Cholemia is a condition caused by the presence of excess bile in the blood. Its symptoms can include somnolence (drowsiness), yellow tinge to skin and whites of eyes, fatigue, nausea and, in extreme cases, coma. It is often an early sign of liver disease.
4. Cholestasis is defined as stagnation, or at least a marked reduction, in bile
secretion and flow. Cholestasis can be due to a functional impairment of the
hepatocytes in the secretion of bile and/or due to an obstruction at any level
of the excretory pathway of bile, from the level of the hepatic parenchymal
cells at the basolateral (sinusoidal) membrane of the hepatocyte to the
ampulla of Vater in the duodenum. Cholestatic jaundice can thus be classified
into intrahepatic or extrahepatic cholestasis, depending upon the level of
obstruction to bile flow. Intrahepatic cholestasis or functional cholestasis can
be due to a disease involving the liver parenchymal cells and/or the
intrahepatic bile ducts. Intrahepatic cholestasis can be further subclassified as
intralobular (disease of liver parenchymal cells and transporter molecules)
and extralobular (disease involving intrahepatic bile ducts) cholestasis.
Extrahepatic cholestasis or obstructive cholestasis is due to excretory block
outside of the liver, along with the extrahepatic bile ducts .
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Cholestasis can occur either in a hepatocellular pattern where there is an impairment
in bile synthesis. Bile is a highly complex, water-soluble medium. Bile formation
included multiple different mechanisms of conjugation with multilevel regulation. The
content of bile is transported in canaliculus via transported protein which creates a
chemical and osmotic gradient through which water enters the canaliculi.
Identification of abnormalities within some of these transporter proteins has led to an
understanding mechanism of certain diseases better such as benign recurrent
intrahepatic cholestasis (F1C1 locus gene) and progressive familial intrahepatic
cholestasis (F1C2 locus gene). Failure to transport this bile salts lead to its
accumulation within the liver. The strong detergent-like effect of the bile salts causes
membrane injury and impairment of membrane function. Another mechanism of
cholestasis is the physical obstruction to bile flow at the level of extrahepatic biliary
ducts. Retained bile similarly causes hepatotoxicity.
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8. • Acholia is the lack or absence of bile secretion.It
can also be referred to as hypocholia. Acholia is
an uncommon trouble of the biliary function in
the liver; bile flow dissipates.
• Cause
• A condition in which little or no bile is secreted or the
flow of bile into the digestive tract is obstructed. The
acholia is a sign of many diseases, such as hepatitis.
Acholia causes the color of feces to fade
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12. If a bile duct becomes permanently blocked, it can
lead to a build-up of bile inside the gallbladder.
This can cause the gallbladder to become infected
and inflamed.The medical term for inflammation of
the gallbladder is acute cholecystitis.
.Symptoms include:
pain in your upper abdomen that travels towards
your shoulder blade (unlike biliary colic, the pain
usually lasts longer than 5 hours)a high
temperature (fever) of 38C or abovea rapid
heartbeat