I iclude what is GOODPSSTURE syndrome,when and where is it occur and their causes , symptoms,diagnosis,treatment.
Finally their complications & How is it prevent.
3. SYNDROME
A group of symptoms which consistently occur together.
(OR)
A condition characterized by a set of associated
symptoms.
A syndrome is a collection of signs & symptoms
associated with a specific health-related causes.
4. GOODPASTURE SYNDROME
Good pasture is a rare & potentially life threatening disease.
An autoimmune disease.
Damages both the lungs and the kidneys.
It is also known as anti-glomerular basement membrane
(anti-GBM) disease.
the disease is most common at two times of life: in a
person’s 20s and later around their 60s.
5. WHY IT IS CALLED GOOD PASTURE
SYNTROME?
The disorder names after
Dr.Ernest Goodpasture.
Goodpasture,who first
identified the syndrome in
1919.
For reasons that aren’t
clear.
It’s estimated to occur in 1
out of 1 million people per
year.
6.
7. CAUSES OF GOODPASTURE
SYNDROME
Some behaviours & environmental factors.
RTI may trigger the immune system.
Exposure to hydrocarbon fumes (Viral RI), metallic dust,
tobacco smoke (or) certain drugs such as cocaine.
Due to genetics – a specific HLA, known as DR15, is found
in 88% of people who have this syndrome.
8. CAUSES OF GOODPASTURE
SYNDROME
Syndrome develop substances that attack a protein called
collagen (air sac - lungs ; glameruli - kidney).
Substance – Antiglomerular basement membrane Ab.
This membrane act as a filter, to filter waste from blood.
Membrane damage which leads to kidney damage.
Immune system fault – bleeding in the air sac of lungs &
inflamation in the kidney’s filtering unit.
9. CAUSES OF GOODPASTURE
SYNDROME
In the kidney, this affect the glomeruli, the tiny filters in the
kidney that help remove excess water and waste products
from your blood, turning them into the urine.
In the lung, it can affect the alveoli ,the tiny sacs of air
where oxygen and carbon dioxide are exchanged.
The immune activation and inflammation then lead to the
symptoms of the condition. Abnormal activated antibodies
are called anti-GBM antibodies.
Genetics also play a role in triggering Goodpasture
syndrome. People with certain variants of specific genes .
10. SYMPTOMS OF GOODPASTURE
SYNDROME
Symptoms may occur very slowly over months or even
years, but the often develop very quickly over a days
to week.
i. Initial Symptoms.
ii. Lung damage symptoms
iii. Kidney damage symptoms.
12. SYMPTOMS OF GOODPASTURE
SYNDROME
LUNG SYMPTOMS
Coughing up blood (Hemoptysis)
Dry cough
Shortness of breath
Respiratory failure
Chills and fever
Fatigue
Shortness of breath
Chest pain
13. SYMPTOMS OF GOODPASTURE
SYNDROME
LUNG SYMPTOMS
In some cases, can cause severe pulmonary hemorrhage:
bleeding from the lung and other parts of the respiratory
tract.
This may indirectly lead to anemia, low counts of red
blood cells.
If more severe, blood may block the exchange of oxygen
in the small sacs of the lungs. This may cause respiratory
failure,a life-threatening condition in which the body
does not receive enough oxygen.
14. SYMPTOMS OF GOODPASTURE
SYNDROME
KIDNEY SYMPTOMS
Bloody urine
Burning sensation when urinating
Pale skin
Elevated blood pressure reading
Swelling in leg ( any area of body)
Back pain below your ribs
Nausea and vomiting
Increased blood pressure
Back pain (area below the ribs)
Fatigue
Itching
Confused thinking
Seizures
15. SYMPTOMS OF GOODPASTURE
SYNDROME
KIDNEY SYMPTOMS
Condition called glomerulonephritis.
That just refers to inflammation of a specific part of the
kidney called the glomerulus.
If kidney problems are severe, it can lead to uremia. This
a potentially life-threatening condition from having too
high levels of a waste product called urea in your blood.
• .
18. SYMPTOMS OF GOODPASTURE
SYNDROME
Goodpasture syndrome occurs along with another condition
called autoimmune inner ear disease.
This can lead to symptoms such as:
Fullness in the ear
Ringing in the ear
Dizziness
Sudden hearing loss
19. DIAGNOSIS
Urinalysis results are often abnormal,& show blood and
protein in the urine.
Ubnormal RBC may be seen.
Following test may also be done;
Arterial blood gas
BUN
Chest X- Ray
Creatinine (Serum)
Lung biopsy
Kidney biopsy
Blood test (Antiglomerular basement membrane test)
Analysis of a urine sample (gives information about
kidney function)
Chest X-ray (can show pulmonary hemorrhage)
Pulmonary function tests
20. TREATMENT OF GOODPASTURE
SYNDROME
Early treatment focuses on two things:
1. Rapidly removing anti-GBM antibodies from the blood
Process called plasmapheresis.
Blood is removed from their body via a needle and connected
to a machine.
2. Stopping anti-GBM antibodies future production.
This is done by suppressing a person’s immune system.
Some of the following medications might be used for this
purpose:
Corticosteroids
Cyclophosphamide
Azathioprine
Emergency hemodialysis is also sometimes necessary. This helps
perform some of the kidney’s functions to eliminate waste from the
body
21. PREVENTION OF GOODPASTURE
SYNDROME
Never sniff glue or siphon gasoline with your mouth ,
which exposes the lungs to hydrocarbon solvents and
can cause the disease.
Don’t smoke