CAR-T Preclinical In Vivo Assay
Explore Best-in-class CAR-TCells for Research and Immunotherapy
www.creative-biolabs.com/car-t
Taking advantage of the CellRapeutics™ platform, Creative Biolabs provides customized, standardized, reliable, and high-quality CAR-Tpreclinical in vivo assay services for clients across the world. Our one-stop service covers all aspects from cell biology to animal tests with a special emphasis on the construction of tumor xenograft models. Various robust animal models and assay systems have been used in-house to greatly facilitate CAR-T development and evaluation project with far less time and budget.
Featured CAR-T Preclinical In Vivo Assay Categories
CAR-T Cell TherapyAnimal Models
• CD34+ HSC Hu-NSG Mice Model
• PBMC Hu-NSG Mice Model
• NHPModels
CAR-T Efficacy Test
• In Vivo Imaging, including bioluminescence imaging (BLI) and positron emission tomography (PET)
• Histologic and PathologicAnalysis
• Clinical Observation, including feed consumption, body weight, behavior, and morphology
Toxicity Evaluation of CAR-T
• Clinical Observation
• Cytokine ReleaseAnalysis
• Tumor LysisAnalysis
Strategies to Harness Cytokine Release Syndrome
• Cytokine blockage
• Corticosteroids therapy
• CRS grading and algorithm treatment
• Suicide gene transfer
Viability and Bio-distribution Study of CAR-T
• In Vivo Proliferation, Survival, and Long-Term Persistence of CAR-TCells
• TCell Migration and Distribution
• MemoryTCell Response
• TCell Perseverance
• Efficacy of Next Generation CAR
Quality Control for In Vivo Assays
• GLPand non-GLP in vivo assay for CAR-T/TCR-T cell therapy
• On-target/off-tumorToxicologic EffectAnalysis
• Tumorigenicity Study
• NeurologicToxicity
• Anaphylaxis
• Graft Versus Host Disease
USA
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Tel:
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Email: info@creative-biolabs.com
Web: https://www.creative-biolabs.com/car-t/
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• GLP-compliant CAR-T/TCR-Tpreclinical project design
• IND application related experiment design
• Method validation
• Formal report generation