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Fusarium graminearum Genomics and Beyond

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Genomics of Plant-Associated Fungi: Monocot Pathogens

Abstract

The filamentous ascomycete Fusarium graminearum has been studied intensively over decades. The fungus causes disease and produces mycotoxins on cereal crops, such as wheat, barley, and maize, threatening global food safety and human health. There is no effective approach to manage the disease or control mycotoxin production due to our limited understanding of underlying gene mechanisms and the lack of resistant cultivars. As great credit to the genome sequencing and analysis of F. graminearum, significant progress has been achieved in the past decade, covering multiple aspects including secondary metabolism, sexual and asexual development, and virulence. Together with advances in systematics, molecular diagnostics, molecular genetics and pathogenomics, F. graminearum is emerging as a model species to study fungal–plant interactions and filamentous fungal biology. In this chapter, we review current F. graminearum research in the postgenome era, focusing on the impact of genome sequencing, functional genomics, and technology applications. We also present our view on current challenges and future perspectives.

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Acknowledgment

This chapter is dedicated to Dr. H. Corby Kistler, an inspirational mentor and colleague, and an excellent Fusarium biologist who embraces the power of genomics. The authors would like to thank Dr. Jon Hulvey for critical reading of the manuscript and offering constructive suggestions. LG and LJM are grateful for the support of United States Department of Agriculture, National Institute of Food and Agriculture Grant awards MASR-2009-04374, MAS00441. LJM was also supported by United States Department of Agriculture, National Institute of Food and Agriculture Grant awards 2008-35604-18800 and 2008-35600-04691.

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  1. Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA

    Li Guo & Li-Jun Ma

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  1. Li Guo
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Correspondence to Li-Jun Ma .

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  1. Dep Plant Pathology, North Carolina State University Center for Integrated Fungal Res, Raleigh, North Carolina, USA

    Ralph A. Dean

  2. United States Department of Agriculture Nat Inst Food and Agriculture, Washington, Washington, USA

    Ann Lichens-Park

  3. Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, West Bengal, India

    Chittaranjan Kole

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Guo, L., Ma, LJ. (2014). Fusarium graminearum Genomics and Beyond. In: Dean, R., Lichens-Park, A., Kole, C. (eds) Genomics of Plant-Associated Fungi: Monocot Pathogens. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44053-7_4

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