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Moenomycin complex (CAS 11015-37-5) - chemical structure image

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Moenomycin complex (CAS 11015-37-5) - chemical structure image
Moenomycin complex: sc-362031

Moenomycin complex (CAS 11015-37-5)

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Alternate Names:
Flavomycin; Bambermycin
Application:
Moenomycin complex is an antibiotic and selective inhibitor of the transglycosylation step
CAS Number:
11015-37-5
Purity:
≥95%
Molecular Weight:
1583.58
Molecular Formula:
C69H107N4O35P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Moenomycin complex is a mixture of five major components: A, A12, C1, C3 and C4 isolated from several strains of Streptomyces in the 1960s. Moenomycins are high molecular weight phosphoglycolipids with potent antibiotic activity used in animal health. Moenomycins are the only antibiotic known to selectively inhibit the transglycosylation step catalysed by penicillin-binding protein 1b.

References:

  1. Influence of different medium components on the in vitro activity of the growth-promoting antibiotic flavomycin against enterococci.  |  Butaye, P., et al. 2000. J Antimicrob Chemother. 46: 713-6. PMID: 11062189
  2. Influence of flavomycin on ruminal fermentation and microbial populations in sheep.  |  Edwards, JE., et al. 2005. Microbiology (Reading). 151: 717-725. PMID: 15758218
  3. Influence of flavomycin on microbial numbers, microbial metabolism and gut tissue protein turnover in the digestive tract of sheep.  |  Edwards, JE., et al. 2005. Br J Nutr. 94: 64-70. PMID: 16115334
  4. Adaptation to flavomycin in the ruminal bacterium, Prevotella bryantii.  |  Edwards, JE., et al. 2008. J Appl Microbiol. 104: 1617-23. PMID: 18194251
  5. Flavomycin effects on performance of beef bulls and nutrient digestibility in wethers.  |  De Schrijver, R., et al. 1991. Dtsch Tierarztl Wochenschr. 98: 47-50. PMID: 2026115
  6. Effect of bambermycins (Flavomycin) in diets for growing turkeys.  |  Salmon, RE. and Stevens, VI. 1990. Poult Sci. 69: 1133-40. PMID: 2235832
  7. Effects of flavomycin and probiotic supplementation to diets containing different sources of fat on growth performance, intestinal morphology, apparent metabolizable energy, and fat digestibility in broiler chickens.  |  Sharifi, SD., et al. 2012. Poult Sci. 91: 918-27. PMID: 22399731
  8. Monensin, virginiamycin, and flavomycin in a no-roughage finishing diet fed to zebu cattle.  |  Lemos, BJ., et al. 2016. J Anim Sci. 94: 4307-4314. PMID: 27898865
  9. Effects of xylo-oligosaccharide and flavomycin on the immune function of broiler chickens.  |  Yuan, L., et al. 2018. PeerJ. 6: e4435. PMID: 29527412
  10. The Effects of Flavomycin and Colistin Sulfate Pre-Treatment on Ileal Bacterial Community Composition, the Response to Salmonella typhimurium and Host Gene Expression in Broiler Chickens.  |  He, Y., et al. 2019. Microorganisms. 7: PMID: 31752202
  11. Effects of Flavomycin, Bacillus licheniformis and Enramycin on Performance, Nutrient Digestibility, Gut Morphology and the Intestinal Microflora of Broilers.  |  Wang, HL., et al. 2016. J Poult Sci. 53: 128-135. PMID: 32908375
  12. Effects of supplementation with narasin, salinomycin, or flavomycin on performance and ruminal fermentation characteristics of Bos indicus Nellore cattle fed with forage-based diets.  |  Limede, AC., et al. 2021. J Anim Sci. 99: PMID: 33861855
  13. Influence of supplemental flavomycin on growth performance, carcass characteristics, and nutrient digestibility in calf-fed Holstein steers.  |  Carvalho, PHV., et al. 2023. Transl Anim Sci. 7: txad005. PMID: 36777098
  14. The effect of flavomycin on the synthesis and transfer of lipid-linked saccharides in pig brain.  |  Bause, E. and Legler, G. 1982. Biochem J. 201: 481-7. PMID: 6178396
  15. Bioefficacy of enzyme preparations containing beta-glucanase and xylanase activities in broiler diets based on barley or wheat, in combination with flavomycin.  |  Esteve-Garcia, E., et al. 1997. Poult Sci. 76: 1728-37. PMID: 9438289

Good day, We are looking for an anlaytical standard for Flavomycin for testing purposes. Please advise if this product would be suitable for our needs. Thank you

Asked by: Jenna
Thank you for your question. It has not been evaluated as an analytical standard. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot.
Answered by: Tech Service
Date published: 2020-06-02
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Rated 5 out of 5 by from Moenomycin - excellentWe bought Moenomycin complex and are very pleased with its good quality.
Date published: 2020-02-25
Rated 5 out of 5 by from VilletVillet, RA. et al. (PubMed 24509312) found that Flavomycin (Moenomycin complex) exposed to S. aureus strain MW2 produced an increase in abcA transcripts. -SCBT Publication Review
Date published: 2015-05-25
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Moenomycin complex | CAS 11015-37-5 is rated 5.0 out of 5 by 2.
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