Hypomagnesemia - Etiologies by Mechanism



Decreased GI Uptake 

 - Poor dietary intake (particularly common in alcoholics)

 - Proton-pump inhibitors

 - Primary intestinal hypomagnesemia

Excessive GI losses 

 - Chronic diarrhea / IBD 

Renal Loses 

 - Medications 

   - Loop and thiazide diuretics 

   - Amphotericin B 

   - Aminoglycosides 

   - Cisplatin 

   - Calcineurin inhibitors 

 - Electrolyte abnormalities 

   - Hypercalcemia 

   - Hypokalemia 

 - Osmotic diuresis 

   - Uncontrolled diabetes 

   - Post-obstructive diuresis 

 - Transient renal tubular dysfunction 

   - Alcohol 

 - Familial renal Mg wasting syndromes 

   - Gitelman syndrome 

   - Genetic defects affecting claudin-16

Miscellaneous Mechanisms 

 - Pancreatitis

 - Hungry bones syndrome



Dr. Eric Strong https://twitter.com/DrEricStrong 



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