Uses of Lacipil 4mg

Lacipil 4mg drug is made in the form of film-coated tablets with the main ingredient Lacidipine. The drug is effective in the treatment of hypertensive disease as monotherapy or in combination with other antihypertensive drugs.

The composition of the drug in each Lacipil 4mg film-coated tablet contains:
Lacidipine with a strength of 4mg; Other excipients in sufficient quantity 1 tablet. The dosage form of Lacipil 4mg is a film-coated tablet.
Pharmacodynamics of Lacipil 4mg:
Active ingredient Lacidipine has a very strong calcium inhibitory effect, acting on calcium channels in smooth muscle. Lacidipine is a very potent and specific calcium channel antagonist that is highly selective for vascular smooth muscle calcium channels. The main effects of the drug are dilatation of peripheral arterioles, reduction of peripheral vascular resistance and reduction of blood pressure. Lacidipine is a strong calcium channel blocker, it belongs to the dihydropyridine group but has high selectivity, advantages over other active ingredients in the same group. This active ingredient works under the mechanism of dilating the peripheral arterioles thereby lowering the pressure of the peripheral blood and effectively reducing blood pressure. When active ingredient Lacidipine enters the body, it will be absorbed very quickly through the gastrointestinal tract. The concentration of this active substance peaks in plasma after an average of 30 to 120 minutes after dosing. Elimination of the drug takes place mainly through the liver. Most of the residual drug residues are excreted mainly in the faeces, while the remainder is metabolized and excreted in the urine. Pharmacokinetics of Lacipil 4mg:
Absorption: After taking Lacipil 4mg, active ingredient Lacidipine is rapidly absorbed but little from the gastrointestinal tract and mostly metabolized by the liver. Average bioavailability is about 10%. Peak plasma concentrations are reached after about 30 to 150 minutes. Distribution: Lacipil is highly protein bound (more than 95%), including albumin and alpha-1-glycoprotein. Metabolism: Lacipil 4mg has 4 major metabolites, but these metabolites have little pharmacodynamic effects. Lacipil is eliminated mainly by hepatic metabolism. Elimination: Approximately 70% of a therapeutic dose is eliminated as metabolites in the feces and the remainder as metabolites in the urine. The mean half-life of active substance Lacidipine averages between 13 and 19 hours at steady state.

Lacidipine is a calcium channel blocker indicated in the treatment of hypertension alone or in combination with other antihypertensive agents, including beta-blockers, diuretics and inhibitors. ACE.
3. How to use and dose Lacipil 4mg How to use Lacipil 4mg:
You should take Lacipil 4mg at a fixed time every day. It is best to take the medicine in the morning, with or without a meal. If the dose is half a Lacipil 4mg tablet, keep the other half in the blister pack and use it within 48 hours. Dosage of Lacipil 4mg:
Usual starting dose: 2 mg x 1 time/day. Treatment of hypertension should be tailored to the severity of the disease and individual response, and the dose may be increased to 4 mg and 6 mg after an appropriate interval to achieve full pharmacological effects. The doctor can maintain the therapeutic dose of Lacipil 4mg without time limit. Hepatic impairment: No dose adjustment is required in subjects with mild to moderate hepatic impairment. Renal Impairment: No dose adjustment is required in patients with renal impairment because Lacidipine is not excreted by the kidneys. Children: There is no experience with Lacipil 4mg in children. Elderly: No dose adjustment is required. Note when using the drug: The above treatment dose is for reference only. The specific treatment dose depends on the condition and the progression of the disease. For a specific and appropriate dose for your condition, you need to consult your treating doctor or medical professional.
In case of overdose or missed dose:
In case of overdose: The sign of Lacipil 4mg overdose is prolonged peripheral vasodilatation associated with hypotension and tachycardia. Theoretically after taking the drug may occur bradycardia or prolongation of atrioventricular conduction. When you have an overdose of Lacipil 4mg: When you or someone shows an overdose of Lacipil 4mg, you should contact and immediately go to the nearest medical facility for timely intervention and treatment. Physicians may prescribe standard treatments to monitor heart function and provide appropriate supportive measures. In case of missed dose: If you miss a dose of Lacipil 4mg, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. It should be noted that the drug should not be used with double the prescribed dose.

The active ingredient Lacidipine is generally well tolerated. Some people may experience the following undesirable effects:
Nervous system disorders : Headache, dizziness or tremor. Cardiac Disorders: Palpitations, tachycardia, unexplained worsening of angina, syncope, hypotension. Gastrointestinal disorders: Stomach upset, vomiting, gingival hyperplasia. Skin and Subcutaneous Tissue Disorders: Skin rash (including erythema and pruritus), angioedema, urticaria. Renal and urinary disorders: Frequent urination. Systemic disorders and at the site of drug use: Body weakness, edema. Inform your doctor about any unwanted effects you experience while using the drug.

Lacipil 4mg drug interactions include:
Using Lacipil 4mg in combination with other drugs known to lower blood pressure, including those used to treat high blood pressure (eg diuretics, blockers, blockers) beta-blockers or angiotensin-converting enzyme inhibitors) may enhance the antihypertensive effect. However, specific interaction problems have not been identified in studies with commonly used antihypertensive agents (such as beta-blockers and diuretics) or with tolbutamide, digoxin or warfarin. Plasma concentrations of Lacipil 4 mg may be increased when co-administered with Cimetidine. Like other dihydropyridines, Lacipil should not be taken with grapefruit juice. This is because grapefruit juice can change bioavailability. In clinical studies in renal transplant recipients receiving cyclosporin, Lacipil reversed decreased renal plasma flow and glomerular filtration rate. Active ingredient Lacidipine is metabolised by cytochrome CYP3A4, so the concomitant use of strong inducers and inhibitors of CYP3A4 may affect the ability to metabolize and eliminate Lacidipine.

Lacipil 4mg drug is contraindicated in the following cases:
Sensitivity or hypersensitivity to any ingredient of the drug. Patients with severe aortic stenosis. Precautions when using Lacipil 4mg:
Be wary of the possibility that the active ingredient Lacidipine can cause uterine muscle relaxation after delivery. Lacidipine should be used with caution in individuals with a history of abnormalities in SA and AV node activity. As noted for other dihydropyridine calcium channel blockers, Lacipil 4 mg should be used with caution in patients with congenital or acquired QT prolongation. Lacidipine should also be used with caution in individuals receiving concomitant treatment with drugs known to prolong the QT interval such as antiarrhythmics, tricyclic antidepressants, antipsychotics, antibiotics. such as erythromycin and some antihistamines such as terfenadine. As with other calcium channel blockers, Lacipil 4 mg should be used with caution in individuals with poor cardiac reserve. Lacipil 4mg should be used with caution in patients with hepatic impairment because of the potential for increased blood pressure lowering effects. As with other dihydropyridine calcium channel blockers, Lacipil 4 mg should be used with caution in patients with unstable angina. Lacipil 4mg should be used with caution in patients with recent myocardial infarction. After initiation of treatment, if ischemic pain develops or rapidly worsens existing pain, the drug should be discontinued. Lacidipine must be used with caution in patients with heart failure or impaired left ventricular function. Additional precautions:
Pregnancy: There are no data on the safety of Lacipil in pregnant women. Lacipil should only be used for pregnant women when the doctor has weighed the benefits for the mother to outweigh the possible unwanted effects on the fetus or newborn. Also, consideration should be given to the possibility that Lacipil may induce uterine relaxation in women of full-term pregnancy. Lactation: Animal studies have shown that Lacidipine (or its metabolites) may be excreted in human milk. Lacipil 4mg should only be used by a nursing mother when the doctor has weighed and discussed the benefit to the mother outweighing the potential adverse effects on the fetus or newborn. In summary, Lacipil 4mg is used to treat high blood pressure. Patients need to use the drug exactly as prescribed by the doctor to increase the effectiveness of treatment and ensure safety for health.