Uses of Prome-NIC

Prome-NIC is an antiallergic drug, the drug is made in the form of sugar coated tablets with the main ingredient in each tablet is Promethazine hydrochloride 10mg.
Promethazine is a phenothiazine derivative structurally different from the antipsychotic phenothiazines in the side-chain and without a ring substitution. Scientists believe that this configuration causes Promethazine to reduce dopaminergic effects in the central nervous system (only 1/10 of the effect of clopromazine). Promethazine has two main effects that are antihistamine and strong sedative. However, it can also paradoxically stimulate or inhibit the central nervous system. Central nervous system depression with sedation is common when therapeutic doses of antihistamines are used. In addition, Promethazine also has antiemetic, anti motion sickness and local anesthetic, anticholinergic effects. In particular, this active ingredient also has a mild antitussive effect, showing the ability to inhibit respiration.
Promethazine is an H1-receptor blocker due to contention with histamine for the positions of H1-receptors on effector cells. However, it does not prevent the release of histamine, so it only works to block the reactions caused by histamine. Promethazine has antagonistic effects to varying degrees. This active ingredient is used in pre-anesthesia, before procedures that can cause the release of histamine. In addition, the anticholinergic effect of Promethazine also causes dryness of the nose and oral mucosa. Promethazine is anticholinergic, blocking the response to acetylcholine via the muscarinic receptor. Promethazine's antiemetic, anti-motion sickness and anti-vertigo effects are due to central anticholinergic effects on the vestibule, on the vomiting center, and on the chemoreceptor trigger region of the midbrain. The mild antitussive effect of this active substance may be due to its anticholinergic and CNS depressant properties. Promethazine and other phenothiazines have alpha adrenergic blocking effects, so there is a risk of orthostatic hypotension.

2.1. Indications Prome-NIC is indicated in the following cases:
Used for symptomatic treatment or prevention of hypersensitivity reactions such as urticaria, pruritus, angioedema, rhinitis, conjunctivitis. Used for sedation in both children (except young children) and adults. Prome-NIC is used to reduce anxiety and induce light sleep, making it easier to wake up from sleep. 2.2. Contraindications Prome-NIC is contraindicated in the following cases:
People in a coma or taking MAOIs. Pregnant and lactating women. Newborns and premature babies.

Prome-NIC is to be taken orally. The dose of the drug should be according to the prescription of a specialist. The recommended dose for specific cases is as follows:
Use with allergic conditions: Usually take the drug before going to bed, because of its strong sedative effect. Adults: Use 12.5 mg/time, 4 times/day, before meals and at bedtime, or 25mg at bedtime, if needed. Children: Use dose 0.1 mg/kg, every 6 hours; or 0.5 mg/kg dose at bedtime. To prevent seasickness, motion sickness : Adults: Use dose 25mg/time, 2 times/day. The first dose should be taken at least 30 - 60 minutes before departure. The second dose can be repeated after 8-12 hours, if needed. Children: Use a dose of 0.5 mg / kg / time, this dose can be repeated after 8 - 12 hours, if necessary. In case of nausea and vomiting, use only when vomiting persists or the cause of nausea and vomiting is known. Adults: Use dose 12.5 - 25mg/time; every 4-6 hours, if needed. Children: Use dose 0.25 - 0.5 mg/kg, every 4-6 hours.

During the use of Prome-NIC, you may experience some side effects, including:
Drowsiness Drowsiness Postural hypotension Allergic reactions Constipation Dry mouth. If you experience any unusual symptoms while using Prome-NIC, tell your doctor immediately or go to the nearest medical facility for timely treatment.

Prome-NIC may interact with the following drugs:
Sedatives Antidepressants Antihypertensives MAOsympathomimetic drugs. Prome-NIC is an anti-allergic medicine whose main ingredient is Promethazine hydrochloride 10mg. Medicines are prescribed by doctors to treat many different diseases. Therefore, to ensure effective treatment and avoid side effects, users need to carefully read the instructions and consult a doctor or pharmacist before using.
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