Isolates from the United States outbreak are hypervirulent.
A) Groups of five animals were each infected with an infectious inoculum of 1.0×105 cells of VGIIa isolates R265, CA1014, or NIH444, VGIIb isolate R272, or VGIIc isolates EJB15 or EJB18. B) Groups of nine or ten animals were each infected with an infectious inoculum of 5.0×104 cells of VGIIa isolates R265, EJB51, CBS7750, or ICB107, VGIIb isolates R272 or EJB53, VGIIc isolates A6MR38, EJB12, EJB14, EJB15, or EJB18, or C. neoformans var. grubii isolate H99. C–D) Representative H&E stained histopathology slides from lung sections of severely morbid sacrificed animals from the VGIIa/major (R265) (C) and VGIIc (EJB18) (D) genotypes (sections from animals in panel B of this Figure).
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