Coenzyme Q10, octacosanol and cyclodextrin multi-element supermolecule clathrate compound and preparation method thereof

[0053] Oxidized coenzyme Q of the present invention 10 The ternary supramolecular clathrate with octacosanol cyclodextrin is prepared as follows: take 30 parts by weight of β-cyclodextrin, add 150 parts by weight of water and mix, heat to 60°C, and then add 10 parts by weight of oxidation Coenzyme Q 10 and 1 part by weight of octacosanol, stirred into a paste, put into a colloid mill, circulated and ground 15 times, discharged, added water until the solid content reached 12%, and spray-dried to obtain oxidized coenzyme Q 10 Cyclodextrin ternary supramolecular inclusion compound compounded with octacosanol. Determination of coenzyme Q in clathrate by HPLC and gas chromatography respectively 10 and encapsulation efficiency of octacosanol, coenzyme Q 10 The encapsulation rate was 69.2%, and the encapsulation rate of octacosanol was 65.3%.

[0055] Reduced coenzyme Q of the present invention 10 The ternary supramolecular inclusion compound with octacosanol cyclodextrin is prepared as follows: Take 50 parts by weight of β‐cyclodextrin, add 250 parts by weight of water, mix, heat to 65°C, and then add 10 parts by weight Reduced coenzyme Q 10 and 2 parts by weight of octacosanol, stirred into a paste, put into a colloid mill, circulated and ground 20 times, discharged, added water until the solid content reached 13%, and freeze-dried to obtain reduced coenzyme Q 10 Cyclodextrin ternary supramolecular inclusion compound compounded with octacosanol. Determination of coenzyme Q in clathrate by HPLC and gas chromatography respectively 10 and encapsulation efficiency of octacosanol, coenzyme Q 10 The encapsulation rate was 89.1%, the encapsulation rate of octacosanol was 85.3%, and the calculated encapsulation ratio was 1:0.33:6.06.

[0057] Oxidized coenzyme Q of the present invention 10 The preparation method of the ternary supramolecular inclusion complex with octacosanol cyclodextrin is as follows: take 100 parts by weight of β-cyclodextrin, add 400 parts by weight of water and mix, heat to 90°C, and then add 10 parts by weight of oxidized coenzyme Q 10 and 5 parts by weight of a mixture of 50% octacosanol C22 to C36 higher fatty alkanol, stirred into a paste, put into a colloid mill, and circulated for 20 times of grinding, discharging, adding water until the solid content reaches 11%, Carry out spray drying, obtain oxidized coenzyme Q 10 Cyclodextrin ternary supramolecular inclusion compound compounded with octacosanol. Determination of coenzyme Q in clathrate by HPLC and gas chromatography respectively 10 and encapsulation efficiency of octacosanol, coenzyme Q 10 The encapsulation rate was 85.3%, and the encapsulation rate of octacosanol was 81.4%.