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Metagonimiasis
• Metagonimiyazis, çoğunlukla
  Metagonimus yokagawai ama bazen de M. takashii
  veya M. Miyatai bağırsak trematodlarının neden
  olduğu hastalıktır.
Sınıflandırma
• Şube : Platyhelminthes
  Sınıf : Trematodes
  Takım : Digenia
  Aile : Herterophyidae
  Cins : Metagonimus
Morfoloji ve Evrim
• Çok küçük olan bu trematod, ortalama 1.5 mm
  boyunda ve 0.5 mm enindedir. Ön kısmı dar, arkası
  geniş armut şeklinde olan vücudunun
  yüzeyinde, özellikle ağız çekmeni yakınında çok ufacık
  dikenler vardır. Ağız çekmeni ve orta çizginin sağ
  tarafında, yanda karın çekmeni vardır.
• Yumurtaları sarımsı, kahverengi, oval 27x17 µ
  büyüklüktedir. Bunların içinde yumurtlandığında
  gelişmiş, simetrik yapıda bir mirasidyum bulunur.
• Uygun yumuşakçaların vücuduna giren yumurtadan
  mirasidyum çıkar ve önce sporokist, sonra
  redya, yavru redya ve serkarya haline geçer. Tatlı suya
  geçen kuyruklu serkarya yüzerek belirli balıklara
  eriştiği zaman, bunların vücudunda kurtçuğun
  etrafını kist çevirerek metaserkaryaya dönüşür. Böyle
  tatlı su balıklarını çiğ olarak yiyenler infekte
  olurlar, ince barsaklarında erişkin helmint yerleşir.
Klinik Tanı
• Tanı için dışkıda tipik
  yumurtaların görülmesi gerekir.
  Tedaviden sonra dışkıyla çıkan
  helmintlerin incelenmesi tanıda
  kesinlik sağlar.
Tedavi
• Pazitin düşürülmesinde Prazikuantel ve
  Tetrachloroethylene adı verilen maddeler kullanılır.
  Yaygın olarak kullanılan Parazikuanteldir.
• Bu ilaç canlının kaslarına etki ederek, barsağa
  tutunmasını engeller.
Dünya Dağılımı
• Kore ve Japonya başta olmak üzere
  Çin, Tayvan, Balkanlar, İspanya, Endonezya, Filipinler
  ve Rusya gibi ülkelerde oldukça yaygındır.
• Korede 240.000 kişinin bu paraziti taşıdığı tahmin
  edilmektedir. Bunların 120.000’i
  M.yokagawai, 20.000’i M. Takahashii ve 100.000’i M.
  Miyatai’dir.
Referanslar
•   Ahn, Yung-Kyum. Ahn, Yung-Kyum. “Intestinal flukes of genus Metagonimus and their second intermediate hosts in Kangwon-do.” Korean Journal of Parasitology. Cinsi Metagonimus ve quot;Intestinal flukes ve
    Kangwon onların ikinci ara ev sahipliği yapmak.quot; Korece Dergi ve Parazitoloji. Vol. Vol. 31: 331-340. 31: 331-340. 1993. 1993.
•   Ash, Lawrence; Orihel, Thomas. Kül Lawrence; Orihel Thomas. Atlas of Human Parasitology. Atlas İnsan ve Parazitoloji. Fourth Edition. Fourth Edition. American Society of Clinical Pathologists. American Society of
    Clinical pataloğu bir. 1997. 1997. Chai, Jong-Yil et al. Chai, Jong-Yıl vd. “An epidemiological study of metagonimiasis along the upper reaches of the Namham River.” Korean Journal of Parasitology. quot;The Namham
    Nehri üst ulaştığında birlikte metagonimiasis bir epidemiyolojik çalışma. Korece Dergi ve Parazitoloji. Vol. Vol. 31: 99-108. 31: 99-108. 1993. 1993.
•   Chi, Je G. et al. Chi, Je G. et al. “Intestinal Pathology in Human Metagonimiasis with Ultrastructural Observation of Parasites.” Journal of Korean Medical Science. quot;Intestinal Patoloji İnsan Metagonimiasis olarak
    Ultrastructural Gözlem parazitler ile.quot; Journal of Turkish Medical Science. Vol. Vol. 3: 171-177. 3: 171-177. 1998. 1998.
•   Despommier D.; Gwadz R.; Hotez P.; Knirsch C. Parasitic Diseases. Despommier D.; Gwadz R.; Hotez P.; Knirsch C. parazit Hastalıkları. Fifth Edition. Fifth Edition. New York: Apple Trees Productions. New York: Elma
    Ağaçları Productions. 2006. 2006. Doenhoff, MJ, D. Cioli, and J. Utzinger. Doenhoff, MJ, D. Cioli, ve J. Utzinger. “Praziquantel: mechanisms for action, resistance, and new derivatives for schistosomiasis.” Current
    Opinion in Infectious Diseases. quot;Praziquantel: eylem, direnç mekanizmaları ve schistosomiasis için yeni türevleri.quot; Bulaşıcı Hastalıklar Güncel Düşünce. Vol 21:659-667. Cilt 21:659-667. 2008. 2008.
•   FAO/NACA/WHO. FAO / NACA / WHO. “Food Safety Issues Associated with Products from Aquaculture.” WHO Technical Report Series. quot;Gıda Güvenliği Sorunları İlişkili Ürünler Su Ürünleri ile.quot; DSÖ Teknik Rapor
    Serileri. Geneva, 1999. Cenevre, 1999.
•   Han, In-Soo et al. Han, In-Soo ve ark. “An Epidemiologic Study on Clonorchiasis and Metagonimiasis in Riverside Areas in Korea.” Korean Journal of Parasitology. quot;An epidemiologic Çalışması Clonorchiasis ve
    Metagonimiasis üzerinde Kore'de Riverside Alanlarda. Korece Dergi ve Parazitoloji. Vol. Vol. 19: 137-150. 19: 137-150. 1981. 1981.
•   Lee, Jin-Ju, et al. Lee, Jin-sa, et al. “Decrease of Metagonimus yokogawai Endemicity along the Tamjin River Basin.” Korean Journal of Parasitology. Bu Tamjin Nehri Havzası boyunca Metagonimus yokogawai
    Endemicity ve quot;azaltır.quot; Korece Dergi ve Parazitoloji. Vol. Vol. 46: 269-291. 46: 269-291. 2008. 2008.
•   Lee, Gye-Sung et al. Lee, Gye-Sung ve ark. “Epidemiological study of clonorchiasis and metagonimiasis along the Geum-gang in Okcheon-gun, Korea.” Korean Journal of Parasitology. Clonorchiasis ve Geum
    boyunca metagonimiasis ve quot;Epidemiyolojik çalışma-Okcheon olarak çete-silah, Kore. Korece Dergi ve Parazitoloji. Vol. Vol. 40: 9-16. 40: 9-16. 2002. 2002.
•   Lee, Seoung Cheol et al. Lee, Seoung Cheol et al. “Antigenti c protein fractions of Metagonimus yokogawai reacting with patient sera.” Korean Journal of Parasitology. Metagonimus ve quot;Antigenti C proteini kesirli
    hastanın serum ile tepki yokogawai. Korece Dergi ve Parazitoloji. Vol. Vol. 31: 43-48. 31: 43-48. 1993. 1993.
•   Lee, Soo-ung et al. Lee Soo-ung vd. “Sequence comparisons of 28S ribosomal DNA and mitochondrial cytochrome c oxidase subunit I of Metgonimus yokogawai, M. takahashii, and M. miyatai.” Korean Journal of
    Parasitology. 28S ribosomal DNA ve mitokondrial sitokrom C oxidase ve quot;Dizi karşılaştırma Ben Metgonimus yokogawai, M. takahashii ve subunit, ve M. miyatai. Korece Dergi ve Parazitoloji. Vol. Vol. 24: 129-135.
    24: 129-135. 2004. 2004.
•   Lee, Soo-ung et al. Lee Soo-ung vd. “A cytogenetic study on human intestinal trematodes of the genus Metagonimus in Korea.” Korean Journal of Parasitology. quot;Kore ve cinsi Metagonimus insan bağırsak
    trematodes bir sitogenetik çalışma. Korece Dergi ve Parazitoloji. Vol. Vol. 37: 237-241. 37: 237-241. 1999. 1999.
•   Markell, EK; John, DT; Krotoski, WA. Markell, EK, John DT; Krotoski, WA. Markell and Voge's Medical Parasitology. Markell ve Voge Tıbbi Parazitoloji. Ninth Edition. Dokuzuncu Baskı. Philadelphia: WB Saunders
    Company. Philadelphia: WB Saunders Company. 2006. 2006.
•   Mehlhorn, Heinz. Mehlhorn, Heinz. Encyclopedic Reference of Parasitology. Ansiklopedik Referans Parazitoloji ve. Second Edition. Second Edition. Germany: Springer. Almanya: Springer. 2001. 2001.
•   “Metagonimiasis.” Gideon Online. http://web.gideononline.com/web/epidemiology/index.php?gdn_form=ZGlzZWFzZT0xMTQ5MA== quot;Metagonimiasis.quot; Gideon Online.
    Http://web.gideononline.com/web/epidemiology/index.php?gdn_form=ZGlzZWFzZT0xMTQ5MA ==
•   Pawlowski, Zbigniew S. “Intestinal Helminthiases and Human Health: Recent Advances and Future Needs.” Parasitic Disease Programme, WHO. Pawlowski, Zbigniew S. quot;Intestinal Helminthiases ve İnsan Sağlığı:
    Son Gelişmeler ve Gelecek Gerekiyor.quot; Parazit Hastaligi Programı, WHO. 1987. 1987.
Serhat SERTTAŞ
052510006

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Metagonimiasis

  • 2. • Metagonimiyazis, çoğunlukla Metagonimus yokagawai ama bazen de M. takashii veya M. Miyatai bağırsak trematodlarının neden olduğu hastalıktır.
  • 3.
  • 4. Sınıflandırma • Şube : Platyhelminthes Sınıf : Trematodes Takım : Digenia Aile : Herterophyidae Cins : Metagonimus
  • 5. Morfoloji ve Evrim • Çok küçük olan bu trematod, ortalama 1.5 mm boyunda ve 0.5 mm enindedir. Ön kısmı dar, arkası geniş armut şeklinde olan vücudunun yüzeyinde, özellikle ağız çekmeni yakınında çok ufacık dikenler vardır. Ağız çekmeni ve orta çizginin sağ tarafında, yanda karın çekmeni vardır. • Yumurtaları sarımsı, kahverengi, oval 27x17 µ büyüklüktedir. Bunların içinde yumurtlandığında gelişmiş, simetrik yapıda bir mirasidyum bulunur.
  • 6.
  • 7. • Uygun yumuşakçaların vücuduna giren yumurtadan mirasidyum çıkar ve önce sporokist, sonra redya, yavru redya ve serkarya haline geçer. Tatlı suya geçen kuyruklu serkarya yüzerek belirli balıklara eriştiği zaman, bunların vücudunda kurtçuğun etrafını kist çevirerek metaserkaryaya dönüşür. Böyle tatlı su balıklarını çiğ olarak yiyenler infekte olurlar, ince barsaklarında erişkin helmint yerleşir.
  • 8.
  • 9. Klinik Tanı • Tanı için dışkıda tipik yumurtaların görülmesi gerekir. Tedaviden sonra dışkıyla çıkan helmintlerin incelenmesi tanıda kesinlik sağlar.
  • 10. Tedavi • Pazitin düşürülmesinde Prazikuantel ve Tetrachloroethylene adı verilen maddeler kullanılır. Yaygın olarak kullanılan Parazikuanteldir. • Bu ilaç canlının kaslarına etki ederek, barsağa tutunmasını engeller.
  • 11. Dünya Dağılımı • Kore ve Japonya başta olmak üzere Çin, Tayvan, Balkanlar, İspanya, Endonezya, Filipinler ve Rusya gibi ülkelerde oldukça yaygındır. • Korede 240.000 kişinin bu paraziti taşıdığı tahmin edilmektedir. Bunların 120.000’i M.yokagawai, 20.000’i M. Takahashii ve 100.000’i M. Miyatai’dir.
  • 12. Referanslar • Ahn, Yung-Kyum. Ahn, Yung-Kyum. “Intestinal flukes of genus Metagonimus and their second intermediate hosts in Kangwon-do.” Korean Journal of Parasitology. Cinsi Metagonimus ve quot;Intestinal flukes ve Kangwon onların ikinci ara ev sahipliği yapmak.quot; Korece Dergi ve Parazitoloji. Vol. Vol. 31: 331-340. 31: 331-340. 1993. 1993. • Ash, Lawrence; Orihel, Thomas. Kül Lawrence; Orihel Thomas. Atlas of Human Parasitology. Atlas İnsan ve Parazitoloji. Fourth Edition. Fourth Edition. American Society of Clinical Pathologists. American Society of Clinical pataloğu bir. 1997. 1997. Chai, Jong-Yil et al. Chai, Jong-Yıl vd. “An epidemiological study of metagonimiasis along the upper reaches of the Namham River.” Korean Journal of Parasitology. quot;The Namham Nehri üst ulaştığında birlikte metagonimiasis bir epidemiyolojik çalışma. Korece Dergi ve Parazitoloji. Vol. Vol. 31: 99-108. 31: 99-108. 1993. 1993. • Chi, Je G. et al. Chi, Je G. et al. “Intestinal Pathology in Human Metagonimiasis with Ultrastructural Observation of Parasites.” Journal of Korean Medical Science. quot;Intestinal Patoloji İnsan Metagonimiasis olarak Ultrastructural Gözlem parazitler ile.quot; Journal of Turkish Medical Science. Vol. Vol. 3: 171-177. 3: 171-177. 1998. 1998. • Despommier D.; Gwadz R.; Hotez P.; Knirsch C. Parasitic Diseases. Despommier D.; Gwadz R.; Hotez P.; Knirsch C. parazit Hastalıkları. Fifth Edition. Fifth Edition. New York: Apple Trees Productions. New York: Elma Ağaçları Productions. 2006. 2006. Doenhoff, MJ, D. Cioli, and J. Utzinger. Doenhoff, MJ, D. Cioli, ve J. Utzinger. “Praziquantel: mechanisms for action, resistance, and new derivatives for schistosomiasis.” Current Opinion in Infectious Diseases. quot;Praziquantel: eylem, direnç mekanizmaları ve schistosomiasis için yeni türevleri.quot; Bulaşıcı Hastalıklar Güncel Düşünce. Vol 21:659-667. Cilt 21:659-667. 2008. 2008. • FAO/NACA/WHO. FAO / NACA / WHO. “Food Safety Issues Associated with Products from Aquaculture.” WHO Technical Report Series. quot;Gıda Güvenliği Sorunları İlişkili Ürünler Su Ürünleri ile.quot; DSÖ Teknik Rapor Serileri. Geneva, 1999. Cenevre, 1999. • Han, In-Soo et al. Han, In-Soo ve ark. “An Epidemiologic Study on Clonorchiasis and Metagonimiasis in Riverside Areas in Korea.” Korean Journal of Parasitology. quot;An epidemiologic Çalışması Clonorchiasis ve Metagonimiasis üzerinde Kore'de Riverside Alanlarda. Korece Dergi ve Parazitoloji. Vol. Vol. 19: 137-150. 19: 137-150. 1981. 1981. • Lee, Jin-Ju, et al. Lee, Jin-sa, et al. “Decrease of Metagonimus yokogawai Endemicity along the Tamjin River Basin.” Korean Journal of Parasitology. Bu Tamjin Nehri Havzası boyunca Metagonimus yokogawai Endemicity ve quot;azaltır.quot; Korece Dergi ve Parazitoloji. Vol. Vol. 46: 269-291. 46: 269-291. 2008. 2008. • Lee, Gye-Sung et al. 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