IDvet’s Post

This white paper summarizes a webinar hosted by Nature Research Custom Media and sponsored by Thermo Fisher Scientific in which the speakers discussed using fragment analysis for the multiplexed identification of viruses and bacteria, focusing on applications for artificial joint infections, inflammatory bowel disease, and improving in vitro fertilization success rates. #fragmentanalysis #CE #thermofisheremp

Researchers at Massachusetts General Hospital (MGH) have discovered a protein called NLRP11 that plays a crucial role in the body's immune response to bacterial infections. When certain bacteria are ingested by immune cells, NLRP11 recognizes them through their outer coat, activating an immune defense against the invasion. NLRP11 is present in humans but not in mice, the common laboratory model for human infection, which could help improve mouse models for studying infections and immune-related diseases. The discovery opens new avenues for understanding the immune system's response to bacterial invaders. Read more: https://lnkd.in/dJhDxXQu #medicalscience #immunesystem #infection #biology #lifescience

A group of PRC researchers just published that they have mutated the Cov-2/Covid-19 virus, to make a supposedly 100% lethal virus. Which is much higher than the currect Covid-19 lethality rate. “Abstract SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) can cause 100% mortality in human ACE2-transgenic mice, potentially attributable to late-stage brain infection. This underscores a spillover risk of GX_P2V into humans and provides a unique model for understanding the pathogenic mechanisms of SARS-CoV-2-related viruses.” As I wrote about in The Wall Street Journal last year, Chinese research is generating these types of viruses, including their publicly self-announced military applications of gene editing. https://lnkd.in/gqGGcPDS https://lnkd.in/gqEBRHtV

NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages https://lnkd.in/g2Km3Tfw

Discover the latest innovations in DNA & RNA technologies on April 16th 2024. This inspiring day shows all the latest developments in a fast-changing industry and demonstrates the impact of DNA research on people and plants. The day is filled with interesting lectures, practical solutions and a lot of knowledge. Prof. dr. John Rossen will explore the power of advanced technologies and machine learning in the diagnosis, prevention, and combat of infectious diseases. He will explain how these techniques contribute to infection prevention. And he will discuss how (personalized) molecular diagnostics, which detect the DNA/RNA of pathogens, can lead to faster and more accurate diagnoses. Check the complete program and register via the website: https://hubs.li/Q02lVxR-0 #laboratoriumtechnologie #FHI #Lifescience

Phage genomes integrated within bacterial genomes, or prophages, often carry genes that defend against further phage attacks. These genes typically operate at the cell surface, blocking phages from binding to their host receptor. The recent discovery of prophage-encoded proteins similar to FimU, a Pseudomonas aeruginosa type IV pilus component, has shed light on a fascinating phage defence mechanism. These phage-derived FimU proteins seamlessly integrate into the pilus structure without disrupting its normal function. However, their presence confers significant protection against phage infections that target the pilus tip, where FimU is believed to be situated. The diversity observed in the phage FimU proteins and the phage tail proteins interacting with FimU hints at a complex evolutionary arms race driven by phage-to-phage competition. This dynamic interplay underscores the adaptability of phages and the ingenious strategies bacteria employ to fend off viral threats. The ability of phages to evolve rapidly and develop countermeasures against bacterial defences underscores the continuous battle for survival at the microscopic level. This groundbreaking discovery represents a novel example of anti-phage defence tactics, showcasing how bacteria can repurpose a surface component with a phage-derived protein to bolster their immunity. The intricate molecular ballet between phages and bacteria highlights the perpetual struggle for dominance in the microbial world. The findings open new avenues for research into the intricate mechanisms underlying phage-host interactions and offer a glimpse into the fascinating world of microbial warfare. https://buff.ly/3TY2d10