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Serpula lacrymans, the causative agent of dry rot timber decay in buildings, is a Basidiomycete fungus in the Boletales clade. It owes its destructiveness to a uniquely well-developed capacity to colonize by rapid mycelial spread from sites of initial spore infection, coupled with aggressive degradation of wood cellulose. Genomic methods have recently elucidated the evolution and enzymic repertoire of the fungus, suggesting that it has a distinctive mode of brown rot wood decay. Using novel methods to image nutrient translocation, its mycelium has been modeled as a highly responsive resource-supply network. Dry rot is preventable by keeping timber dry. However, in established outbreaks, further mycelial spread can be arrested by inhibitors of translocation.
Journal of Microbiological Methods
Improved molecular methods to characterise Serpula lacrymans and other Basidiomycetes involved in wood decay2011 •
Proceedings of the National Academy of Sciences of the United States of America
Extensive sampling of basidiomycete genomes demonstrates inadequacy of the white-rot/brown-rot paradigm for wood decay fungi2014 •
Basidiomycota (basidiomycetes) make up 32% of the described fungi and include most wood-decaying species, as well as pathogens and mutualistic symbionts. Wood-decaying basidiomycetes have typically been classified as either white rot or brown rot, based on the ability (in white rot only) to degrade lignin along with cellulose and hemicellulose. Prior genomic comparisons suggested that the two decay modes can be distinguished based on the presence or absence of ligninolytic class II peroxidases (PODs), as well as the abundance of enzymes acting directly on crystalline cellulose (reduced in brown rot). To assess the generality of the white-rot/brown-rot classification paradigm, we compared the genomes of 33 basidiomycetes, including four newly sequenced wood decayers, and performed phylogenetically informed principal-components analysis (PCA) of a broad range of gene families encoding plant biomass-degrading enzymes. The newly sequenced Botryobasidium botryosum and Jaapia argillacea g...
The ISME Journal
Niche differentiation and evolution of the wood decay machinery in the invasive fungus Serpula lacrymans2020 •
Ecological niche breadth and the mechanisms facilitating its evolution are fundamental to understanding adaptation to changing environments, persistence of generalist and specialist lineages and the formation of new species. Woody substrates are structurally complex resources utilized by organisms with specialized decay machinery. Wood-decaying fungi represent ideal model systems to study evolution of niche breadth, as they vary greatly in their host range and preferred decay stage of the substrate. In order to dissect the genetic basis for niche specialization in the invasive brown rot fungus Serpula lacrymans, we used phenotyping and integrative analysis of phylogenomic and transcriptomic data to compare this species to wild relatives in the Serpulaceae with a range of specialist to generalist decay strategies. Our results indicate specialist species have rewired regulatory networks active during wood decay towards decreased reliance on enzymatic machinery, and therefore nitrogen-...
The New phytologist
Insight into trade-off between wood decay and parasitism from the genome of a fungal forest pathogen•Parasitism and saprotrophic wood decay are two fungal strategies fundamental for succession and nutrient cycling in forest ecosystems. An opportunity to assess the trade-off between these strategies is provided by the forest pathogen and wood decayer Heterobasidion annosum sensu lato.•We report the annotated genome sequence and transcript profiling, as well as the quantitative trait loci mapping, of one member of the species complex: H. irregulare. Quantitative trait loci critical for pathogenicity, and rich in transposable elements, orphan and secreted genes, were identified.•A wide range of cellulose-degrading enzymes are expressed during wood decay. By contrast, pathogenic interaction between H. irregulare and pine engages fewer carbohydrate-active enzymes, but involves an increase in pectinolytic enzymes, transcription modules for oxidative stress and secondary metabolite production.•Our results show a trade-off in terms of constrained carbohydrate decomposition and membrane transport capacity during interaction with living hosts. Our findings establish that saprotrophic wood decay and necrotrophic parasitism involve two distinct, yet overlapping, processes.Parasitism and saprotrophic wood decay are two fungal strategies fundamental for succession and nutrient cycling in forest ecosystems. An opportunity to assess the trade-off between these strategies is provided by the forest pathogen and wood decayer Heterobasidion annosum sensu lato.We report the annotated genome sequence and transcript profiling, as well as the quantitative trait loci mapping, of one member of the species complex: H. irregulare. Quantitative trait loci critical for pathogenicity, and rich in transposable elements, orphan and secreted genes, were identified.A wide range of cellulose-degrading enzymes are expressed during wood decay. By contrast, pathogenic interaction between H. irregulare and pine engages fewer carbohydrate-active enzymes, but involves an increase in pectinolytic enzymes, transcription modules for oxidative stress and secondary metabolite production.Our results show a trade-off in terms of constrained carbohydrate decomposition and membrane transport capacity during interaction with living hosts. Our findings establish that saprotrophic wood decay and necrotrophic parasitism involve two distinct, yet overlapping, processes.
Frontiers in Microbiology
Using Wood Rot Phenotypes to Illuminate the “Gray” Among Decomposer Fungi2020 •
Microbial Biotechnology
Xenomic networks variability and adaptation traits in wood decaying fungi2013 •
Detlev Blanke & Ulrich Lins (red.), La arto labori kune. Festlibro por Humphrey Tonkin. Rotterdam: Universala Esperanto-Asocio.
Lingvo – rimedo aŭ resurso?2010 •
2007 •
Memórias do Instituto Oswaldo Cruz
Case-control study of factors associated with chronic Chagas heart disease in patients over 50 years of age2007 •
Cahiers d'anthropologie sociale
Introduction. Anthropologie et pragmatique2009 •
2021 •
Biodiversity of Angola
Biodiversity Conservation: History, Protected Areas and HotspotsJournal of Food Processing and Preservation
EFFECTS of GAMMA-IRRADIATION ON THE CONTENTS of THIAMIN, RIBOFLAVIN, AND VITAMIN B-12 IN DAIRY PRODUCTS FOR LOW MICROBIAL DIETS1989 •
BAOJ Pediatrics
Determinants of Complementary Feeding and Nutrition Status of Children 6-23 Months in Vihiga County, Kenya2017 •
Central European Journal of Immunology
Serum levels of interleukin 33 and its receptor ST2 in patients treated with subcutaneous allergen immunotherapy in intermittent allergic rhinitis2019 •
Journal of Applied Sciences
Suitability of Treated Secondary Sewage Effluent for Irrigation of Horticultural Crops in Botswana2005 •
Journal of Molecular Structure
Computational evaluation on the molecular conformation, vibrational spectroscopy, NBO analysis and molecular docking of betaxolol and betaxolol-chlorthalidone cocrystals2020 •
Estudios sobre Educación
Bilingual Education in the United States of America. Case Studies of an Elementary School2011 •
2018 •
2019 •
JURNAL PENDIDIKAN DASAR PERKHASA: Jurnal Penelitian Pendidikan Dasar
ANALISIS PENGARUH PEMBELAJARAN QUANTUM TERHADAP PROSES DAN HASIL BELAJAR SISWA PADA MATA PELAJARAN IPA KELAS VA DI SDN JOGLO 04 PETANG (studi pre-eksperimen)2018 •
2016 •