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sulfalene (CAS 152-47-6)

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CAS Number:
152-47-6
Purity:
≥98%
Molecular Weight:
280.30
Molecular Formula:
C11H12N4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sulfalene, a colorless crystalline solid, is a sulfonamide compound widely utilized in scientific research. With its molecular weight of approximately 215 and a melting point of around 155°C, it possesses distinctive properties that make it valuable in various scientific investigations. Sulfalene exhibits solubility in water, alcohol, and ether, contributing to its versatility in research applications. Notably, this compound acts as an inhibitor for the enzyme dihydropteroate synthetase (DHPS), a vital player in the synthesis of folic acid—an essential nutrient crucial for cellular growth and function. By impeding DHPS, sulfalene disrupts the production of folic acid, ultimately leading to cellular demise

References:

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  2. Simultaneous quantitative analysis of the antimalarials pyrimethamine and sulfamethoxypyrazine in plasma samples using liquid chromatography/tandem mass spectrometry.  |  Storme, ML., et al. 2006. Rapid Commun Mass Spectrom. 20: 2947-53. PMID: 16952211
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  5. Nitrogen-14 nuclear quadrupole resonance spectroscopy: a promising analytical methodology for medicines authentication and counterfeit antimalarial analysis.  |  Barras, J., et al. 2013. Anal Chem. 85: 2746-53. PMID: 23384229
  6. Development of a simple, rapid, and robust liquid chromatographic method for the simultaneous determination of sulfalene, sulfadoxine, and pyrimethamine in tablets.  |  Mwalwisi, YH., et al. 2016. J Pharm Biomed Anal. 129: 558-570. PMID: 27505128
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