Amperozide
- CAS No.
- 75558-90-6
- Chemical Name:
- Amperozide
- Synonyms
- FG-5606;Amperozide;Amperozida;Amperozidum;4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide;4-[4,4-Bis(4-fluorophenyl)butyl]-N-ethyl-1-piperazinecarboxamide;1-Piperazinecarboxamide, 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethyl-
- CBNumber:
- CB71178020
- Molecular Formula:
- C23H29F2N3O
- Molecular Weight:
- 401.498
- MDL Number:
- MFCD00864603
- MOL File:
- 75558-90-6.mol
| Boiling point | 579.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.151±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| pka | 14.59±0.20(Predicted) |
| FDA UNII | 0M2W3TAG39 |
Amperozide price
Amperozide Chemical Properties,Uses,Production
Originator
Amperozide,Ferrosan
Manufacturing Process
(1). A stirred mixture of 4.7 g (0.03 mole) of N'-ethyl-1-
piperazinecarboxamide, 10.1 g (0.036 mole) of 4-chloro-1,1-(di-pfluorophenyl)
butane, 5.0 g of sodium bicarbonate and 10 ml of ethanol was
heated at reflux for 60 hours. 50 ml of water was added. The mixture was
extracted twice with ether. The combined extracts were dried over sodium
sulfate and concentrated. The residue was dissolved in ethanol-ether and the
hydrochloride was precipitated with hydrogen chloride in ethanol. The solid
was collected by filtration and recrystallised from 2-butanone-isopropanol 4:1
to give 6.4 g of N'-ethyl-4-[4,4-(di-p-fluorophenyl)butyl]-1-
piperazinecarboxamide hydrochloride. Melting point 177-178°C.
(2). A stirred mixture of 9.9 g (0.03 mole) of 1-[4,4-(di-pfluorophenyl)
butyl]piperazine, 5,0 g (0,03 mole) of phenyl N-ethylcarbamate,
6,6 g of potassium carbonate and 100 ml of toluene was heated at reflux for
45 minutes. The mixture was filtered and the solvent was removed. The
residual oil was dissolved in ethanol-ether and the hydrochloride was
precipitated with hydrogen chloride in ethanol. The solid was collected by
filtration and recrystallized from 2-butanone-isopropanol 4:1 to give 6.8 g of
N'-ethyl-4-[4,4-(di-p-fluorophenyl)butyl]-1-piperazinecarboxamide
hydrochloride. Melting point 177-178°C.
Therapeutic Function
Anti-aggressive, Antiarrhythmic
Biological Activity
Atypical antipsychotic that displays high affinity for 5-HT 2 receptors (K i = 26 nM) and low affinity for D 2 receptors. Supresses ethanol drinking in genetically ethanol-preferring rats.
Amperozide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Amperozide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3237 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4392 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2999 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |