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The cavefish Astyanax mexicanus

Nature Methods volume 20, pages 948–950 (2023)Cite this article

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Astyanax mexicanus exists in two forms: a surface form that is abundantly distributed throughout freshwater bodies in Middle America and a blind subterranean form endemic to caves in northeastern Mexico. These diverse fish populations have become a vertebrate model for investigating the genetic basis of environmental adaptation.

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Fig. 1: The research organism.

Stowers Institute

Fig. 2: Pan-neuronally expressing Ca2+ indicator (GCaMP) transgenic line of Astyanax mexicanus.

References

  1. Hubbs, C. L. Occasional Pap. Mus. Zool. Univ. Mich. 342, 1–9 (1936).

    Google Scholar 

  2. Aspiras, A. C., Rohner, N., Martineau, B., Borowsky, R. L. & Tabin, C. J. Proc. Natl Acad. Sci. USA 112, 9668–9673 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Xiong, S., Krishnan, J., Peuß, R. & Rohner, N. Dev. Biol. 441, 297–304 (2018).

    Article  CAS  PubMed  Google Scholar 

  4. Riddle, M. R. et al. Nature 555, 647–651 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Xiong, S. et al. Curr. Biol. 32, 2272–2280.e6 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Olsen, L. et al. Proc. Natl Acad. Sci. USA 120, e2204427120 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Krishnan, J. et al. Nat. Genet. 54, 684–693 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Medley, J. K. et al. eLife 11, e74539 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Peuß, R. et al. Nat. Ecol. Evol. 4, 1416–1430 (2020).

    Article  PubMed  Google Scholar 

  10. Duboué, E. R., Keene, A. C. & Borowsky, R. L. Curr. Biol. 21, 671–676 (2011).

    Article  PubMed  Google Scholar 

  11. Yoshizawa, M., Goricki, S., Soares, D. & Jeffery, W. R. Curr. Biol. 20, 1631–1636 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. van der Weele, C. M. & Jeffery, W. R. eLife 11, e69109 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Hyacinthe, C., Attia, J. & Rétaux, S. Nat. Commun. 10, 4231 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  14. O’Quinn, K. M. S. In Biology and Evolution of the Mexican Cavefish (eds Keene, A. C., Yoshizawa, M. & McGaugh, S. E.) Ch. 6, 111–135 (Academic Elsevier, 2016).

  15. Borowsky, R. Curr. Biol. 18, R23–R24 (2008).

    Article  CAS  PubMed  Google Scholar 

  16. Shimobayashi, M. et al. eLife 12, e85103 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  17. McGaugh, S. E. et al. Nat. Commun. 5, 5307 (2014).

    Article  CAS  PubMed  Google Scholar 

  18. Warren, W. C. et al. Nat. Commun. 12, 1447 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Imarazene, B. et al. Curr. Biol. 31, 4800–4809.e9 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Lloyd, E. et al. Curr. Biol. 32, 3720–3730.e3 (2022).

    Article  CAS  PubMed  Google Scholar 

  21. Krishnan, J. et al. J. Exp. Zoolog. B Mol. Dev. Evol. 334, 530–539 (2020).

    Article  CAS  Google Scholar 

  22. Stahl, B. A. et al. Dev. Dyn. 248, 679–687 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Torres-Paz, J. & Rétaux, S. Front. Cell Dev. Biol. 9, 667296 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  24. Krishnan, J. et al. Sci. Rep. 12, 10115 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Klaassen, H., Wang, Y., Adamski, K., Rohner, N. & Kowalko, J. E. Dev. Biol. 441, 313–318 (2018).

    Article  CAS  PubMed  Google Scholar 

  26. Loomis, C. et al. Front. Neuroanat. 13, 88 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  27. Rohner, N., Perathoner, S., Frohnhöfer, H. G. & Harris, M. P. Zebrafish 8, 119–123 (2011).

    Article  CAS  PubMed  Google Scholar 

  28. Laurent Legendre, J. R. Preprint at bioRxiv https://doi.org/10.1101/2022.12.01.518679 (2022).

Download references

Acknowledgements

I thank the current and former members of my lab, who make coming to work every day a pleasure, and the Stowers Institute for its generous support. I also thank the cavefish community for being the most supportive and collaborative community out there, which makes it truly special to be a part of. Our research is supported by NIH New Innovator Award 1DP2AG071466-01.

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  1. Stowers Institute for Medical Research, Kansas City, MO, USA

    Nicolas Rohner

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  1. Nicolas Rohner
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Correspondence to Nicolas Rohner.

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The author declares no competing interest.

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Rohner, N. The cavefish Astyanax mexicanus. Nat Methods 20, 948–950 (2023). https://doi.org/10.1038/s41592-023-01916-w

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