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Assistant Lecturer
OB/GYN Department
Benha Faculty of Medicine
2019
Ectopic pregnancy is a high-risk condition where in a
fertilized ovum gets implanted outside the uterine
cavity.
This condition poses a significant threat to women
of reproductive age and is a leading cause of
maternaldeathduringthe first trimester.
Introduction
Ectopic pregnancy still contributes significantly to the
cause of maternalmortalityand morbidity.
While there has been about fourfold increase in
incidence over the couple of decades, but the
mortalityhasbeenslasheddownby 80%.
Recognition of high-risk cases , early diagnosis (even
before rupture) with the use of TVS, serum Beta-
hCG and laparoscopy have significantly improved the
managementof ectopicpregnancy.
Incidence
Safety First
Incidence is increasing
( From 1 % to 2.5 % )
Increasingly detected
Detected early
Current Scenario
95 – 98 % of all ectopic are tubal
Common Sites
P I D  Most important factor( 50 % )
Prior Tubal Surgery Infertility,Reversal, Sterilization
Past H/O ectopic 15 % & linearly increasing
Infertility
ART / Ovulation induction
Progesteroneonly contraceptives,Em.Contraceptives
IUCD
Congenitalfactors,Old age, smoking
Risk Factors
No risk factor found in many cases
Course Of Ectopic Pregnancy
 Spontaneous resolution
 Tubal abortion (Ampullary, fimbrial (
Resolution
Pelvic hematocele
Hematosalpinx
 Tubal rupture (Isthmic,interstitial- at 12-16 wks (
Acute
Chronic
Secondary abdominal
Classicaltriad found in only 1/3rd cases
Pain  90 % cases
Amenorrhoea  80 % cases
Bleeding  70 % cases
Symptomsof shockin acute rupture
Faintingattack typical but rare
It can be asymptomaticalso
Clinical Presentation (Symptoms)
Ectopic pregnancy is a great deceiver
Adenexalmass
Adenexaltenderness
Cervical movementstenderness!
Features of acute abdomen
Cullen’ssign !!
(Superficialedema and bruisingin the
subcutaneousfatty tissue aroundthe umbilicus)
Clinical Presentation (Signs)
Different Presentations
 Emergency presentation Suddenly, without
warning a woman is very unwell, collapses and is
taken to hospital in stage of haemoperitoneum
and hemorrhagic shock.
 Subacute presentation The most common
presentation is with a missed period, positive
pregnancy test, some abdominal pain, and
irregular vaginal bleeding
 High Risk Pregnancy Group After previous
ectopic, tubal surgery or assisted conception
(IVF) → detection rate is high → women are
primary observed.
The discriminatory zone is based upon the
correlation between visibility of the gestational sac
andthehCGconcentration.
It is defined as the serum hCG level above which a
gestational sac should be visualized by ultrasound
examinationif an intrauterinepregnancyis present.
In most institutions, this serum hCG level is 1500 or
2000 IU/LwithTVS “
Thelevelishigher[6500 IU/L]withTAS.
Discriminatory Zone
Serum hCG greater than 1500 IU/L without
visualization of intrauterine or extrauterine
pathology may represent a multiple gestation 
repeat the TVS examination and hCG concentration
two dayslater.
An ectopic pregnancy can be diagnosed if the serum
hCG concentration is increasing or plateaued.
Treatment can be instituted.
A falling hCG concentration is most consistent with a
failed pregnancy (eg, arrested pregnancy, blighted
ovum, tubal abortion, spontaneously resolving
ectopicpregnancy).
B-HCG Above The Discriminatory Zone
Pregnancy of unkown location
Management
Expectant Management
Medical Management
 Contraindications
 Precuations
 Single dose Protocol
 Two dose Protocol
 Multiple dose Protocol
Methotrxate therapy in
Ectopic ( ACOG, 2018)
Contraindications
Precuations
Single dose Protocol
Two dose Protocol
Multiple dose Protocol
Surgical Management
Surgical Management
Laparotomy Vs Laparoscopy
Abdominal Ectopic
Ovarian Ectopic
Cervical Ectopic
Heterotopic Ectopic
ACOG 2018 level A
ACOG 2018 level B
ACOG 2018 level C
Ectopic Pregnancy

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Ectopic Pregnancy

  • 2. Ectopic pregnancy is a high-risk condition where in a fertilized ovum gets implanted outside the uterine cavity. This condition poses a significant threat to women of reproductive age and is a leading cause of maternaldeathduringthe first trimester. Introduction
  • 3. Ectopic pregnancy still contributes significantly to the cause of maternalmortalityand morbidity. While there has been about fourfold increase in incidence over the couple of decades, but the mortalityhasbeenslasheddownby 80%. Recognition of high-risk cases , early diagnosis (even before rupture) with the use of TVS, serum Beta- hCG and laparoscopy have significantly improved the managementof ectopicpregnancy. Incidence
  • 5. Incidence is increasing ( From 1 % to 2.5 % ) Increasingly detected Detected early Current Scenario 95 – 98 % of all ectopic are tubal
  • 7. P I D  Most important factor( 50 % ) Prior Tubal Surgery Infertility,Reversal, Sterilization Past H/O ectopic 15 % & linearly increasing Infertility ART / Ovulation induction Progesteroneonly contraceptives,Em.Contraceptives IUCD Congenitalfactors,Old age, smoking Risk Factors No risk factor found in many cases
  • 8. Course Of Ectopic Pregnancy  Spontaneous resolution  Tubal abortion (Ampullary, fimbrial ( Resolution Pelvic hematocele Hematosalpinx  Tubal rupture (Isthmic,interstitial- at 12-16 wks ( Acute Chronic Secondary abdominal
  • 9. Classicaltriad found in only 1/3rd cases Pain  90 % cases Amenorrhoea  80 % cases Bleeding  70 % cases Symptomsof shockin acute rupture Faintingattack typical but rare It can be asymptomaticalso Clinical Presentation (Symptoms) Ectopic pregnancy is a great deceiver
  • 10. Adenexalmass Adenexaltenderness Cervical movementstenderness! Features of acute abdomen Cullen’ssign !! (Superficialedema and bruisingin the subcutaneousfatty tissue aroundthe umbilicus) Clinical Presentation (Signs)
  • 11. Different Presentations  Emergency presentation Suddenly, without warning a woman is very unwell, collapses and is taken to hospital in stage of haemoperitoneum and hemorrhagic shock.  Subacute presentation The most common presentation is with a missed period, positive pregnancy test, some abdominal pain, and irregular vaginal bleeding  High Risk Pregnancy Group After previous ectopic, tubal surgery or assisted conception (IVF) → detection rate is high → women are primary observed.
  • 12. The discriminatory zone is based upon the correlation between visibility of the gestational sac andthehCGconcentration. It is defined as the serum hCG level above which a gestational sac should be visualized by ultrasound examinationif an intrauterinepregnancyis present. In most institutions, this serum hCG level is 1500 or 2000 IU/LwithTVS “ Thelevelishigher[6500 IU/L]withTAS. Discriminatory Zone
  • 13. Serum hCG greater than 1500 IU/L without visualization of intrauterine or extrauterine pathology may represent a multiple gestation  repeat the TVS examination and hCG concentration two dayslater. An ectopic pregnancy can be diagnosed if the serum hCG concentration is increasing or plateaued. Treatment can be instituted. A falling hCG concentration is most consistent with a failed pregnancy (eg, arrested pregnancy, blighted ovum, tubal abortion, spontaneously resolving ectopicpregnancy). B-HCG Above The Discriminatory Zone
  • 18.  Contraindications  Precuations  Single dose Protocol  Two dose Protocol  Multiple dose Protocol Methotrxate therapy in Ectopic ( ACOG, 2018)