Figure_1.tif (299.81 kB)
The Alternative Pathway of Complement: Polymorphic Variants and Complement Proteins under Study.
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posted on 2008-07-02, 02:13 authored by Hendrik P. N. Scholl, Peter Charbel Issa, Maja Walier, Stefanie Janzer, Beatrix Pollok-Kopp, Florian Börncke, Lars G. Fritsche, Ngaihang V. Chong, Rolf Fimmers, Thomas Wienker, Frank G. Holz, Bernhard H. F. Weber, Martin OppermannComplement gene SNPs (boxed with dotted lines) and protein plasma concentrations (boxed with solid lines) were determined in all AMD patients and controls. C3, C4 and factor B are substrates (open rectangles), factor H and factor D are regulators (open ellipses), Ba, C3d and SC5b-9 are markers of chronic activation (filled rectangles), and C3a and C5a are markers of acute activation (filled ellipses) of the alternative complement pathway.
