Eosinophilic Esophagitis (EoE) - Spectrum of Response

Non-response:

 • Histology: Persistent eosinophilia, ≥ 15 eos/hpf

 • Symptoms: Persistent symptoms, <30% decrease in a symptom metric

 • Endoscopy: Persistent endoscopic findings, <30% decrease in EREFS

Response:

 • Histology: Reduced eosinophilia, 7-14 eos/hpf 1-6 eos/hpf

 • Symptoms: Decreased symptoms, 30-90% decrease in a symptom metric

 • Endoscopy: Improved findings, EREFS score ≥2 but less than baseline

Complete Normalization:

 • Histology: Normal biopsy, <1 eos/hpf

 • Symptoms: Symptom resolution, >90% decrease in a symptom metric; EEsAl score < 20

 • Endoscopy: Normal esophagus, EREFS score < 2



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