Plummer–Vinson syndrome (PVS), also called Paterson–Brown–Kelly syndrome or sideropenic dysphagia, is a rare disease characterized by difficulty in swallowing, iron deficiency anemia, glossitis, cheilosis andesophageal webs.The cause of Plummer-Vinson syndrome (PVS) is unclear. Proposed etiopathogenic mechanisms include iron and nutritional deficiencies, genetic predisposition, and autoimmunity. Seek the underlying cause of iron deficiency anemia (eg, gastrointestinal blood loss, celiac sprue).