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DIENESTROL
DIENESTROL
- CAS No.84-17-3
- Chemical Name:DIENESTROL
- CBNumber:CB1312612
- Molecular Formula:C18H18O2
- Formula Weight:266.33
- MOL File:84-17-3.mol
DIENESTROL Property
- Melting point 229 °C
- Boiling point 349.54°C (rough estimate)
- Density 1.184 g/cm3
- refractive index 1.4800 (estimate)
- storage temp. Sealed in dry,Room Temperature
- solubility DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- pka 9.21±0.15(Predicted)
- color Pale Yellow to Pale Beige
- Water Solubility 3mg/L(37 ºC)
- Merck 3104
- BRN 2053694
- CAS DataBase Reference 84-17-3
- EWG's Food Scores 1
- FDA UNII RRW32X4U1F
- ATC code G03CB01,G03CC02
- EPA Substance Registry System Dienestrol (84-17-3)
Safety
- Hazard Codes :Xn,T
- Risk Statements :40-48-62-45
- Safety Statements :22-24/25-45-36/37-53
- WGK Germany :3
- RTECS :SL0580000
- HS Code :2907.29.0500
- Hazardous Substances Data :84-17-3(Hazardous Substances Data)
- Symbol(GHS)
- Signal wordDanger
- Hazard statements H350-H361d
- Precautionary statements P201-P202-P280-P308+P313-P405-P501
DIENESTROL Price
More Price(2)
- Brand: Sigma-Aldrich(India)
- Product number: 46190
- Product name : Dienestrol
- Purity: VETRANAL?, analytical standard
- Packaging: 25MG
- Price: ₹5780.55
- Updated: 2022/06/14
- Buy: Buy
- Brand: TCI Chemicals (India)
- Product number: D0449
- Product name : Dienestrol
- Purity: min. 96.0 %
- Packaging: 100MG
- Price: ₹3400
- Updated: 2022/05/26
- Buy: Buy
DIENESTROL Chemical Properties,Usage,Production
- Chemical Properties Colorless, needles or powder; odorless. Soluble in alcohol; practically insoluble in water; sensitive to light.
- Originator Synestrol,Schering,US,1947
- Uses Medicine (estrogenic hormone).
- Uses Dienestrol is a metabolite of Diethylstilbestrol, a non-steroidal synthetic estrogen derivative.
- Definition ChEBI: An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.
-
Manufacturing Process
Preparation of γ,δ-Bis-(4-Hydroxylphenyl)-Hexane-γ,δ-Diol: A sodium amalgam is prepared containing 6 grams of sodium and 400 grams of mercury. The
amalgam is covered with a solution of 20 grams of 4-hydroxypropiophenone in
a mixture of 30 ml of 5 N sodium hydroxide solution and 220 ml of water and
the mixture is heated to 28°-30°C and stirred gently. The reduction is
accompanied by development of heat and the temperature of the solution
rises to 34°-35°C, and then falls slowly. After 5 hours the alkaline solution is
separated from the mercury and diluted with 3 or 4 times its volume of water,
when, in order to form the benzoyl derivatives of the products, the solution is
vigorously stirred, while it is being cooled, with 20 ml of benzoyl chloride, the
solution being kept at a temperature of 15°-20°C. When the reaction is
completed, the benzoyl derivatives are filtered off, washed with water and
recrystallized from a mixture of benzene and alcohol, when a product with a
melting point of 195°-215°C is obtained.
Preparation of Dienestrol: In order to obtain dienoestrol, 14.6 grams of dry 4,4'-dibenzoate are refluxed with a mixture of 40 ml of acetic anhydride and 40 ml acetylchloride by heating in an oil-bath at about 90°C for 6 hours after which the bath temperature is increased to 120°C and heating continued for a further 18 hours, after which time the evolution of hydrogen chloride practically ceases. The mixture is allowed to cool for several hours and the crystals which separate are filtered off and recrystallized from an alcoholbenzene mixture when the product melts at 210°-222°C. This product is converted into dienoestrol by adding 10.8 grams of it to 100 ml of 10% (w/v) alcoholic potassium hydroxide solution and then refluxing during 1 hour. After dilution with 200 ml of water and filtration from a small amount of insoluble material, dienoestrol is precipitated from the alkaline solution by treatment with carbon dioxide. It is filtered off, washed with water and recrystallized from dilute alcohol after which it melts at 233°-234°C according to US Patent 2,464,203. - brand name Avc/dienestrol;Crinohermal fem;D.v.;Dienostrol cream;Dienstrogen;Dinol;Dufemine;Foragynol;Frein;Klianyi forte;Klianyl;Neo-oestrogenine;Ortho (cream);Ortho dienestrol cream.
- Therapeutic Function Estrogen
- World Health Organization (WHO) Dienestrol is a stilbene derivative. See WHO comment for diethylstilbestrol. Vaginal forms of dienestrol, which were introduced in 1947, are currently available in over 35 countries for the management of hypoestrogenic vaginal atrophy. (Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977)
- Safety Profile Suspected human carcinogen. Human mutation data reported. Experimental reproductive effects. Used as a drug for the treatment of postmenopausal symptoms. When heated to decomposition it emits acrid smoke and irritating fumes.
DIENESTROL Preparation Products And Raw materials
Raw materials
Preparation Products
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84-17-3, DIENESTROLRelated Search:
- ESTRAGUARD
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- 临床标准品
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- 分析标准品
- 甾体激素 (激素,糖皮激素)
- Analytical Standards
- Alphabetic
- Analytical Chromatography Product Catalog
- DID - DIN
- 4,4'-(己-2,4-二烯-3,4-二基)二苯酚
- PERFEMIKER]双烯雌酚,96%
- 4,4'-(己-2,4-二烯-3,4-二基)二苯酚
- 二烯雌酚
- 甲醇中己二烯雌酚溶液,1000ΜG/ML
- 3-二苯酚丁二烯
- 双烯雌酚 标准品
- 3,4-二(对羟基苯基)-2,4-己二烯
- 双烯雌酚(己二烯雌酚)
- 4-双(4-羟苯基)-2
- 4-己二烯
- 3,4-双(4-羟苯基)-2,4-己二烯
- 己二烯雌酚溶液,100PPM
- 3,4-双(对羟基苯基)-2,4-己二烯
- 双烯雌酚
- 己二烯雌酚
- 2,3-二苯酚丁二烯
- 双烯雌酚/己二烯雌酚/2,3-二苯酚丁二烯
- 双稀雌粉
- 84-17-3
- 4,4'-(Hexa-2,4-diene-3,4-diyl)diphenol
- 2,4-Dichlorobenzyl Alcohol Impurity 14 (2,6-Dichlorobenzyl Bromide)
- 4,4'-(Hexa-2,4-diene-3,4-diyl)diphenol
- Dienestrol (1192003)
- DIENESTROL USP/EP/BP
- Dienestrol Solution in Methanol, 1000μg/mL
- Dienestrol CRS
- Dienestrol >
- Dienestrol 0.1
- 4,4'-(2,4-Hexadiene-3,4-diyl)bisphenol
- 3,4-DI(P-OXYPHENYL)-2 4-HEXADIENE 99%
- 3 4-BIS(P-HYDROXYPHENYL)-2 4-HEXADIENE 99%
- 4 4-DIHYDROXY-G D-DIPHENYL-B D-HEXADIENE 99%
- DIENESTROL CRYSTALLINE
- DIENESTROL VETRANAL, 250 MG
- Willnestrol
- Teserene
- Sexadien
- 2,4-Hexadiene, 3,4-bis(4-hydroxyphenyl)-
- Dienestrol Solution, 100ppm
- Oestrora
- 4,4′-Dihydroxy-γ,δ-diphenyl-β,δ-hexadiene
- Dienestrol (125 mg)
- p,p’-(diethylideneethylene)diphenol