I am no expert but here is what I have done in the past.
I defoliate, top, and train all through veg to get the plants even for a flowing stretch.
The day before I flip the lights to 12-12 I strip the plant pretty bare, taking every fan leaf with a petiole, and lolipopping the under growth.
Second defoliation is usually done from day 15 to 21 ish
When the plants structure is set, stretch is over, and it has begun to produce a good amount of pistols.
This defolation is done the same as the first, stripped down. Then relax and wait
At this point I take clones from the trim, they tend to grow pretty rapidly with the flowing hormones juicing them
Cheers