Chronic Lymphocytic Leukemia - Summary
Cancer affecting lymphocytes/ Mature B cell neoplasm. Lymphocytes accumulate in large numbers and are dysfunctional rendering the immune system incompetent. CLL is identical to the non-Hodgkin lymphoma SLL
Epidemiology
Clinical Presentation:
Clinical presentation:
 - Many with no early symptoms
 - lymphadenopathy,  fevers > 100.5 for > 2 weeks w/out infection, Drenching night sweats, Extreme fatigue
Diagnosis:
 - Lymphocytosis on CBC
 - Confirm: Flow cytometry
 - Peripheral smear- Smudge cells or basket cells can indicate disease
 - B cell surface molecules: CD5 and CD23 antigen
 - Matute's CLL Scoring system: DDX between classical CLL and other C Cell lymphoproliferative disorders.
Labs:
  1. Lymphocytosis: Absolute blood lymphocyte > 5000/microL
  2.Cytopenias: Neutropenia, anemia, thrombocytopenia
  3. Immunoglobulin abnormalities: Hypogammaglobulinemia, Polyclonal increase gamma globulins
  4. Elevated LDH
  5. Elevated beta 2 microglobulin
Treatment: Bruton's tyrosine kinase (BTK)

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