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Basics of Voice Disorders

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Phoniatrics I

Abstract

The chapter starts with the traditional definition of voice disorders based on main symptoms (hoarseness, limited laryngeal efficiency or vocal endurance, sensations of laryngeal discomfort) and systematic aetiological classification (organic-functional), whereas for ‘functional’, the alternative term ‘malregulative’ is recommended. Relevant parameters of voice production are presented in terms of a clinical and an acoustical setting as a basis for a plausible terminology. The long-lasting controversial discussion on vocal registers is objectified by associating subjective sensations and metaphorical interpretations with underlying mechanisms and typical physiological correlates. Another special view refers to the role of the external laryngeal muscles in voice production. Exact epidemiological data about specific types of voice disorders are still rare. Voice disorders are common in all age groups and in both sexes, with one third of the general population said to experience a voice problem once in their lifetime. The higher the voice load, the higher is the risk of developing a voice problem. An overview of pathology and pathogenesis of dysphonia focuses on malformations, inflammation, systemic diseases, malignancies and traumata affecting the larynx, resonance disorders and presbylaryngis. Current knowledge about the genetics of voice disorders is presented, covering vocal fold microstructure, vocal fold diseases, voice-related genetic syndromes and genetic neurological diseases. The genetic treatment approaches include tissue engineering, the use of technology tools and personalised medicine. A final section on the pathophysiology of voice production concentrates on manifestations such as hoarseness, roughness and breathiness, as well as on the influences of subglottal pressure, transglottal airflow and the supraglottal part of the vocal tract.

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Notes

  1. 1.

    ‘Dysphonia’ or ‘phonatory disorder’ is the more precise phrase because ‘voice disorder’ merely indicates the product ‘voice’ rather than the complex phonatory function.

  2. 2.

    In order that clarity be preserved, this classification does not include the level of cell regulation.

  3. 3.

    Suggested by Pahn and Friemert (<CitationRef CitationID="CR101" >1988</Citation Ref>).

References

  • Abuzeid WM, Li D, O’Malley BW Jr (2011) Gene therapy for head and neck cancer. In: Alford RL, Sutton VR (eds) Medical genetics in the clinical practice of ORL. Karger, Basel, pp 141–151

    Chapter  Google Scholar 

  • Adler NR, Mahony A, Friedman ND (2013) Diphtheria: forgotten, but not gone. Intern Med J 43(2):206–210

    Article  CAS  PubMed  Google Scholar 

  • Akama K, Horikoshi T, Nakayama T et al (2011) Proteomic identification of differentially expressed genes in neural stem cells and neurons differentiated from embryonic stem cells of cynomolgus monkey (Macaca fascicularis) in vitro. Biochim Biophys Acta 1814(2):265–276

    Article  CAS  PubMed  Google Scholar 

  • Akmansu H, Oğuz H, Atasever T et al (2004) Evaluation of sentinel nodes in the assessment of cervical metastases from head and neck squamous cell carcinomas. Tumori 90(6):596–599

    Article  PubMed  Google Scholar 

  • Akst LM, Thompson LDR (2003) Larynx amyloidosis. Ear Nose Throat J 82(11):844–845

    Article  PubMed  Google Scholar 

  • Altman KW (2007) Vocal fold masses. Otolaryngol Clin North Am 40(5):1091–1108

    Article  PubMed  Google Scholar 

  • Andersson-Wallgren G, Ohlsson AC, Albertsson-Wikland K et al (2008) Growth promoting treatment normalizes speech frequency in Turner syndrome. Laryngoscope 118(6):1125–1130

    Article  PubMed  Google Scholar 

  • Auffray C, Charron D, Hood L (2010) Predictive, preventive, personalized and participatory medicine: back to the future. Genome Med 2(8):57

    Article  PubMed  PubMed Central  Google Scholar 

  • Bartels H, Dikkers FG, Lokhorst HM et al (2004) Laryngeal amyloidosis: localized versus systemic disease and update on diagnosis and therapy. Ann Otol Rhinol Laryngol 113(9):741–748

    Article  PubMed  Google Scholar 

  • Barth E (1911) Einführung in die Physiologie, Pathologie und Hygiene der menschlichen Stimme. Thieme, Leipzig, p 411

    Google Scholar 

  • Bartlett RS, Gaston JD, Yen TY et al (2015) Biomechanical screening of cell therapies for vocal fold scar. Tissue Eng Part A 21(17–18):2437–2447. https://doi.org/10.1089/ten.TEA.2015.0168

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Behlau M, Zambon F, Guerrieri AC et al (2012) Epidemiology of voice disorders in teachers and nonteachers in Brazil: prevalence and adverse effects. J Voice 26(5):665.e9–665.18

    Article  Google Scholar 

  • Bhattacharyya N (2014) The prevalence of voice problems among adults in the United States. Laryngoscope 124(10):2359–2362

    Article  PubMed  Google Scholar 

  • Boey HP, Cunningham MJ, Weber AL (1995) Central nervous system imaging in the evaluation of children with true vocal cord paralysis. Ann Otol Rhinol Laryngol 104(1):76–77

    Article  CAS  PubMed  Google Scholar 

  • Böhme G (2004) Sprach-, Sprech-, Stimm- und Schluckstörungen. Urban & Fischer, München, Jena

    Google Scholar 

  • Boone DR, McFarlane SC (2000) The voice and voice therapy, 6th edn. Pearson Education, Needham Heights, MA

    Google Scholar 

  • Bressman SB, Raymond D, Fuchs T et al (2009) Mutations in THAP1 (DYT6) in early-onset dystonia: a genetic screening study. Lancet Neurol 8(5):441–446

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carding PN, Roulstone S, Northstone K et al (2006) The prevalence of childhood dysphonia: a cross-sectional study. J Voice 20(4):623–630

    Article  PubMed  Google Scholar 

  • Castellanos PF, Spector JG, Kaiser TH (1996) Tumors of the larynx and laryngopharynx. In: Ballenger JC et al (eds) Otorhinolaryngology, 15th edn. Williams & Wilkins, Media, PA

    Google Scholar 

  • Charron D (2011) HLA, immunogenetics, pharmacogenetics and personalized medicine. Vox Sang 100(1):163–166

    Article  CAS  PubMed  Google Scholar 

  • Cichocki M, Singer G, Beyerlein S et al (2008) A case of necrotizing enterocolitis associated with adenovirus infection in a term infant with 22q11 deletion syndrome. J Pediatr Surg 43(4):e5–e8

    Article  PubMed  Google Scholar 

  • Cohen SM, Turley R (2009) Coprevalence and impact of dysphonia and hearing loss in the elderly. Laryngoscope 119(9):1870–1873

    Article  PubMed  Google Scholar 

  • Cohen SR, Geller KA, Birns JW et al (1982) Laryngeal paralysis in children: a long-term retrospective study. Ann Otol Rhinol Laryngol 91(4. Pt 1):417–424

    Article  CAS  PubMed  Google Scholar 

  • Cohen SM, Kim J, Roy N et al (2012) Prevalence and causes of dysphonia in a large treatment-seeking population. Laryngoscope 122(2):343–348

    Article  PubMed  Google Scholar 

  • de Gusmão CM, Fuchs T, Moses A et al (2016) Dystonia-causing mutations as a contribution to the etiology of spasmodic dysphonia. Otolaryngol Head Neck Surg 155(4):624–628

    Article  PubMed  PubMed Central  Google Scholar 

  • Deary V, Miller T (2011) Reconsidering the role of psychosocial factors in functional dysphonia. Curr Opin Otolaryngol Head Neck Surg 19(3):150–154

    Article  PubMed  Google Scholar 

  • Dertlioğlu SB, Çalık M, Çiçek D (2014) Demographic, clinical, and radiologic signs and treatment responses of lipoid proteinosis patients: a 10-case series from Şanlıurfa. Int J Dermatol 53(4):516–523. https://doi.org/10.1111/ijd.12254

    Article  PubMed  Google Scholar 

  • Devaney K, Ferlito A, Devaney SL et al (1998) Clinicopathological consultation: Wegener’s granulamatosis of the head and neck. Ann Otol Rhinol Laryngol 107(5):439–445

    Article  PubMed  Google Scholar 

  • Donaldson JD, Maltby CC (1989) Bacterial tracheitis in children. J Otolaryngol 18(3):101–104

    CAS  PubMed  Google Scholar 

  • Duff MC, Proctor A, Yairi E et al (2004) Prevalence of voice disorders in African American and European American preschoolers. J Voice 18(3):348–353

    Article  PubMed  Google Scholar 

  • Echternach M, Sundberg J, Arndt S et al (2010) Vocal tract in female registers—a dynamic real-time MRI study. J Voice 24(2):133–139

    Article  PubMed  Google Scholar 

  • Echternach M, Traser L, Richter B (2012) Perturbation of voice signals in register transitions on sustained frequency in professional tenors. J Voice 26(5):674.e9–674.e15

    Article  Google Scholar 

  • Echternach M, Dollinger M, Sundberg J et al (2013) Vocal fold vibrations at high soprano fundamental frequencies. J Acoust Soc Am 133(2):EL82–EL87

    Article  PubMed  Google Scholar 

  • Echternach M, Birkholz P, Traser L et al (2015) Articulation and vocal tract acoustics at soprano subject’s high fundamental frequencies. J Acoust Soc Am 137(5):2586–2595

    Article  PubMed  Google Scholar 

  • Enflo L, Sundberg J, McAllister A (2013) Collision and phonation threshold pressures before and after loud, prolonged vocalization in trained and untrained voices. J Voice 27(5):527–530

    Article  PubMed  Google Scholar 

  • Erath BD, Zañartu M, Stewart KC et al (2013) A review of lumped-element models of voiced speech. Speech Commun 55(5):667–690

    Article  Google Scholar 

  • Estes SA (1983) Relapsing polychondritis. A case report and literature review. Cutis 32(5):471–474

    CAS  PubMed  Google Scholar 

  • Eysholdt U (2014) Heiserkeit—Biomechanik und quantitative Laryngoskopie. HNO 62(7):541–552. https://doi.org/10.1007/s00106-014-2868-7

    Article  CAS  PubMed  Google Scholar 

  • Ezekowitz RA, Mulliken JB, Folkman J (1992) Interferon alpha-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med 326(22):1456–1463

    Article  CAS  PubMed  Google Scholar 

  • Falk RT, Pickle LW, Brown LM et al (1989) Effect of smoking and alcohol consumption on laryngeal cancer risk in coastal Texas. Cancer Res 49(14):4024–4029

    CAS  PubMed  Google Scholar 

  • Fink B, Demarest R (1978) Laryngeal biomechanics. Harvard University Press, Cambridge

    Google Scholar 

  • Fokstuen S, Bottani A, Medeiros PF et al (1997) Laryngeal atresia type III (glottic web) with 22q11.2 microdeletion: report of three patients. Am J Med Genet 70(2):130–133

    Article  CAS  PubMed  Google Scholar 

  • Gallivan GJ, Landis JN (1991) Sarcoidosis of the larynx: presenting and restoring airway and professional voice. J Voice 47(1):81–94

    Article  Google Scholar 

  • Garcia M (1847) Mémoire sur la voix humaine présenté à l'Académie des Sciences en 1840, 2nd edn. Imprimerie d’E Duverger, Paris

    Google Scholar 

  • Garcia Martins RH, Gonçalvez AM, Benito Pessin AB et al (2014a) Aging voice: presbyphonia. Aging Clin Exp Res 26(1):1–5

    Article  Google Scholar 

  • Garcia Martins RH, Bóia Neves Pereira ER, Hidalgo CB et al (2014b) Voice disorders in teachers. A review. J Voice 28(6):716–724

    Article  Google Scholar 

  • Garcia Martins RH, do Amaral HA, Tavares EL et al (2015) Voice disorders: etiology and diagnosis. J Voice 26(1):1–5

    Google Scholar 

  • Garnier M, Henrich N, Smith J et al (2010) Vocal tract adjustments in the high soprano range. J Acoust Soc Am 127(6):3771–3780

    Article  PubMed  Google Scholar 

  • Gómez-Coello A, Valadez-Jiménez VM, Cisneros B et al (2017) Voice alterations in patients with spinocerebellar ataxia type 7 (SCA7): clinical-genetic correlations. J Voice 31(1):123.e1–123.e5. https://doi.org/10.1016/j.jvoice.2016.01.010

    Article  Google Scholar 

  • Gorelick MH, Baker MD (1994) Epiglottitis in children, 1979 through 1992. Effects of haemophilus influenzae type b immunization. Arch Pediatr Adolesc Med 148(1):47–50

    Article  CAS  PubMed  Google Scholar 

  • Gottlieb B, Beitel LK, Trifiro MA (2007) Androgen insensitivity syndrome [androgen resistance syndrome, testicular feminization. Includes: complete androgen insensitivity syndrome (CAIS), partial androgen insensitivity syndrome (PAIS), mild androgen insensitivity syndrome (MAIS)]. GeneReviews. https://www.researchgate.net/publication/221964322_Androgen_Insensitivity_Syndrome. Accessed 20 Aug 2016

  • Greene FL, Page DL, Fleming ID et al (2002) American joint committee on cancer: AJCC cancer staging manual, 6th edn. Springer Verlag, Berlin, pp 47–57

    Book  Google Scholar 

  • Groen JL, Yildirim E, Ritz K et al (2011) THAP1 mutations are infrequent in spasmodic dysphonia. Mov Disord 26(10):1952–1954. https://doi.org/10.1002/mds.23682. Epub 2011 Apr 29

    Article  PubMed  Google Scholar 

  • Gugatschka M, Ohno S, Saxena A et al (2012) Regenerative medicine of the larynx. Where are we today? A review. J Voice 26(5):670.e7–670.13. https://doi.org/10.1016/j.jvoice.2012.03.009

    Article  Google Scholar 

  • Gundermann H (1970) Die Berufsdysphonie. In: VEB. Thieme, Leipzig

    Google Scholar 

  • Hacki T (2013) Stimmphysiologie, -pathologie und -therapie. In: Hirschberg J et al (eds) Foniátria és társtudományok. Eötvös Kiadó, Budapest

    Google Scholar 

  • Hacki T (2014) Eine Überlegung zur ätiologischen Strukturierung von Stimmstörungen: “dysregulative Dysphonie” statt “funktioneller Dysphonie”. In: Gross M, Schönweiler R (eds) Aktuelle phoniatrische Aspekte. Medical Science GMS Publishing House, Düsseldorf. ISBN 978-3-00-047098-1

    Google Scholar 

  • Halpern M, Hurd JL, Zuckerman JD (2009) Occupational shoulder disorders. In: Matsen F et al (eds) Rockwood and Matsen’s the shoulder. Saunders Elsevier, Philadelphia, pp 1489–1508

    Chapter  Google Scholar 

  • Hartlieb K (1968) Stimm- und Sprachheilkunde aus biokybernetischer Sicht Teil III. Die Korrektur der funktionell gestörten Stimme und Sprache. Folia Phoniatr 20:43–56

    Article  CAS  Google Scholar 

  • Hazenberg AJ, Dikkers FG, Hawkins PN et al (2009) Laryngeal presentation of systemic apolipoprotein A-I-derived amyloidosis. Laryngoscope 119(3):608–615. https://doi.org/10.1002/lary.20106

    Article  CAS  PubMed  Google Scholar 

  • Henrich N (2006) Mirroring the voice from Garcia to the present day: some insights into singing voice registers. Logoped Phoniatr Vocol 31(1):3–14

    Article  PubMed  Google Scholar 

  • Herridge MS, Pearson FG, Downey GP (1996) Subglottic stenosis complicating Wegener’s granulamatosis: surgical repair as a viable treatment option. J Thorac Cardiovasc Surg 111(5):961–966

    Article  CAS  PubMed  Google Scholar 

  • Hill AB (1965) The environment and disease: association or causation? Proc R Soc Med 58(5):295–300

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hirano S (2011) Tissue engineering for voice disorder. JMAJ 54(4):254–257

    Google Scholar 

  • Hollien H, Dew D, Philips P (1971) Phonational frequency ranges of adults. J Speech Hear Res 14(4):755–760

    Article  CAS  PubMed  Google Scholar 

  • Howe MS, McGowan RS (2007) Sound generated by aerodynamic sources near a deformable body, with application to voiced speech. J Fluid Mech 592:367–392

    Article  Google Scholar 

  • Howe MS, McGowan RS (2013) Aerodynamic sound of a body in arbitrary, deformable motion, with application to phonation. J Sound Vib 332(17):3909–3923

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hunt JP, McWhorter AJ (2007) Malignant neoplasms of the larynx. In: Merati AL, Bielamowicz SA (eds) Textbook of laryngology. Plural Publishing, San Diego, CA

    Google Scholar 

  • Izdebski K (2019) Voice assessment. In: Lalwani A (ed) Current diagnosis & treatment in otolaryngology, head and neck surgery, 4th edn. Lange Publications, New York, NY, pp 416–429

    Google Scholar 

  • Izdebski K, Manace ED, Skiljo Haris J (2000) The challenge of determining work related voice/speech disabilities in California. In: Dejonckere P (ed) Occupational voice: care and cure. Kugler, The Hague, pp 149–154

    Google Scholar 

  • Johns MM (2003) Update on the etiology, diagnosis, and treatment of vocal fold nodules, polyps, and cysts. Curr Opin Otolaryngol Head Neck Surg 11(6):456–461

    Article  PubMed  Google Scholar 

  • Kılıç MA, Okur E, Yıldırım I et al (2004) The prevalence of vocal fold nodules in school age children. Int J Pediatr Otorhinolaryngol 68(4):409–412

    Article  Google Scholar 

  • Kiyabu MT, Shibata D, Arnheim N et al (1989) Detection of human papilloma virus in formalin-fixed, invasive squamous cell carcinoma using polymerase chain reaction. Am J Surg Pathol 13(3):221–224

    Article  CAS  PubMed  Google Scholar 

  • Kollbrunner J, Menet AD, Seifert E (2010) Psychogenic aphonia: no fixation even after a lengthy period of aphonia. Swiss Med Wkly 140(1–2):12–17

    Google Scholar 

  • Koufman J, Blalock PD (1982) Classification and approach to patients with functional voice disorders. Ann Otol Rhinol Laryngol 91(4 Pt 1):372–377

    Article  CAS  PubMed  Google Scholar 

  • Kumar P (2004) Radiation therapy in larynx and hypopharynx. In: Cummings CW et al (eds) Otolaryngology head and neck surgery. Elsevier Mosby, pp 2401–2409

    Google Scholar 

  • Kutty JK, Webb K (2010) Vibration stimulates vocal mucosa-like matrix expression by hydrogel-encapsulated fibroblasts. J Tissue Eng Regen Med 4(1):62–72

    CAS  PubMed  PubMed Central  Google Scholar 

  • Laver J (1980) Phonetic description of voice quality. Cambridge University Press, Cambridge

    Google Scholar 

  • Li NY, Dailey S, Thibeault SL (2013) Assessment of fine needle aspiration feasibility and specimen adequacy for molecular diagnostics of benign vocal fold lesions. Laryngoscope 123(4):960–965. https://doi.org/10.1002/lary.23703. Epub 2013 Feb 12

    Article  PubMed  PubMed Central  Google Scholar 

  • Lighthill MJ (1962) Sound generated aerodynamically. Proc R Soc Lond Ser A 267(1329):147–182

    Article  Google Scholar 

  • Lindstrom DR, Wallace J, Loehrl TA et al (2002) Nissen fundoplication surgery for extraesophageal reflux (EER). Laryngoscope 112(10):1762–1765

    Article  CAS  PubMed  Google Scholar 

  • Lisak RP, Truong DD, Carroll WM et al (2007) International neurology. A clinical approach. Wiley-Blackwell, Hoboken, NJ, p 168

    Google Scholar 

  • Lohmann K, Wilcox RA, Winkler S et al (2013) Whispering dysphonia (DYT4 dystonia) is caused by a mutation in the TUBB4 gene. Ann Neurol 73(4):537–545. https://doi.org/10.1002/ana.23829. Epub 2013 Apr 17

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Louis ED, Michalec M (2014) Validity of a screening question for head tremor: an analysis of four essential tremor case samples. Neuroepidemiology 43(1):65–70. https://doi.org/10.1159/000365991. Epub 2014 Oct 16

    Article  PubMed  Google Scholar 

  • Marino J, Johns M III (2014) The epidemiology of dysphonia in the aging population. Curr Opin Otolaryngol Head Neck Surg 22(6):455–459

    Article  PubMed  Google Scholar 

  • Mathieson L (2001) The Voice & Its Disorders, 6th edn. Whurr Publishers, London

    Google Scholar 

  • Mattheus W, Brücker C (2011) Asymmetric glottal jet deflection: differences of two- and three-dimensional models. J Acoust Soc Am 130(6):EL373–EL379

    Article  PubMed  Google Scholar 

  • Mayou R, Farmer A (2002) ABC of psychological medicine: functional somatic symptoms and syndromes. BMJ 325(7358):265–268

    Article  PubMed  PubMed Central  Google Scholar 

  • Milczuk HA, Smith JD, Everts EC (2000) Congenital laryngeal webs: surgical management and clinical embryology. Int J Pediatr Otorhinolaryngol 52(1):1–9

    Article  CAS  PubMed  Google Scholar 

  • Miller DG (2000) Registers in singing: empirical and systematic studies in the theory of the singing voice. Ponsen & Looijen BV, Wageningen

    Google Scholar 

  • Misono S, Peterson CB, Meredith L et al (2014) Psychosocial distress in patients presenting with voice concerns. J Voice 28(6):753–761

    Article  PubMed  PubMed Central  Google Scholar 

  • Mittal R, Erath BD, Plesniak MW (2013) Fluid dynamics of human phonation and speech. Annu Rev Fluid Mech 45(1):437–467

    Article  Google Scholar 

  • Morabia A (2004) A history of epidemiologic methods and concepts. Part I. Birkhauser Verlag, Basel

    Book  Google Scholar 

  • Mörner M, Fransson F, Fant G (1963) Voice register terminology and standard pitch. STL-QPSR 4(4):17–23

    Google Scholar 

  • Morrison MD, Rammage LA (1993) Muscle misuse disorders: description and classification. Acta Otolaryngol 113(3):428–434

    Article  CAS  PubMed  Google Scholar 

  • Mysiorek D, Persky M (1989) Laser endoscopic treatment of laryngocele and laryngeal cysts. Otolaryngol Head Neck Surg 100(6):538–541

    Article  Google Scholar 

  • Nanke Y, Kotake S, Yonemoto K et al (2001) Cricoarytenoid arthritis with rheumatoid arthritis and systemic lupus erythematosus. J Rheumatol 28(3):624–626

    CAS  PubMed  Google Scholar 

  • Oğuz H, Akbulut S (2013) Ses Bozukluklarında Tedavi Seçimi Türkiye Klinikleri. J ENT Spec Topics 6(2):1–9

    Google Scholar 

  • Oğuz H, Tarhan E, Korkmaz M et al (2007) Acoustic analysis findings in objective laryngopharyngeal reflux patients. J Voice 21(2):203–210

    Article  PubMed  Google Scholar 

  • Oren L, Khosla S, Murugappan S et al (2009) Role of subglottal shape in turbulence reduction. Ann Otol Rhinol Laryngol 118(3):232–240

    Article  PubMed  Google Scholar 

  • Pahn J, Friemert K (1988) Differentialdiagnostische und terminologische Erwägungen bei sogenannten funktionellen Störungen im neuropsychiatrischen und phoniatrischen Fachgebiet. 2. Phoniatrischer Aspekt. Folia Phoniatr 40:168–174

    Article  CAS  Google Scholar 

  • Paul BC, Rafii BY, Gandonu S et al (2014) Smad3: an emerging target for vocal fold fibrosis. Laryngoscope 124(10):2327–2331. https://doi.org/10.1002/lary.24723. Epub 2014 May 27

    Article  CAS  PubMed  Google Scholar 

  • Pedersen M, Eeg M (2012) Does treatment of the laryngeal mucosa reduce dystonic symptoms? A prospective clinical cohort study of mannose binding lectin and other immunological parameters with diagnostic use of phonatory function studies. Eur Arch Otorhinolaryngol 269(5):1477–1482

    Article  PubMed  PubMed Central  Google Scholar 

  • Pospiech L, Kuzniar J, Roskowka-Nadolska B et al (1996) Influence of vapours of paint and toxic dusts on mucous membranes of the upper airways in paint and varnish factory workers. Med Pr 47(5):445–453

    CAS  PubMed  Google Scholar 

  • Preciado J, Pérez C, Calzada M et al (2005) Incidencia y prevalencia de los trastornos de la voz en el personal docente de La Rioja Estudio clínico: cuestionario, examen de la función vocal, análisis acústico y vídeolaringoestroboscopia. (Prevalence and incidence studies of voice disorders among teaching staff of La Rioja, Spain. Clinical study: questionnaire, function vocal examination, acoustic analysis and videolaryngostroboscopy). Acta Otorrinolaringol Esp 56(5):202–210

    Article  CAS  PubMed  Google Scholar 

  • Reder PA, Neel HB (1993) Blastomycosis in otolaryngology: review of a large series. Laryngoscope 103(1 Pt 1):53–58

    CAS  PubMed  Google Scholar 

  • Roger G, Denoyelle F, Triglia JM et al (1995) Severe laryngomalacia: surgical indications and results in 115 patients. Laryngoscope 105(10):1111–1117

    Article  CAS  PubMed  Google Scholar 

  • Rousseau B, Abdollahian D, Ohno T et al (2009) Effects of raised phonation on vocal fold gene expression. Otolaryngol Head Neck Surg 141(3):P64–P64

    Article  Google Scholar 

  • Roy N (2003) Functional dysphonia. Curr Opin Otolaryngol Head Neck Surg 11(3):144–148

    Article  PubMed  Google Scholar 

  • Roy N, Merrill RM, Thibeault S et al (2004) Voice disorders in teachers and the general population: effects on work performance, attendance and future career choices. J Speech Lang Hear Res 47(3):542–551

    Article  PubMed  Google Scholar 

  • Roy N, Merrill RM, Gray SD et al (2005) Voice disorders in the general population: prevalence, risk factors, and occupational impact. Laryngoscope 115(11):1988–1995

    Article  PubMed  Google Scholar 

  • Roy N, Stemple J, Merrill RM et al (2007) Epidemiology of voice disorders in the elderly: preliminary findings. Laryngoscope 117(4):628–633

    Article  PubMed  Google Scholar 

  • Samuels TL, Handler E, Syring ML et al (2008) Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 117(9):688–695

    Article  PubMed  Google Scholar 

  • Sataloff RT (1995) Genetics of the voice. J Voice 9(1):16–19

    Article  CAS  PubMed  Google Scholar 

  • Sataloff RT, Willborn A, Prestipino A et al (1993) Histoplasmosis of the larynx. Am J Otolaryngol 14(3):199–205

    Article  CAS  PubMed  Google Scholar 

  • Sattler M, Abidoye O, Salgia R (2008) EGFR-targeted therapeutics: focus on SCCHN and NSCLC. ScientificWorldJournal 8:909–919

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schultz P (2011) Vocal fold cancer. Eur Ann Otorhinolaryngol Head Neck Dis 128(6):301–308

    Article  CAS  PubMed  Google Scholar 

  • Schultz-Coulon HJ (1980) Die Diagnostik der gestörten Stimmfunktion. Arch Otorhinolaryngol 227:1–169

    Article  CAS  PubMed  Google Scholar 

  • Senderek J, Garvey SM, Krieger M et al (2009) Autosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3. Am J Hum Genet 84(4):511–518

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shah RK, Roberson DW, Jones DT (2004) Epiglottitis in the Hemophilus influenza type B vaccine era: changing trends. Laryngoscope 114(3):557–560

    Article  PubMed  Google Scholar 

  • Shen Z, Ye D, Zhang X et al (2010) Inhibitory effect of HuR gene small interfering RNA segment on laryngeal carcinoma Hep-2 cell growth. J Laryngol Otol 124(11):1183–1189

    Article  CAS  PubMed  Google Scholar 

  • Shin JE, Nam SY, Yoo SY et al (2000) Changing trends in clinical manifestations of laryngeal tuberculosis. Laryngoscope 110(11):1950–1953

    Article  CAS  PubMed  Google Scholar 

  • Shipp T, Izdebski K (1975) Vocal frequency and vertical larynx positioning in singers and non-singers. J Acoust Soc Am 58(5):1104–1106

    Article  CAS  PubMed  Google Scholar 

  • Sie KC, McGill T, Healy GB (1994) Subglottic hemangioma: ten years’ experience with the carbon dioxide laser. Ann Otol Rhinol Laryngol 103(3):167–172

    Article  CAS  PubMed  Google Scholar 

  • Sinard RJ, Netterville JL, Ossoff RH (2003) Squamous cell cancer of the larynx. In: Ossoff RH et al (eds) The larynx. Lippincott Williams & Wilkins, Philadelphia, PA

    Google Scholar 

  • Sliwinska-Kowalska M, Niebudek-Bogusz E, Fiszer M et al (2006) The prevalence and risk factors for occupational voice disorders in teachers. Folia Phoniatr Logop 58(2):85–101

    Article  CAS  PubMed  Google Scholar 

  • Solomons NB, Prescott CA (1987) Laryngomalacia. A review and the surgical management. Int J Pediatr Otorhinolaryngol 13(1):31–39

    Article  CAS  PubMed  Google Scholar 

  • Sonninen A (1968) The external frame function in the control of pitch in the human voice. In: Bouhuys A (ed) Sound production in man. Ann N Y Acad Sci 155(1):68–90

    Article  Google Scholar 

  • Sonninen A, Hurme P, Laukkanen AM (1999) The external frame function in the control of pitch, register and singing mode: radiographic observations of a female singer. J Voice 13(3):319–340

    Article  CAS  PubMed  Google Scholar 

  • Stein DJ, Nordzij JP (2013) Incidence of chronic laryngitis. Ann Otol Rhinol Laryngol 122(12):771–774

    Article  PubMed  Google Scholar 

  • Stemple JC (1993) Voice therapy clinical studies. Mosby, St. Louis, MO

    Google Scholar 

  • Stern H (1924) Klinik und Therapie der Krankheiten der Stimme. Mschr Ohrenheilk 58:1–53

    Google Scholar 

  • Stroud RH, Friedman NR (2001) An update on inflammatory disorders of the pediatric airway: epiglottis, croup, and tracheitis. Am J Otolaryngol 22(4):268–275

    Article  CAS  PubMed  Google Scholar 

  • Sulica L (2005) Laryngeal thrush. Ann Otol Rhinol Laryngol 114(5):369–375

    Article  PubMed  Google Scholar 

  • Sundberg J (1975) Formant technique in a professional female singer. Acust 32(2):89–96

    Google Scholar 

  • Sundberg J, Thalen M, Popeil L (2012) Substyles of belting: phonatory and resonatory characteristics. J Voice 26(1):44–50

    Article  PubMed  Google Scholar 

  • Sundberg J, Scherer R, Hess M et al (2013) Subglottal pressure oscillations accompanying phonation. J Voice 27(4):411–421

    Article  PubMed  Google Scholar 

  • Svec JG, Sundberg J, Hertegard S (2008) Three registers in an untrained female singer analyzed by videokymography, strobolaryngoscopy and sound spectrography. J Acoust Soc Am 123(1):347–353

    Article  PubMed  Google Scholar 

  • Tanner K, Sauder C, Thibeault SL et al (2010) Vocal fold bowing in elderly male monozygotic twins: a case study. J Voice 24(4):470–476

    Article  PubMed  Google Scholar 

  • Teitel AD, MacKenzie CR, Stern R et al (1992) Laryngeal involvement in systemic lupus erythematosus. Semin Arthritis Rheum 22(3):203–214

    Article  CAS  PubMed  Google Scholar 

  • Terada M, Izumi K, Ohnuki H et al (2012) Construction and characterization of a tissue-engineered oral mucosa equivalent based on a chitosan-fish scale collagen composite. J Biomed Mater Res B Appl Biomater 100(7):1792–1802

    Article  PubMed  CAS  Google Scholar 

  • The ASHA Leader Blog (2015) The problem of limited health care coverage voice disorder treatment. Podcast: Episode 33. https://blog.asha.org/2015/11/04/limited-health-care-coverage-for-treatment-of-voice-disorders/ Accessed 29 Jan, 2018

  • Thompson DM, Kershner JE (2007) Pediatric laryngology. In: Merati AL, Bielamowicz SA (eds) Textbook of laryngology. Plural Publishing, San Diego, CA

    Google Scholar 

  • Titze IR (1994) Principles of voice production. Prentice-Hall, Englewood Cliffs, NJ

    Google Scholar 

  • Titze IR (2009) Das Saitenblasinstrument Spektrum der Wissenschaft, vol 2, pp 54–60

    Google Scholar 

  • Titze IR, Verdolini Abbott K (2012) Vocology—the science and practice of voice habilitation. National Center for Voice and Speech, Salt Lake City

    Google Scholar 

  • Vaca M, Mora E, Cobeta I (2015) The aging voice: influence of respiratory and laryngeal changes. Otolaryngol Head Neck Surg 153(3):409–413

    Article  PubMed  Google Scholar 

  • Vago B, Hausser I, Hennies HC et al (2007) Hyalinosis cutis et mucosae. J Dtsch Dermatol Ges 5(5):401–405

    Article  PubMed  Google Scholar 

  • Van Borsel J (2004) Voice and resonance disorders in genetic syndromes: a meta-analysis. Folia Phoniatr Logop 56(2):83–92

    Article  PubMed  Google Scholar 

  • Van Houtte E, Van Lierde K, D'Haeseleer E et al (2010) The prevalence of laryngeal pathology in a treatment-seeking population with dysphonia. Laryngoscope 120(2):306–312

    PubMed  Google Scholar 

  • Vemula SR, Xiao J, Zhao Y et al (2014) A rare sequence variant in intron 1 of THAP1 is associated with primary dystonia. Mol Genet Genomic Med 2(3):261–272. https://doi.org/10.1002/mgg3.67. Epub 2014 Feb 11

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Verdolini K, Ramig LO (2001) Review: occupational risks for voice problems. Logoped Phoniatr Vocol 26(1):37–46

    Article  CAS  PubMed  Google Scholar 

  • Verduyckt I, Remacle M, Jamart J et al (2011) Voice-related complaints in the pediatric population. J Voice 25(3):373–380

    Article  PubMed  Google Scholar 

  • Vilkman E, Karma P (1989) Vertical hyoid bone displacement and fundamental frequency of phonation. Acta Otolaryngol 108(1–2):142–151

    Article  CAS  PubMed  Google Scholar 

  • Vilkman E, Sonninen A, Hurme P et al (1996) External laryngeal frame function in voice production revisited: a review. J Voice 10(1):78–92

    Article  CAS  PubMed  Google Scholar 

  • Villanueva-Reyes A (2011) Voice disorders in the metropolitan area of San Juan, Puerto Rico: profiles of occupational groups. J Voice 25(1):83–87

    Article  PubMed  Google Scholar 

  • Vodovotz Y, Constantine G, Faeder J et al (2010) Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol 32(2):181–195

    Article  PubMed  PubMed Central  Google Scholar 

  • Watts CR, Awan SN, Marler JA (2008) An investigation of voice quality in individuals with inherited elastin gene abnormalities. Clin Linguist Phon 22(3):199–213

    Article  PubMed  Google Scholar 

  • Watts CR, Knutsen RH, Ciliberto C et al (2011) Evidence for heterozygous abnormalities of the elastin gene (ELN) affecting the quantity of vocal fold elastic fibers: a pilot study. J Voice 25(2):e85–e90

    Article  PubMed  Google Scholar 

  • Weiss DA (1934) Der Begriff des Funktionellen mit besonderer Berücksichtigung der Sprach- und Stimmheilkunde. Mschr Ohrenheilk 68:830–832

    Google Scholar 

  • Wendler J, Seidner W (1987) Lehrbuch der Phoniatrie, 2nd edn. VEB Georg Thieme, Leipzig

    Google Scholar 

  • Wendler J, Fischer S, Seidner W et al (1985) Stroboglottometric and acoustic measures of natural vocal registers. In: Askenfelt A et al (eds) Proceedings of the Stockholm Music Acoustics Conference 1983 (SMAC 83) 46(1): 261–268. Royal Swedish Academy of Music, Stockholm

    Google Scholar 

  • Wendler J, Dejonckere PH, Wienhausen S et al (2014) Therapeutic consequences from changing voice ideals (clear to harsh, pleasant to jarring): summarizing report on a round-table discussion at the 5th World Voice Congress, Luxor, Egypt, 27-31 October 2012. Logoped Phoniatr Vocol 39(4):188–190

    Article  PubMed  Google Scholar 

  • Wolchok JC, Brokopp C, Underwood CJ et al (2009) The effect of bioreactor induced vibrational stimulation on extracellular matrix production from human derived fibroblasts. Biomaterials 30(3):327–335

    Article  CAS  PubMed  Google Scholar 

  • Woo P, Mendelsohn J, Humphrey D (1995) Rheumatoid nodules of the larynx. Ear Nose Throat J 113(1):147–150

    CAS  Google Scholar 

  • Woodson GE (2003) Laryngitis. In: Ossoff RH et al (eds) The larynx. Lippincott Williams & Wilkins, Philadelphia, PA

    Google Scholar 

  • World Health Organization (2001) International classification of functioning, disability and health (ICF). WHO, Geneva

    Google Scholar 

  • Xu W, Wang L, Zhang L et al (2010) Otolaryngological manifestations and genetic characteristics of lipoid proteinosis. Ann Otol Rhinol Laryngol 119(11):767–771

    PubMed  Google Scholar 

  • Yamashita M, Omori K, Kanemaru S et al (2007a) Experimental regeneration of canine larynx: a trial with tissue engineering techniques. Acta Otolaryngol 127(Suppl 557):66–72

    Article  Google Scholar 

  • Yamashita M, Kanemaru S, Hirano S et al (2007b) Tracheal regeneration after partial resection: a tissue engineering approach. Laryngoscope 117(3):497–502

    Article  PubMed  Google Scholar 

  • Yang A, Berry DA, Kaltenbacher M et al (2012) Three-dimensional biomechanical properties of human vocal folds: parameter optimization of a numerical model to match in vitro dynamics. J Acoust Soc Am 131(2):1378–1390

    Article  PubMed  PubMed Central  Google Scholar 

  • Zenker W, Glaninger J (1959) Die Stärke des Trachealzuges beim lebenden Menschen und seine Bedeutung für die Kehlkopfmechanik. Ztschr Biol 111:155–164

    Google Scholar 

  • Zenker W, Zenker A (1960) Über die Regelung der Stimmlippenspannung durch von außen eingreifende Mechanismen. Folia Phoniatr (Basel) 12(1):1–36

    Article  CAS  Google Scholar 

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Case Study Audio Sample 4.1

Breathy voice (MP3 1895 kb)

Case Study Image 4.1

Voice range profile breathy voice (JPG 181 kb)

Case Study Audio Sample 4.2

Normal male voice (MP3 1850 kb)

Case Study Image 4.2

Voice range profile normal male voice (JPG 187 kb)

Case Study Audio Sample 4.3

Normal female voice (MP3 4490 kb)

Case Study Image 4.3

Voice range profile normal female voice (JPG 180 kb)

Case Study Audio Sample 4.4

Rough voice (MP3 1621 kb)

Case Study Image 4.4

Voice range profile rough voice (JPG 164 kb)

Case Study Audio Sample 4.5

Ventricular fold voice woman (MP3 2261 kb)

Case Study Image 4.5

Voice range profile ventricular fold voice woman (JPG 179 kb)

Case Study Audio Sample 4.6

Vocal sound louis armstrong (MP3 1908 kb)

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Akbulut, S. et al. (2020). Basics of Voice Disorders. In: am Zehnhoff-Dinnesen, A., Wiskirska-Woznica, B., Neumann, K., Nawka, T. (eds) Phoniatrics I. European Manual of Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46780-0_4

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