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Evaluation of a photocrosslinkable hydroxyethyl chitosan hydrogel as a potential drug release system for glaucoma surgery

  • Clinical Applications of Biomaterials
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Abstract

Hydroxyethyl chitosan (HECTS) is a critical derivative of chitosan that has been widely used as biomedical materials due to great water-solubility and excellent biocompatibility. Here, photosensitive hydroxyethyl chitosan was synthesized by introducing azide group on NH2 of HECTS (HECTS-AZ), afterwards FTIR and 1H NMR spectra were detected to confirm the formation of HECTS-AZ. The solution of HECTS-AZ can achieve a sol–gel transition through UV irradiation for 30 s. The evaluation of biocompability and biodegradability in vivo was conducted in rats, visual and pathological examinations exhibited the HECTS-AZ has excellent biocompability and degradation time of the hydrogel is more than 14 weeks. Furthermore, HECTS-AZ hydrogel as an ocular drug delivery system loading heparin was prepared to implant under sclera of rabbit after glaucoma filtration surgery (GFS). The experimental results demonstrated the heparin loaded hydrogel can effectively maintain filtration bleb and lowing intraocular pressure (IOP) after GFS for prolonged time. Besides, obvious inflammatory reactions and side effects have not been observed in ocular during the experimental period. In conclusion, the HECTS-AZ hydrogel is a potential drug delivery device for the treatment of glaucoma and other ocular diseases.

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Acknowledgements

This work was supported by Ocean University of China and by a grant from the Key Research & Development Program of Shandong Province (2016GSF115003). And Independent Innovation and Achievement Transformation Program of Shandong Province (2014ZZCX06203).

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Authors and Affiliations

  1. College of Marine Life Sciences, Ocean University of China, Shandong, Qingdao, PR China

    Xuesong Qiao, Xiaoting Peng, Jing Qiao, Zhiwen Jiang, Baoqin Han & Wanshun Liu

  2. Affiliated Hospital of Heze Medical College, Heze, Shandong, PR China

    Chaozhong Yang

Authors
  1. Xuesong Qiao
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  2. Xiaoting Peng
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  3. Jing Qiao
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  4. Zhiwen Jiang
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  5. Baoqin Han
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  6. Chaozhong Yang
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  7. Wanshun Liu
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Correspondence to Baoqin Han.

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Qiao, X., Peng, X., Qiao, J. et al. Evaluation of a photocrosslinkable hydroxyethyl chitosan hydrogel as a potential drug release system for glaucoma surgery. J Mater Sci: Mater Med 28, 149 (2017). https://doi.org/10.1007/s10856-017-5954-z

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  • DOI: https://doi.org/10.1007/s10856-017-5954-z

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