Aminoglutethimide

Aminoglutethimide is an aromatase inhibitor (IC50 = 7.5 µM). Aromatase inhibitors, including aminoglutethimide, inhibit estrogen synthesis via aromatase, suppressing estrogen levels in post-menopausal women. Formulations containing aromatase inhibitors have been used to treat estrogen receptor-positive breast cancer in post-menopausal women.Formal Name: 3-(4-aminophenyl)-3-ethyl-2,6-piperidinedione. CAS Number: 125-84-8. Synonyms: DL-Aminoglutethimide, NSC 330915. Molecular Formula: C13H16N2O2. Formula Weight: 232.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/mL, DMSO: 10 mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL, Ethanol: 10 mg/mL. lambdamax: 242 nm. SMILES: O=C1NC(C(C2=CC=C(N)C=C2)(CC)CC1)=O. InChi Code: InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17). InChi Key: ROBVIMPUHSLWNV-UHFFFAOYSA-N.