Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   - SLE, SSc, AIH, JIA
   - dsDNA, chromatin, Scl70 (in some cases)
 • Speckled pattern:
   - SjS, SLE, DM, SSc, PM/SSc OS, MCTD, UCTD
   - Smith, Sm/RNP, Scl-70, SSA-52 (Ro52), SSA-60 (Ro60), SSB (La), RNA polymerase III, Ku
 • Centromere pattern:
   - SSc, PBC/SSc OS
   - CENP-A, CENP-B
 • Nucleolar pattern:
   - SSc, PM/SSc OS, Raynaud phenomenon, SjS, cancer, other SARD
   - Fibrillarin, RNA polymerase III, PM/Scl100, Th/To, Scl-70 (in some cases)
 • Nuclear dots pattern:
   - PBC, DM, other inflammatory conditions
   - Sp-100, PML, NXP-2 (MORC3 or MJ)
Cytoplasmic Patterns: 
 • Reticular/AMA: 
   - PBC, SSc, PBC/SSc OS, PBC/SjS OS
   - AMA
 • Speckled:
   - SLE, SjS, CTD-ILD, IIM, Raynaud phenomenon
   - EJ, Jo-1, OJ, PL-7, PL-12, MDA5, ribosomal P, SRP
 • Discrete dots/GW body-like: 
   - Neurologic conditions, SjS, SLE, RA, PBC, UCTD
   - Anti-GW182, anti-Su/Ago
 • Golgi/polar: 
   - SLE, SjS, RA, OSs, cerebellar ataxia
   - Giantin/macrogolgin, golgin-95/GM130, golgin-160, golgin97, golgin-245
 • Rods/rings: 
   - HCV treated with pegylated interferon-α/ribaviron combination therapy
   - IMPDH2

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