Flagyl 250mg: Uses, dosage, side effects

Flagyl 250 mg drug belongs to the group of antibacterial and antiparasitic drugs. The drug is used in the case of bacterial infections and parasites sensitive to the nitro 5-imidazol group. For each specific case, the use of the drug is different. Let's learn some characteristics of the uses, dosage, side effects and notes when using Flagyl 250mg through the article below.

Flagyl 250 mg drug has the main active ingredient metronidazole 250mg. This is a drug with antibacterial and antiparasitic effects of the nitro-5- imidazole group.
The drug has a destructive effect on groups of bacteria and parasites including:
Kills HP bacteria (helicobacter pylori). Kills anaerobic bacteria such as: Bacteroides fragilis, Bifidobacterium, Biophilia, Clostridium, Clostridium difficile, Clostridium perfringens, Eubacterium, Fusobacterium, Peptostreptococcus, Prevotella, Porphyromonas, Veillonella. Amoeba parasites, flagellates, giardia... After oral use, the drug is rapidly absorbed from the gastrointestinal tract. Plasma drug concentrations are similar to intravenous administration of the same dose. The drug is rapidly and widely distributed into the body, with concentrations close to those in serum, in the lungs, kidneys, liver, skin, bile, cerebrospinal fluid, saliva, semen, and vaginal secretions. The drug crosses the placenta and is excreted in breast milk. The plasma half-life is 8 to 10 hours. It is metabolized mainly in the liver and excreted by the kidneys as metronidazole or its metabolite.

Flagyl medicine 250mg is indicated in the following cases:
Trichomonas vaginalis infection of the urinary tract, genitals in men and women. Giardia lambia and amebiasis. Inflammation of the mouth and tongue. Prophylaxis in cases of infections caused by anaerobic bacteria. Prevention of infection after gastrointestinal surgery and gynecological surgery. Contraindications:
Patients with a history of allergy to metronidazole or excipients contained in the drug. Patients allergic to other drugs of the nitro 5-imidazole group. Do not use for pregnant women in the first 3 months. For women in the second and third trimesters of pregnancy, lactating women should use caution. 3. Dosage of Flagyl 250mg The dose used varies depending on the disease and age. Below is the dose for each specific case:
Amoeba infection: Adults: take 6 Flagyl 250mg tablets per day divided into 3 oral doses. Children: oral dose of 30 to 40 mg/kg/day divided into 3 oral doses. In case of liver abscess infection caused by amoeba, drainage or pus pump is performed in combination with metronidazole treatment. The usual duration of treatment is 7 consecutive days.
Trichomoniasis: Women (urethritis and vaginitis caused by Trichomonas): Take 2 tablets per day divided into two oral doses. The sexual partner must be treated simultaneously, with or without any clinical signs of Trichomonas vaginalis infection, including negative laboratory results. Continuous treatment for 10 days in combination with other measures. Men (Trichomonas urethritis): Take 2 tablets per day in two divided doses for 10 days Giardia infection: Treatment duration is 5 consecutive days. Adults and children over 15 years old: take 0.750g to 1g/day divided into 2 times. Children from 6 to 10 years old: 375mg/day, divided into 2 doses. Children from 10 to 15 years old: take 2 tablets / day, divided into 2 times. Non-specific vaginitis: Take 4 tablets per day in two divided doses for 7 days and must simultaneously treat sexual partners. Anaerobic infections are also susceptible to the antibiotic metronidazole. Adults: take 4 to 6 tablets per day, divided into 2 to 3 times. Children: 20 to 30mg/kg/day. 4. Undesirable effects When using Flagyl 250mg, some unwanted effects may occur as follows:
Gastrointestinal disorders: Causes epigastric pain, nausea, vomiting, diarrhea. Oral mucositis, taste changes, bitter mouth, loss of appetite. Very rarely, pancreatitis can cause pancreatitis, but it's treatable. Change the color of the tongue. Immune system disorders: This is a rare reaction causing angioedema, anaphylaxis. Causes symptoms such as abdominal cramps, shortness of breath, tachycardia, low blood pressure ... need to be treated urgently. Nervous system disorders: Causes neurological diseases such as sensory disturbances, headache, convulsions, dizziness. There have been some reports of encephalopathy (eg, confusion), subacute cerebellar disease that can be resolved with discontinuation of the drug. Aseptic meningitis. Psychiatric disorders: Psychotic symptoms caused by this drug include confusion and hallucinations, depression. Visual disturbances: Transient visual disturbances, optic neuritis. Blood cell effects: Very rare cases of agranulocytosis, decreased neutrophil count and thrombocytopenia. Affects hepatobiliary function: Some cases increase liver enzymes, cholestatic hepatitis and hepatocellular damage, jaundice. Several cases of liver failure requiring liver transplantation have been reported in patients treated with metronidazole in combination with certain other antibiotics. Skin and subcutaneous tissue manifestations: Rash, itching, flushing, urticaria; pustules; Stevens Johnson syndrome.

When using Flagyl 250mg, to ensure safety, users should note the following:
It is necessary to use the drug according to the recommended dose and time. Do not arbitrarily increase the dose, reduce the dose and stop taking the drug when the symptoms of the disease are relieved without the consent of the treating doctor. If dangerous side effects occur, stop the drug and notify or immediately go to the nearest medical facility. If there is a reason the patient must take metronidazole for longer than the recommended duration of treatment. Patients should regularly have blood tests, especially white blood cells. In addition, patients should be monitored for peripheral or central nervous system side effects such as paresthesia, loss of coordination, dizziness, and convulsions. Alcohol should not be consumed during treatment and for at least 24 hours after the end of treatment because of the potential for a disulfiram-like reaction including signs of skin redness, flushing, vomiting and tachycardia. In case of severe active or chronic central or peripheral nervous system disease, this drug should be used with caution because of the risk of aggravation of neurological symptoms. Red-brown urine may appear during treatment, but there are no consequences and will clear up when the drug is stopped. Note drug interactions: Some drugs can interact with Flagyl 250mg, increasing the risk of toxicity, including disulfiram, anticoagulants, lithium, Cyclosporin, busulfan... Note when operating vehicles Due to the risk of confusion, dizziness, hallucinations, convulsions or transient visual disturbances, patients should be advised not to drive or operate machinery if this occurs. these symptoms. Overdose may occur with a single dose of up to 12g: Metronidazole has been reported in cases of suicide or in accidental overdose. Possible symptoms include: vomiting, loss of coordination, mild disorientation, dry mouth, tendency to faint, skin rash, headache, mild depression, decreased sense of taste and sadness vomit. Treatment: There is no specific antidote for this drug. In case of overdose, gastric lavage should be carried out and symptomatic treatment should be performed. Pregnant women: For pregnant women, it is found that the drug crosses the placenta, so it is not recommended to use for pregnant women in the first 3 months. For the following months, use only when absolutely necessary and always weigh the benefits and risks. Lactation: The drug is excreted in breast milk, causing a bitter taste in milk, making it difficult for babies to breastfeed. In addition, it can cause adverse effects on infants and young children. Therefore, if the mother must take medicine, she should stop giving milk to the baby after at least 12 hours after taking each single dose. Above is the necessary information of the drug Flagyl 250mg. Note: This is a group of prescription drugs, so it should be used under the guidance of a doctor, do not arbitrarily use because it can be harmful to the body.