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Piperonyl Butoxide: sc-208174
Piperonyl Butoxide (CAS 51-03-6)
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Application:
Piperonyl Butoxide is An insecticide synergist
CAS Number:
51-03-6
Molecular Weight:
338.44
Molecular Formula:
C19H30O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Piperonyl butoxide is a non-toxic substance that acts as a synergist to enhance the effectiveness of insecticides, such as carbamates, pyrethrins, pyrethroids, and rotenone, by inhibiting the mixed-function oxidase (MFO) system of insects. This system is responsible for breaking down insecticides and acts as the natural defense mechanism of the insect. By inhibiting this system, piperonyl butoxide can promote higher levels of insecticide and reduce the required dosage for lethal effect.
References:
- Piperonyl butoxide activates c-Jun and ATF-2 in the hepatocytes of mice. | Muguruma, M., et al. 2008. Arch Toxicol. 82: 749-53. PMID: 18228000
- Piperonyl butoxide increases oxidative toxicity of fenthion in the brain of Oreochromis niloticus. | Üner, N., et al. 2014. J Biochem Mol Toxicol. 28: 84-90. PMID: 24497177
- Effects of piperonyl butoxide on exploratory behaviour in female mice. | Tanaka, T., et al. 2019. Toxicol Ind Health. 35: 314-323. PMID: 30871449
- Piperonyl Butoxide Enhances the Insecticidal Toxicity of Nanoformulation of Imidacloprid on Culex pipiens (Diptera: Culicidae) Mosquito. | Ahmed, MAI. and Othman, AA. 2020. Vector Borne Zoonotic Dis. 20: 134-142. PMID: 31408394
- Synergist piperonyl butoxide enhances the efficacy of deltamethrin in deltamethrin-resistant Anopheles culicifacies sensu lato in malaria endemic districts of Odisha State, India. | Sahu, SS., et al. 2019. Indian J Med Res. 149: 554-557. PMID: 31411181
- Examining the developmental toxicity of piperonyl butoxide as a Sonic hedgehog pathway inhibitor. | Rivera-González, KS., et al. 2021. Chemosphere. 264: 128414. PMID: 33007564
- Piperonyl butoxide, a synergist of pesticides can elicit male-mediated reproductive toxicity. | Bae, JW. and Kwon, WS. 2021. Reprod Toxicol. 100: 120-125. PMID: 33515694
- Developmental and reproduction toxicity of piperonyl butoxide part 2 developmental safety of piperonyl butoxide in the NZW rabbit. | Hoberman, AM. and Hauswirth, JW. 2022. Reprod Toxicol. 112: 177-181. PMID: 35931401
- Developmental and reproduction toxicity of piperonyl butoxide part 3 two generation (two litter) reproduction study of piperonyl butoxide administered in the diet to CD ® (Sprague Dawley) rats. | Hoberman, AM. and Hauswirth, JW. 2022. Reprod Toxicol. 113: 85-95. PMID: 35963517
- Effects of Piperonyl Butoxide on the Accumulation of Lipid and the Transcript Levels of DtMFP alpha in Dunaliella tertiolecta. | Dai, JL., et al. 2022. J Agric Food Chem. 70: 12074-12084. PMID: 36122177
- Laboratory and semi-field efficacy evaluation of permethrin-piperonyl butoxide treated blankets against pyrethroid-resistant malaria vectors. | Azizi, S., et al. 2022. Sci Rep. 12: 22166. PMID: 36550139
- Piperonyl butoxide, alpha[2-(2-butoxyethoxy)ethoxy]-4,5-methylenedioxy-2-propyltoluene: a review of the literature. | Haley, TJ. 1978. Ecotoxicol Environ Saf. 2: 9-31. PMID: 398254
- Piperonyl butoxide induces hepatocellular carcinoma in male CD-1 mice. | Takahashi, O., et al. 1994. Arch Toxicol. 68: 467-9. PMID: 7979964