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SDHD Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA534387
Description
A suggested positive control is EL4 cell lysate. PA5-34387 can be used with blocking peptide PEP-1430.
The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.Specifications
SDHD | |
Polyclonal | |
Unconjugated | |
SDHD | |
3110001M13Rik; AVLL5809; C78570; CBT1; CII-4; CWS3; CybS; PGL; PGL1; PRO19626; QPs3; SDH4; SDHD; Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex subunit D; succinate dehydrogenase complex subunit D integral membrane protein; succinate dehydrogenase complex, subunit D, integral membrane protein; succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
363061, 6392, 66925 | |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C | |
Liquid |
Immunocytochemistry, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
O14521, Q6PCT8, Q9CXV1 | |
SDHD | |
A 15 amino acid synthetic peptide near the center of human SDHD | |
100 μg | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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