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m-Iodobenzylguanidine hemisulfate salt (CAS 80663-95-2) - chemical structure image

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m-Iodobenzylguanidine hemisulfate salt (CAS 80663-95-2) - chemical structure image
m-Iodobenzylguanidine hemisulfate salt: sc-200865

m-Iodobenzylguanidine hemisulfate salt (CAS 80663-95-2)

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Alternate Names:
MIBG
Application:
m-Iodobenzylguanidine hemisulfate salt is an inhibitor of arginine specific mono-ADP-ribosyltransferase
CAS Number:
80663-95-2
Purity:
≥99%
Molecular Weight:
324.13
Molecular Formula:
C8H10IN3•1/2H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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m-Imodobenzylguanidine is a norephinephrine analog anti-tumor agent and radiopharmaceutical in its radioiodinated form. Has shown anti-tumor effects on L1210 leukemia and N1E1115 neuroblastoma. Useful for diagnosing and treating adrenergic/neuroendocrine. Blocks ADP-ribosylation-dependent signal transduction pathways.

References:

  1. Bioavailability and toxicity after oral administration of m-iodobenzylguanidine (MIBG).  |  Kuin, A., et al. 1999. Br J Cancer. 79: 802-6. PMID: 10070872
  2. Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-iodobenzylguanidine.  |  Ekelund, S., et al. 2000. Biochem Pharmacol. 60: 839-49. PMID: 10930539
  3. m-iodobenzylguanidine increases the mitochondrial Ca2+ pool in isolated hepatocytes.  |  Juedes, MJ., et al. 1992. FEBS Lett. 313: 39-42. PMID: 1426266
  4. Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay.  |  Gerö, D., et al. 2007. Int J Mol Med. 20: 749-61. PMID: 17912470
  5. Decreased cardiac MIBG uptake, its correlation with clinical symptoms in dementia with Lewy bodies.  |  Kobayashi, S., et al. 2009. Psychiatry Res. 174: 76-80. PMID: 19766460
  6. Radioiodinated metaiodobenzylguanidine treatment of neuroendocrine tumors in adults.  |  Postema, EJ. and McEwan, AJ. 2009. Cancer Biother Radiopharm. 24: 519-25. PMID: 19877881
  7. Meta-iodobenzylguanidine (MIBG), a novel high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation).  |  Loesberg, C., et al. 1990. Biochim Biophys Acta. 1037: 92-9. PMID: 2104758
  8. Impaired mitochondrial respiration and stimulated glycolysis by m-iodobenzylguanidine (MIBG).  |  Loesberg, C., et al. 1990. Int J Cancer. 46: 276-81. PMID: 2384275
  9. Inhibition of ADP-ribosylation suppresses aberrant accumulation of lipidated apolipoprotein B in the endoplasmic reticulum.  |  Ohsaki, Y., et al. 2013. FEBS Lett. 587: 3696-702. PMID: 24100140
  10. Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington′s Disease Model through the Application of Quantitative Systems Pharmacology.  |  Pei, F., et al. 2017. Sci Rep. 7: 17803. PMID: 29259176
  11. Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR.  |  Rao, L., et al. 2021. EMBO Rep. 22: e50613. PMID: 33345425
  12. Cytotoxic and antitumor effects of the norepinephrine analogue meta-iodo-benzylguanidine (MIBG).  |  Smets, LA., et al. 1988. Cancer Chemother Pharmacol. 21: 9-13. PMID: 3342472
  13. Renal toxicity of the neuron-blocking and mitochondriotropic agent m-iodobenzylguanidine.  |  Kuin, A., et al. 1998. Cancer Chemother Pharmacol. 42: 37-45. PMID: 9619756
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