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Acute Fatty Liver of Pregnancy

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Obstetric Catastrophes

Abstract

Acute fatty liver of pregnancy (AFLP) is a rare, but potentially fatal, condition that is characterized by hepatic failure typically in the third trimester associated with multiorgan involvement resulting in a number of clinical and laboratory abnormalities. The cornerstone of management of AFLP includes prompt recognition, preparation for delivery, and supportive care such as reversal of coagulopathy. Early diagnosis, delivery, and supportive care have resulted in improved maternal morbidity and mortality. This chapter outlines the epidemiology, etiology, clinical presentation, diagnosis, management, and resolution of AFLP.

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Disclosure Statement

The authors report no conflict of interest.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Parkland Health and Hospital Systems, Dallas, TX, USA

    David B. Nelson, John J. Byrne & F. Gary Cunningham

Authors
  1. David B. Nelson
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  2. John J. Byrne
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  3. F. Gary Cunningham
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Corresponding author

Correspondence to David B. Nelson .

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Editors and Affiliations

  1. Critical Care Obstetrics Unit, Hospital Doctor Arnulfo Arias Madrid, Panama City, Panama

    Carlos Montufar

  2. Division of Critical Care, Karl Heusner Memorial Hospital, Belize City, Belize

    Jorge Hidalgo

  3. Houston Center for Maternal-Fetal Medicine, Houston, TX, USA

    Alfredo F. Gei

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Nelson, D.B., Byrne, J.J., Cunningham, F.G. (2021). Acute Fatty Liver of Pregnancy. In: Montufar, C., Hidalgo, J., Gei, A.F. (eds) Obstetric Catastrophes. Springer, Cham. https://doi.org/10.1007/978-3-030-70034-8_5

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  • DOI: https://doi.org/10.1007/978-3-030-70034-8_5

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  • Online ISBN: 978-3-030-70034-8

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