Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Commentary
  • Published:

Grand Challenge Commentary: Synthetic immunology to engineer human immunity

Nature Chemical Biology volume 6, pages 871–872 (2010)Cite this article

Subjects

Rationally designing new strategies to control the human immune response stands as a key challenge for the scientific community. Chemical biologists have the opportunity to address specific issues in this area that have important implications for both basic science and clinical medicine.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Schematic diagram depicting how the combined application of chemical, biological and clinical technologies could address the challenges posed by synthetic immunology, leading to advances in both basic research and the development of therapeutic agents.

References

  1. Budynek, P., Dabrowska, K., Skaradzinski, G. & Gorski, A. Arch. Microbiol. 192, 315–320 (2010).

    Article  CAS  Google Scholar 

  2. Liu, S.-C. et al. Cancer Res. 68, 7995–8003 (2008).

    Article  CAS  Google Scholar 

  3. Nelson, J. et al. ACS Chem. Biol. published online, doi:10.1021/cb100195d (17 August 2010).

  4. Zhang, A.X. et al. J. Am. Chem. Soc. 132, 12711–12716 (2010).

    Article  CAS  Google Scholar 

  5. Carlson, C.B., Mowery, P., Owen, R.M., Dykhuizen, E.C. & Kiessling, L.L. ACS Chem. Biol. 2, 119–127 (2007).

    Article  CAS  Google Scholar 

  6. Popkov, M., Gonzalez, B., Sinha, S.V. & Barbas, C.F. III. Proc. Natl. Acad. Sci. USA 106, 4378–4383 (2009).

    Article  CAS  Google Scholar 

  7. Low, P.S., Henne, W. & Doorneweerd, D. Acc. Chem. Res. 41, 120–129 (2008).

    Article  CAS  Google Scholar 

  8. Kodadek, T. Curr. Opin. Chem. Biol. published online, doi:10.1016/j.cbpa.2010.07.002 (31 July 2010).

  9. Cobaleda, C., Jochum, W. & Busslinger, M. Nature 449, 473–477 (2007).

    Article  CAS  Google Scholar 

  10. Yamanaka, S. & Blau, H.M. Nature 465, 704–712 (2010).

    Article  CAS  Google Scholar 

  11. Zhu, S., Wurdak, H. & Schultz, P.G. Future Med. Chem. 2, 965–973 (2010).

    Article  CAS  Google Scholar 

  12. Borowiak, M. et al. Cell Stem Cell 4, 348–358 (2009).

    Article  CAS  Google Scholar 

  13. Zhou, H. & Ding, S. Curr. Opin. Hematol. 17, 276–280 (2010).

    Article  Google Scholar 

  14. Kantoff, P.W. et al. N. Engl. J. Med. 363, 411–422 (2010).

    Article  CAS  Google Scholar 

  15. Puffer, E.B., Pontrello, J.K., Hollenbeck, J.J., Kink, J.A. & Kiessling, L. ACS Chem. Biol. 2, 252–262 (2007).

    Article  CAS  Google Scholar 

  16. Zhu, J., Warren, J.D. & Danishefsky, S.J. Expert Rev. Vaccines 8, 1399–1413 (2009).

    Article  CAS  Google Scholar 

  17. Adams, M.M. et al. J. Am. Chem. Soc. 132, 1939–1945 (2010).

    Article  CAS  Google Scholar 

  18. Shaha, S.P. et al. Clin. Exp. Immunol. 158, 186–198 (2009).

    Article  CAS  Google Scholar 

  19. Kaiser, A. et al. Angew. Chem. Int. Edn Engl. 48, 7551–7555 (2009).

    Article  CAS  Google Scholar 

  20. Grünewald, J. et al. Proc. Natl. Acad. Sci. USA 106, 4337–4342 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. David A. Spiegel is in the Departments of Chemistry and Pharmacology, Yale University, New Haven, Connecticut, USA.,

    David A Spiegel

Authors
  1. David A Spiegel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David A Spiegel.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Spiegel, D. Grand Challenge Commentary: Synthetic immunology to engineer human immunity. Nat Chem Biol 6, 871–872 (2010). https://doi.org/10.1038/nchembio.477

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.477

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research