes du Chili, du Pérou et de Brésil, fait pendant les années 1712, 1713, et 1714. vol I, pp 137–139
Fuentes-Barros G, Castro-Saavedra S, Liberona L, Acevedo-Fuentes W, Tirapegui C, Cassels BK (2018) Variation of the alkaloid content of Peumus boldus (boldo). Fitoterapia 127:179–185
Gay C (1849) Historia Física y Política de Chile, vol 5. Museo de Historia Natural, Santiago, Chile, pp 351–353
Gotteland M, Espinoza J, Cassels BK, Speisky H (1995) Efecto de un extracto seco de boldo sobre el tránsito intestinal oro-cecal en voluntarios sanos. Rev Méd Chile 123:955–960
Grassmann J, Elstner EF (2003) In: Caballero B, Finglas P, Toldra F (eds) Encyclopedia of food sciences and nutrition, 2nd edn. Ed. Academic, San Diego, USA, pp 2177–2184
Heinrich M, Barnes J, Prieto-García JM, Gibbons S, Williamson EM (2018) Fundamentals of pharmacognosy and phytotherapy. Ed. Churchill Livingstone, London, UK, p 360
Kreitmair H (1952) Pharmakologische Wirkung des Alkaloids aus Peumus boldus Molina. Pharmazie 7:507–511
Krug H, Borkowski B (1965) Flavonoidverbindungen in den Blättern von Peumus boldus Molina. Naturwiss 52(7):161
Lanhers MC, Joyeux M, Soulimani R, Fleurentin J, Sayag M, Mortier F, Younos C, Pelt J (1991) Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus. Planta Med 57:110–115
Looser G (1935) ¿Cuál es el verdadero nombre botánico del peumo y del boldo? Rev Chil Hist Nat 39(1):203–211
Madrero Y, Elorriaga M, Martínez S, Noguera MA, Cassels BK, D’Ocon P, Ivorra MD (1996) A possible structural determinant of selectivity of boldine and derivatives for the α1A-adrenoceptor subtype. Brit J Pharmacol 119:1563–1568
Molina JI (1782) Saggio sulla storia naturale del Chili. Ed. Stamperia de S. Tomasso d'Aquino. Bologna, Italy, 568 pp
Murillo A (1889) Plantes médicinales du Chili. Exposition Universelle de Paris 1889, Section Chilienne, Paris. France, pp 142–149
Neger WF (1901) Ueber Folia Boldi. Pharmazeut Zentralh 42(31):461–464
Neger WF (1902) Sobre la hoja del boldo. Rev Chil Hist Nat 6(1):56–57
Pizarro S (1989) Estudio fitosociológico estadístico de los bosques de boldo de la cuenca de Río Bueno (Chile). Thesis, Universidad Austral, Valdivia, Chile, 80 pp
Puga Borne F, Miranda JB (1905) Farmacopea Chilena. Ed. Imprenta Barcelona, Santiago, Chile
Qiu X, Shi L, Zhuang H et al (2017) Cerebrovascular protective effect of boldine against neural apoptosis via inhibition of mitochondrial Bax translocation and cytochrome C release. Med Sci Monit 23:4106–4116
Quezada N, Asencio M, del Valle JM, Aguilera JM, Gómez B (2004) Antioxidant activity of crude extract, alkaloid fraction, and flavonoid fraction from boldo (Peumus boldus Molina) leaves. J Food Sci 69(5):C371–C376
Renner SS, Strijk JS, Strasberg D, Thébaud C (2010) Biogeography of the Monimiaceae (Laurales): a role for East Gondwana and long-distance dispersal, but not West Gondwana. J Biogeogr 37(7):1227–1238
Ruiz H, Pavón J (1798) Systema Vegetabilium Florae Peruvianae et Chilensis. Ed. De Sancha G, Madrid, Spain, pp 267–269
Schmeda-Hirschmann G, Rodríguez JA, Theoduloz C, Astudillo SL, Feresin GE, Tapia A (2003) Free-radical scavengers and antioxidants from Peumus boldus Mol. (“boldo”). Free Rad Res 37(4):447–452
Speisky H, Cassels BK, Lissi EA, Videla LA (1991) Antioxidant properties of the alkaloid boldine in systems undergoing lipid peroxidation and enzyme inactivation. Biochem Pharmacol 41:1575–1582
Urzúa A, Santander R, Echeverría J, Villalobos C, Palacios SM, Rossi Y (2010) Insecticidal properties of Peumus boldus Mol. essential oil on the house fly, Musca domestica L. BLACPMA 9(6):465–469
USP (2013) Peumus boldus leaf. Herbal Medicines Compendium https://hmc.usp.org/monographs/peumus-boldus-leaf-0-1. (Last access, December 2019)
Verne C (1874) Étude sur le boldo. Thesis. École Supérieure de Pharmacie, Paris, France, 52 pp
Vogel H, González B, Razmilic I (2011) Boldo (Peumus boldus) cultivated under different light conditions, soil humidity and plantation density. Ind Crop Prod 34:1310–1312
Walstab J, Wohlfarth C, Hovius R, Schmitteckert S, Röth R, Lasitschka F, Wink M, Bönisch H, Niesler B (2014) Natural compounds boldine and menthol are antagonists of human 5-HT3 receptors: implications for treating gastrointestinal disorders. Neurogastroenterol Motil 26(6):810–820
Wichtl M (2004) Boldi folium. In: Herbal drugs and phytopharmaceuticals, 3rd edn. (English). Ed. Medpharm Scientific Publishers, Stuttgart, and CRC Press, Boca Raton, USA, pp 91–93
Yi C, Ezan P, Fernández P et al (2017) Inhibition of glial hemichannels by boldine treatment reduces neural suffering in a murine model of Alzheimer’s disease. Glia 65:1607–1625
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Cassels, B.K. (2021). Peumus boldus Mol.. In: Máthé, Á., Bandoni, A. (eds) Medicinal and Aromatic Plants of South America Vol. 2. Medicinal and Aromatic Plants of the World, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-030-62818-5_33
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