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A step toward making human oocytes

The generation of immature human oocytes in vitro highlights the challenges of folliculogenesis.

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Figure 1: Production of human oogonia–like cells in vitro by Yamashiro et al.1

References

  1. Yamashiro, C. et al. Science 362, 356–360 (2018).

    Article  CAS  Google Scholar 

  2. Irie, N. et al. Cell 160, 253–268 (2015).

    Article  CAS  Google Scholar 

  3. Sasaki, K. et al. Cell Stem Cell 17, 178–194 (2015).

    Article  CAS  Google Scholar 

  4. Hikabe, O. et al. Nature 539, 299–303 (2016).

    Article  Google Scholar 

  5. Hayashi, K. et al. Science 338, 971–975 (2012).

    Article  CAS  Google Scholar 

  6. Tang, W.W., Kobayashi, T., Irie, N., Dietmann, S. & Surani, M.A. Nat. Rev. Genet. 17, 585–600 (2016).

    Article  CAS  Google Scholar 

  7. Sarma, U.C., Findlay, J.K. & Hutt, K.J. Best Pract. Res. Clin. Obstet. Gynaecol. https://doi.org/10.1016/j.bpobgyn.2018.07.006 (2018).

    Article  Google Scholar 

  8. Williams, C.J. & Erickson, G.F. Morphology and physiology of the ovary. Endotext. http://www.endotext.org/chapter/morphology-and-physiology-of-the-ovary/ (2000).

  9. Prokopuk, L., Western, P.S. & Stringer, J.M. Epigenomics 7, 829–846 (2015).

    Article  CAS  Google Scholar 

  10. Tang, W.W. et al. Cell 161, 1453–1467 (2015).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Patrick S Western.

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The authors declare no competing financial interests.

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Stringer, J., Western, P. A step toward making human oocytes. Nat Biotechnol 37, 24–25 (2019). https://doi.org/10.1038/nbt.4329

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